Protein Summary
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect. The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
- ENST00000217305
- ENSP00000217305
- ENSG00000101327
- ENST00000539905
- ENSP00000440185
- ENST00000540134
- ENSP00000442259
- ADCA
- PENKB
- SCA23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.84 | ||
biological term | 0.71 | ||
PubMedID | 0.69 | ||
gene perturbation | 0.66 | ||
chemical | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2466.2 (req: < 5)
Gene RIFs: 66 (req: <= 3)
Antibodies: 229 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2466.2 (req: >= 5)
Gene RIFs: 66 (req: > 3)
Antibodies: 229 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (364)
ACAD11
Family: Enzyme
Novelty: 0.22908145
p_int: 0.999707951
p_ni: 0.000292049
Score: 0.167
Data Source: BioPlex,STRINGDB
LCN1
Novelty: 0.00510137
p_int: 0.997820161
p_ni: 0.000155337
p_wrong: 0.002024502
Score: 0.311
Data Source: BioPlex,STRINGDB
TIMM8B
Family: Enzyme
Novelty: 0.02843625
p_int: 0.994811707
p_ni: 0.005188292
p_wrong: 1e-9
Score: 0.54
Data Source: BioPlex,STRINGDB
TIMM13
Family: Enzyme
Novelty: 0.04802297
p_int: 0.986451582
p_ni: 0.013548418
Score: 0.513
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (17)
Reactome (9)
KEGG (4)
PathwayCommons (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G-protein activation | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
G-protein activation | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 5 | 4 | 7 | 98.3 | |||||
platelet crit | 2 | 4 | 5 | 97.8 | |||||
lymphocyte count | 3 | 3 | 3 | 97.4 | |||||
platelet count | 4 | 4 | 4 | 97 | |||||
lymphocyte percentage of leukocytes | 2 | 1 | 2 | 83.4 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 7 | 98.3 | |||||
platelet crit | 5 | 97.8 | |||||
lymphocyte count | 3 | 97.4 | |||||
platelet count | 4 | 97 | |||||
lymphocyte percentage of leukocytes | 2 | 83.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | prodynorphin | VGNC:6231 | 469860 | |||||
Macaque | prodynorphin | 716341 | ||||||
Mouse | MGI:97535 | 18610 | ||||||
Rat | RGD:62054 | 29190 | ||||||
Dog | prodynorphin | VGNC:44398 | 485808 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | prodynorphin | |||||
Macaque | prodynorphin | |||||
Mouse | ||||||
Rat | ||||||
Dog | prodynorphin | |||||
Publication Statistics
PubMed Score 2466.20
PubMed score by year
PubTator Score 552.47
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (66)
Items per page:
0 of 0
PMID | Year | Title |
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