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Tbio
PENK
Proenkephalin-A

Protein Summary
Description
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314922
  • ENSP00000324248
  • ENSG00000181195
  • ENST00000451791
  • ENSP00000400894

Symbol
  • PE
  • PENK-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
PubMedID
0.79
disease perturbation
0.68
transcription factor perturbation
0.68
transcription factor binding site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1292.16   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 366   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1292.16   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
2
4
73.2
self reported educational attainment
1
1
1
60.2
household income
1
2
2
36.5
alcohol use disorder measurement
1
1
0
5.8
26.1
body height
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
73.2
self reported educational attainment
1
60.2
household income
2
36.5
alcohol use disorder measurement
0
5.8
26.1
body height
1
12.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proenkephalin
VGNC:819
464186
Macaque
proenkephalin
696649
Mouse
MGI:104629
18619
Rat
RGD:68946
29237
Dog
proenkephalin
VGNC:54116
100687307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proenkephalin
Macaque
proenkephalin
Mouse
Rat
Dog
proenkephalin
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01210-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Metabolism of proteins
Gene Ontology Terms (43)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (400)
1 – 10 of 400
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
p_int:  0.99989494
p_ni:  0.00010506
Score:  0.189
Data Source:  BioPlex,STRINGDB
ANAPC4
Tbio
Family:  Enzyme
Novelty:  0.28937094
p_int:  0.999804484
p_ni:  0.000195513
p_wrong:  2e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
CDC26
Tbio
Family:  Enzyme
Novelty:  0.07456358
p_int:  0.999783383
p_ni:  0.000186966
p_wrong:  0.000029651
Score:  0.261
Data Source:  BioPlex,STRINGDB
CDC23
Tbio
Novelty:  0.0168525
p_int:  0.998173061
p_ni:  0.001826937
p_wrong:  1e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.997776653
p_ni:  0.002223347
Score:  0.204
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.996952137
p_ni:  0.003047859
p_wrong:  4e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
Score:  0.992
Data Source:  STRINGDB
OPRK1
Tclin
Family:  GPCR
Novelty:  0.00171044
Score:  0.979
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.976
Data Source:  STRINGDB
OPRD1
Tclin
Family:  GPCR
Novelty:  0.00757692
Score:  0.976
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1292.16

PubMed score by year
PubTator Score  327.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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