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Tbio
PTH
Parathyroid hormone

Protein Summary
Description
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282091
  • ENSP00000282091
  • ENSG00000152266
  • ENST00000529816
  • ENSP00000433208

Symbol
  • PTH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.98
gene perturbation
0.92
cell type or tissue
0.89
chemical
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32019.74   (req: < 5)
Gene RIFs: 225   (req: <= 3)
Antibodies: 2028   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32019.74   (req: >= 5)
Gene RIFs: 225   (req: > 3)
Antibodies: 2028   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (45)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (322)
1 – 10 of 322
LRP2
Tbio
Novelty: 0.00143258
p_int: 0.791314937
p_ni: 0.208685063
Score: 0.511
Data Source: BioPlex,STRINGDB
PTHLH
Tbio
Novelty: 0.00050137
Score: 0.995
Data Source: STRINGDB
PTH1R
Tclin
Family: GPCR
Novelty: 0.00413989
Score: 0.994
Data Source: Reactome,STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.992
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.992
Data Source: STRINGDB
PTH2
Tdark
Novelty: 0.0288995
Score: 0.981
Data Source: STRINGDB
PTH2R
Tchem
Family: GPCR
Novelty: 0.03397859
Score: 0.978
Data Source: Reactome,STRINGDB
FGF23
Tclin
Novelty: 0.00047318
Score: 0.97
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.968
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  32019.74

PubMed score by year
PubTator Score  13898.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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