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Tbio
P01258
Calcitonin

Protein Summary
Description
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Katacalcin is a potent plasma calcium-lowering peptide. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331587
  • ENSP00000331746
  • ENSG00000110680
  • ENST00000396372
  • ENSP00000379657
  • ENST00000469608
  • ENSP00000420618

Symbol
  • CALC1
  • CT
  • KC
  • PCT
  • CGRP
  • CALC1
  • CGRP1
  • CGRP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16228.14   (req: < 5)
Gene RIFs: 345   (req: <= 3)
Antibodies: 1657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16228.14   (req: >= 5)
Gene RIFs: 345   (req: > 3)
Antibodies: 1657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (282)
CALCRL
Tclin
Family:  GPCR
Novelty:  0.00568602
Score:  0.995
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.992
Data Source:  STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
Score:  0.991
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.991
Data Source:  STRINGDB
ADM
Tbio
Novelty:  0.0004958
Score:  0.987
Data Source:  STRINGDB
CALCR
Tclin
Family:  GPCR
Novelty:  0.00112487
Score:  0.987
Data Source:  Reactome,STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.987
Data Source:  STRINGDB
IAPP
Tchem
Novelty:  0.0005195
Score:  0.985
Data Source:  STRINGDB
RAMP2
Tclin
Novelty:  0.01086538
Score:  0.985
Data Source:  STRINGDB
PTHLH
Tbio
Novelty:  0.00050137
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
12
15
46
3.6
100
vitamin D measurement
12
15
46
3.6
100
vitamin D deficiency
1
1
2
93
vitamin D deficiency
1
1
2
93
BMI-adjusted hip circumference
1
2
4
56.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
46
3.6
100
vitamin D measurement
46
3.6
100
vitamin D deficiency
2
93
vitamin D deficiency
2
93
BMI-adjusted hip circumference
4
56.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2151253
12310
Rat
RGD:2254
24241
Dog
calcitonin receptor-stimulating peptide 3
100187714
Horse
calcitonin-related polypeptide alpha
100033906
Cow
calcitonin related polypeptide beta
514876
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
calcitonin receptor-stimulating peptide 3
Horse
calcitonin-related polypeptide alpha
Cow
calcitonin related polypeptide beta
Publication Statistics
PubMed Score 16228.14
PubMed score by year
PubTator Score 3544.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title