Protein Summary
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
- ENST00000314922
- ENSP00000324248
- ENSG00000181195
- ENST00000451791
- ENSP00000400894
- PE
- PENK-A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.92 | ||
PubMedID | 0.79 | ||
disease perturbation | 0.68 | ||
transcription factor perturbation | 0.68 | ||
transcription factor binding site profile | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1320.41 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 366 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1320.41 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 366 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (400)
ANAPC1
Family: Enzyme
Novelty: 0.0521845
p_int: 0.99989494
p_ni: 0.00010506
Score: 0.189
Data Source: BioPlex,STRINGDB
ANAPC4
Family: Enzyme
Novelty: 0.28937094
p_int: 0.999804484
p_ni: 0.000195513
p_wrong: 2e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
CDC26
Family: Enzyme
Novelty: 0.07456358
p_int: 0.999783383
p_ni: 0.000186966
p_wrong: 0.000029651
Score: 0.261
Data Source: BioPlex,STRINGDB
CDC23
Novelty: 0.0168525
p_int: 0.998173061
p_ni: 0.001826937
p_wrong: 1e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
ANAPC5
Family: Enzyme
Novelty: 0.02102572
p_int: 0.997776653
p_ni: 0.002223347
Score: 0.204
Data Source: BioPlex,STRINGDB
CDC27
Novelty: 0.00589846
p_int: 0.996952137
p_ni: 0.003047859
p_wrong: 4e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (15)
Reactome (11)
KEGG (1)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (2)
Components (11)
Processes (30)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
educational attainment | 1 | 2 | 2 | 78.1 | |||||
blood protein measurement | 1 | 1 | 1 | 77.9 | |||||
BMI-adjusted hip circumference | 2 | 2 | 4 | 63.6 | |||||
self reported educational attainment | 1 | 1 | 1 | 50 | |||||
alcohol use disorder measurement | 1 | 1 | 0 | 5.8 | 43.1 | ||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
educational attainment | 2 | 78.1 | |||||
blood protein measurement | 1 | 77.9 | |||||
BMI-adjusted hip circumference | 4 | 63.6 | |||||
self reported educational attainment | 1 | 50 | |||||
alcohol use disorder measurement | 0 | 5.8 | 43.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | proenkephalin | VGNC:819 | 464186 | |||||
Macaque | proenkephalin | 696649 | ||||||
Mouse | MGI:104629 | 18619 | ||||||
Rat | RGD:68946 | 29237 | ||||||
Dog | proenkephalin | VGNC:54116 | 100687307 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | proenkephalin | |||||
Macaque | proenkephalin | |||||
Mouse | ||||||
Rat | ||||||
Dog | proenkephalin | |||||
Publication Statistics
PubMed Score 1320.41
PubMed score by year
PubTator Score 327.83
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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