Protein Summary
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Katacalcin is a potent plasma calcium-lowering peptide. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
- ENST00000331587
- ENSP00000331746
- ENSG00000110680
- ENST00000396372
- ENSP00000379657
- ENST00000469608
- ENSP00000420618
- CALC1
- CT
- KC
- PCT
- CGRP
- CALC1
- CGRP1
- CGRP-I
Most Knowledge About | Knowledge Value
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biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16228.14 (req: < 5)
Gene RIFs: 443 (req: <= 3)
Antibodies: 1657 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16228.14 (req: >= 5)
Gene RIFs: 443 (req: > 3)
Antibodies: 1657 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0