Protein Summary
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placenta ...more
- ENST00000323322
- ENSP00000312673
- ENSG00000259384
- ENST00000351388
- ENSP00000343791
- ENST00000458650
- ENSP00000408486
- GH
- GHN
- GH-N
- GHB5
- IGHD2
- hGH-N
- IGHD1A
- IGHD1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
chemical | 0.94 | ||
disease | 0.9 | ||
biological process | 0.88 | ||
phenotype | 0.75 | ||
biological term | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1186.84 (req: < 5)
Gene RIFs: 337 (req: <= 3)
Antibodies: 1244 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1186.84 (req: >= 5)
Gene RIFs: 337 (req: > 3)
Antibodies: 1244 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (128)
Nearest Tclin Targets (17)
Downstream (17)
1 – 5 of 17
Pathways (92)
Reactome (7)
KEGG (4)
PathwayCommons (7)
WikiPathways (74)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Growth hormone receptor signaling | ||||
Reactome | Immune System | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Peptide hormone metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Growth hormone receptor signaling | ||||
Immune System | ||||
Metabolism of proteins | ||||
Peptide hormone metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (5)
Components (4)
Processes (16)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | AgBase | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 7 | 8 | 10 | 97.7 | |||||
IGF-1 measurement | 1 | 2 | 2 | 95.2 | |||||
BMI-adjusted hip circumference | 2 | 8 | 9 | 93.3 | |||||
appendicular lean mass | 2 | 2 | 4 | 91.1 | |||||
hematocrit | 2 | 2 | 2 | 88.5 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 10 | 97.7 | |||||
IGF-1 measurement | 2 | 95.2 | |||||
BMI-adjusted hip circumference | 9 | 93.3 | |||||
appendicular lean mass | 4 | 91.1 | |||||
hematocrit | 2 | 88.5 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 1186.84
PubMed score by year
PubTator Score 20218.03
PubTator score by year
Related Publications
Text Mined References (418)
GeneRif Annotations (337)
Items per page:
0 of 0
PMID | Year | Title |
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