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Tbio
TG
Thyroglobulin

Protein Summary
Description
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.86
protein domain
0.85
disease
0.78
gene perturbation
0.69
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9740.1   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 1645   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9740.1   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 1645   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (142)
1 – 10 of 142
TPO
Tclin
Family:  Enzyme
Novelty:  0.00085969
Score:  0.942
Data Source:  STRINGDB
LRP2
Tbio
Novelty:  0.00143258
Score:  0.922
Data Source:  STRINGDB
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
Score:  0.908
Data Source:  STRINGDB
ASGR1
Tbio
Novelty:  0.00209845
Score:  0.898
Data Source:  STRINGDB
MB
Tbio
Novelty:  0.00008405
Score:  0.871
Data Source:  STRINGDB
NKX2-1
Tbio
Family:  TF
Novelty:  0.00077491
Score:  0.857
Data Source:  STRINGDB
SLC5A5
Tbio
Family:  Transporter
Novelty:  0.00139132
Score:  0.828
Data Source:  STRINGDB
DIO2
Tbio
Family:  Enzyme
Novelty:  0.00173094
Score:  0.817
Data Source:  STRINGDB
PAX8
Tchem
Family:  TF
Novelty:  0.0014232
Score:  0.803
Data Source:  STRINGDB
CALCA
Tbio
Novelty:  0.00010496
Score:  0.8
Data Source:  STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
2
2
71.1
2
2
0
1.2
70.4
autoimmune thyroid disease
1
2
0
1.1
67.5
eosinophil percentage of leukocytes
1
1
1
45.7
mathematical ability
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
2
71.1
0
1.2
70.4
autoimmune thyroid disease
0
1.1
67.5
eosinophil percentage of leukocytes
1
45.7
mathematical ability
1
45.2
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroglobulin
VGNC:14597
464407
Mouse
MGI:98733
21819
Rat
RGD:3848
24826
Dog
thyroglobulin
VGNC:47306
482047
Horse
thyroglobulin
VGNC:24049
100058029
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroglobulin
Mouse
Rat
Dog
thyroglobulin
Horse
thyroglobulin
Publication Statistics
PubMed Score 9740.10
PubMed score by year
PubTator Score 2756.40
PubTator score by year