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Tbio
CGA
Glycoprotein hormones alpha chain

Protein Summary
Description
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000627148
  • ENSP00000486024
  • ENSG00000135346

Symbol
  • HCG
  • LHA
  • FSHA
  • GPHa
  • TSHA
  • GPHA1
  • CG-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
cell type or tissue
0.84
kinase perturbation
0.76
chemical
0.64
small molecule perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.95   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 1423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.95   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 1423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (206)
TSHB
Tbio
Novelty:  0.00194403
Score:  0.988
Data Source:  Reactome,STRINGDB
FSHB
Tbio
Novelty:  0.00510815
Score:  0.988
Data Source:  Reactome,STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.985
Data Source:  STRINGDB
LHB
Tbio
Novelty:  0.00196754
Score:  0.981
Data Source:  Reactome,STRINGDB
FSHR
Tclin
Family:  GPCR
Novelty:  0.00123929
Score:  0.967
Data Source:  Reactome,STRINGDB
LHCGR
Tclin
Family:  GPCR
Novelty:  0.00169974
Score:  0.96
Data Source:  Reactome,STRINGDB
GHRHR
Tclin
Family:  GPCR
Novelty:  0.00637611
Score:  0.96
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.958
Data Source:  STRINGDB
GHRH
Tbio
Novelty:  0.00058152
Score:  0.951
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (53)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Asparagine N-linked glycosylation
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Asparagine N-linked glycosylation
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1
46
2
3
0
1.3
45.6
neutrophil count
1
1
1
21.5
sum of basophil and neutrophil counts
1
1
1
21.2
neutrophil percentage of granulocytes
1
1
1
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46
0
1.3
45.6
neutrophil count
1
21.5
sum of basophil and neutrophil counts
1
21.2
neutrophil percentage of granulocytes
1
21.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycoprotein hormones, alpha polypeptide
462868
Macaque
glycoprotein hormones, alpha polypeptide
697859
Mouse
MGI:88390
12640
Rat
RGD:620436
116700
Dog
glycoprotein hormones, alpha polypeptide
VGNC:39181
403483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycoprotein hormones, alpha polypeptide
Macaque
glycoprotein hormones, alpha polypeptide
Mouse
Rat
Dog
glycoprotein hormones, alpha polypeptide
Publication Statistics
PubMed Score 260.95
PubMed score by year
PubTator Score 206.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title