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Tbio
CALCA
Calcitonin

Protein Summary
Description
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Katacalcin is a potent plasma calcium-lowering peptide. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331587
  • ENSP00000331746
  • ENSG00000110680
  • ENST00000396372
  • ENSP00000379657
  • ENST00000469608
  • ENSP00000420618

Symbol
  • CALC1
  • CT
  • KC
  • PCT
  • CGRP
  • CALC1
  • CGRP1
  • CGRP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15123.45   (req: < 5)
Gene RIFs: 345   (req: <= 3)
Antibodies: 1657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15123.45   (req: >= 5)
Gene RIFs: 345   (req: > 3)
Antibodies: 1657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2151253
12310
Rat
RGD:2254
24241
Dog
calcitonin receptor-stimulating peptide 3
100187714
Horse
calcitonin-related polypeptide alpha
100033906
Cow
calcitonin related polypeptide beta
514876
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
calcitonin receptor-stimulating peptide 3
Horse
calcitonin-related polypeptide alpha
Cow
calcitonin related polypeptide beta
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01258-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
Gene Ontology Terms (34)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (282)
1 – 10 of 282
CALCRL
Tclin
Family: GPCR
Novelty: 0.00568602
Score: 0.995
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.992
Data Source: STRINGDB
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.991
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.991
Data Source: STRINGDB
CALCR
Tclin
Family: GPCR
Novelty: 0.00112487
Score: 0.987
Data Source: Reactome,STRINGDB
ADM
Tbio
Novelty: 0.0004958
Score: 0.987
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.987
Data Source: STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.985
Data Source: STRINGDB
RAMP2
Tclin
Novelty: 0.01086538
Score: 0.985
Data Source: STRINGDB
PTHLH
Tbio
Novelty: 0.00050137
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  15123.45

PubMed score by year
PubTator Score  3544.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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