Pharos : Target Details

Tbio

Protein Summary

Description

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placenta ...more

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000323322
ENSP00000312673
ENSG00000259384
ENST00000351388
ENSP00000343791
ENST00000458650
ENSP00000408486

Symbol

GH
GHN
GH-N
GHB5
IGHD2
hGH-N
IGHD1A
IGHD1B

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.94

disease	0.9

biological process	0.88

phenotype	0.75

biological term	0.64

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1186.84 (req: < 5)

View Publications

Gene RIFs: 337 (req: <= 3)

View Gene RIFs

Antibodies: 1244 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1186.84 (req: >= 5)

Gene RIFs: 337 (req: > 3)

Antibodies: 1244 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (128)

Explore Interacting Targets

1 – 10 of 128

See Interactions on String-DB

CSH1

Tbio

Novelty: 0.00100314

p_int: 1

Score: 0.976

Data Source: BioPlex,Reactome,STRINGDB

GHR

Tclin

Novelty: 0.00105635

Score: 0.996