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Tbio
FSHB
Follitropin subunit beta

Protein Summary
Description
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254122
  • ENSP00000254122
  • ENSG00000131808
  • ENST00000417547
  • ENSP00000416606
  • ENST00000533718
  • ENSP00000433424

Symbol
  • HH24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological process
0.86
disease
0.67
tissue
0.66
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.69   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 890   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.69   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 890   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glycoprotein hormones
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glycoprotein hormones
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (197)
1 – 10 of 197
FSHR
Tclin
Family: GPCR
Novelty: 0.00142021
Score: 0.995
Data Source: Reactome,STRINGDB
CGA
Tbio
Novelty: 0.00200677
Score: 0.988
Data Source: Reactome,STRINGDB
TSHR
Tclin
Family: GPCR
Novelty: 0.0008779
Score: 0.965
Data Source: STRINGDB
GHRHR
Tclin
Family: GPCR
Novelty: 0.00767412
Score: 0.955
Data Source: STRINGDB
LHCGR
Tclin
Family: GPCR
Novelty: 0.00288857
Score: 0.954
Data Source: STRINGDB
TSHB
Tbio
Novelty: 0.00212016
Score: 0.952
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.951
Data Source: STRINGDB
GPHA2
Tbio
Novelty: 0.0191488
Score: 0.944
Data Source: STRINGDB
INHA
Tbio
Novelty: 0.00183565
Score: 0.938
Data Source: STRINGDB
INHBB
Tbio
Novelty: 0.02067476
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  148.69

PubMed score by year
PubTator Score  277.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer