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Tbio
GH2
Growth hormone variant

Protein Summary
Description
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332800
  • ENSP00000333157
  • ENSG00000136487
  • ENST00000423893
  • ENSP00000409294
  • ENST00000449787
  • ENSP00000410618
  • ENST00000456543
  • ENSP00000394122

Symbol
  • GHL
  • GHV
  • GH-V
  • GHB2
  • hGH-V
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.72
protein domain
0.58
cell line
0.51
pathway
0.49
disease
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1390.3   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1390.3   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth hormone 2
100505396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth hormone 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P01242-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (91)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Reactome
Immune System
Reactome
Prolactin receptor signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System
Prolactin receptor signaling
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (63)
1 – 10 of 63
METAP1
Tchem
Family: Enzyme
Novelty: 0.01816253
p_int: 0.999953556
p_ni: 0.000046444
Score: 0.517
Data Source: BioPlex,STRINGDB
ISCA1
Tbio
Novelty: 0.01288069
p_int: 0.996311453
p_ni: 0.003688535
p_wrong: 1.2e-8
Score: 0.224
Data Source: BioPlex,STRINGDB
PRL
Tbio
Novelty: 0.0000905
Score: 0.984
Data Source: Reactome,STRINGDB
GHR
Tclin
Novelty: 0.00105635
Score: 0.975
Data Source: Reactome,STRINGDB
PRLR
Tbio
Novelty: 0.00161982
Score: 0.946
Data Source: Reactome,STRINGDB
SOCS2
Tbio
Novelty: 0.0044049
Score: 0.939
Data Source: Reactome,STRINGDB
CISH
Tbio
Novelty: 0.00145893
Score: 0.926
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.922
Data Source: Reactome,STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.921
Data Source: Reactome,STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.92
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1390.30

PubMed score by year
PubTator Score  152.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer