Protein Summary
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
- ENST00000367243
- ENSP00000356212
- ENSG00000146469
- ENST00000367244
- ENSP00000356213
- PHM27
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.92 | ||
biological term | 0.85 | ||
disease | 0.7 | ||
cell type or tissue | 0.66 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4658.26 (req: < 5)
Gene RIFs: 91 (req: <= 3)
Antibodies: 469 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4658.26 (req: >= 5)
Gene RIFs: 91 (req: > 3)
Antibodies: 469 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (237)
PXDN
Novelty: 0.00935722
p_int: 0.923807819
p_ni: 0.076192181
Score: 0.187
Data Source: BioPlex,STRINGDB
PPP2R2D
Family: Enzyme
Novelty: 0.0658328
p_int: 0.889902798
p_ni: 0.110096986
p_wrong: 2.16e-7
Score: 0.158
Data Source: BioPlex,STRINGDB
LRP2
Novelty: 0.00143258
p_int: 0.881799345
p_ni: 0.118200655
Score: 0.205
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (207)
Reactome (7)
KEGG (2)
PathwayCommons (7)
WikiPathways (191)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Glucagon-type ligand receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Glucagon-type ligand receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (3)
Components (3)
Processes (25)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 2 | 2 | 1.2 | 90.7 | ||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 74.5 | |||||
myeloid white cell count | 1 | 1 | 1 | 72.3 | |||||
lymphocyte count | 2 | 1 | 2 | 68 | |||||
leukocyte count | 1 | 1 | 1 | 65.3 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 1.2 | 90.7 | ||||
serum gamma-glutamyl transferase measurement | 1 | 74.5 | |||||
myeloid white cell count | 1 | 72.3 | |||||
lymphocyte count | 2 | 68 | |||||
leukocyte count | 1 | 65.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | vasoactive intestinal peptide | VGNC:3785 | 472164 | |||||
Macaque | vasoactive intestinal peptide | 703566 | ||||||
Mouse | MGI:98933 | 22353 | ||||||
Rat | RGD:621647 | 117064 | ||||||
Dog | vasoactive intestinal peptide | VGNC:54000 | 484038 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | vasoactive intestinal peptide | |||||
Macaque | vasoactive intestinal peptide | |||||
Mouse | ||||||
Rat | ||||||
Dog | vasoactive intestinal peptide | |||||
Publication Statistics
PubMed Score 4658.26
PubMed score by year
PubTator Score 4069.62
PubTator score by year
Related Publications
Text Mined References (138)
GeneRif Annotations (91)
Items per page:
0 of 0
PMID | Year | Title |
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