Protein Summary
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
- ENST00000314922
- ENSP00000324248
- ENSG00000181195
- ENST00000451791
- ENSP00000400894
- PE
- PENK-A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.92 | ||
PubMedID | 0.79 | ||
disease perturbation | 0.68 | ||
transcription factor perturbation | 0.68 | ||
transcription factor binding site profile | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1292.16 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 366 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1292.16 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 366 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (400)
ANAPC1
Family: Enzyme
Novelty: 0.0521845
p_int: 0.99989494
p_ni: 0.00010506
Score: 0.189
Data Source: BioPlex,STRINGDB
ANAPC4
Family: Enzyme
Novelty: 0.28937094
p_int: 0.999804484
p_ni: 0.000195513
p_wrong: 2e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
CDC26
Family: Enzyme
Novelty: 0.07456358
p_int: 0.999783383
p_ni: 0.000186966
p_wrong: 0.000029651
Score: 0.261
Data Source: BioPlex,STRINGDB
CDC23
Novelty: 0.0168525
p_int: 0.998173061
p_ni: 0.001826937
p_wrong: 1e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
ANAPC5
Family: Enzyme
Novelty: 0.02102572
p_int: 0.997776653
p_ni: 0.002223347
Score: 0.204
Data Source: BioPlex,STRINGDB
CDC27
Novelty: 0.00589846
p_int: 0.996952137
p_ni: 0.003047859
p_wrong: 4e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (15)
Reactome (11)
KEGG (1)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (2)
Components (11)
Processes (30)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 2 | 4 | 73.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 60.2 | |||||
household income | 1 | 2 | 2 | 36.5 | |||||
alcohol use disorder measurement | 1 | 1 | 0 | 5.8 | 26.1 | ||||
body height | 1 | 1 | 1 | 12.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 4 | 73.2 | |||||
self reported educational attainment | 1 | 60.2 | |||||
household income | 2 | 36.5 | |||||
alcohol use disorder measurement | 0 | 5.8 | 26.1 | ||||
body height | 1 | 12.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | proenkephalin | VGNC:819 | 464186 | |||||
Macaque | proenkephalin | 696649 | ||||||
Mouse | MGI:104629 | 18619 | ||||||
Rat | RGD:68946 | 29237 | ||||||
Dog | proenkephalin | VGNC:54116 | 100687307 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | proenkephalin | |||||
Macaque | proenkephalin | |||||
Mouse | ||||||
Rat | ||||||
Dog | proenkephalin | |||||
Publication Statistics
PubMed Score 1292.16
PubMed score by year
PubTator Score 327.83
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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