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Tbio
LHB
Lutropin subunit beta

Protein Summary
Description
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221421
  • ENSP00000221421
  • ENSG00000104826
  • ENST00000649238
  • ENSP00000497294

Symbol
  • CGB4
  • HH23
  • LSH-B
  • LSH-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
gene perturbation
0.75
disease
0.71
cell type or tissue
0.67
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.52   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 762   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.52   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 762   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
65
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
luteinizing hormone beta polypeptide
VGNC:2324
468950
Macaque
lutropin subunit beta
100429401
Mouse
MGI:96782
16866
Rat
RGD:3006
25329
Dog
luteinizing hormone beta polypeptide
403959
Species
Name
OMA
EggNOG
Inparanoid
Chimp
luteinizing hormone beta polypeptide
Macaque
lutropin subunit beta
Mouse
Rat
Dog
luteinizing hormone beta polypeptide
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (38)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Asparagine N-linked glycosylation
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Asparagine N-linked glycosylation
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (169)
1 – 10 of 169
CGA
Tbio
Novelty: 0.00394017
Score: 0.981
Data Source: Reactome,STRINGDB
LHCGR
Tclin
Family: GPCR
Novelty: 0.00169974
Score: 0.975
Data Source: Reactome,STRINGDB
GPHA2
Tbio
Novelty: 0.01057969
Score: 0.965
Data Source: STRINGDB
FSHR
Tclin
Family: GPCR
Novelty: 0.00123929
Score: 0.959
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.947
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.935
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.935
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.935
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.935
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  563.52

PubMed score by year
PubTator Score  412.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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