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Tbio
POMC
Pro-opiomelanocortin

Protein Summary
Description
Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate. This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264708
  • ENSP00000264708
  • ENSG00000115138
  • ENST00000380794
  • ENSP00000370171
  • ENST00000395826
  • ENSP00000379170
  • ENST00000405623
  • ENSP00000384092

Symbol
  • LPH
  • MSH
  • NPP
  • POC
  • ACTH
  • CLIP
  • OBAIRH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
disease
0.75
biological process
0.74
cellular component
0.7
biological term
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37026.55   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 2232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37026.55   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 2232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (66)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Biological oxidations
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Biological oxidations
Class A/1 (Rhodopsin-like receptors)
Cytochrome P450 - arranged by substrate type
Cytokine Signaling in Immune system
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (570)
1 – 10 of 570
TSPAN11
Tdark
Novelty: 0.6
p_int: 0.999999849
p_ni: 1.45e-7
p_wrong: 6e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
TTL
Tchem
Family: Enzyme
Novelty: 0.05571031
p_int: 0.999999571
p_ni: 3.95e-7
p_wrong: 3.4e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
E2F4
Tbio
Family: TF
Novelty: 0.00409946
p_int: 0.999997002
p_ni: 0.000002953
p_wrong: 4.5e-8
Score: 0.451
Data Source: BioPlex,STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.05991158
p_int: 0.944304582
p_ni: 0.055695418
Score: 0.183
Data Source: BioPlex,STRINGDB
KLHL15
Tbio
Novelty: 0.68181818
p_int: 0.928369608
p_ni: 0.071630392
Score: 0.183
Data Source: BioPlex,STRINGDB
AMD1
Tchem
Family: Enzyme
Novelty: 0.00107659
p_int: 0.875258509
p_ni: 0.124741491
Score: 0.212
Data Source: BioPlex,STRINGDB
CRH
Tbio
Novelty: 0.00017805
Score: 0.997
Data Source: STRINGDB
MC2R
Tclin
Family: GPCR
Novelty: 0.00439257
Score: 0.997
Data Source: Reactome,STRINGDB
MC4R
Tclin
Family: GPCR
Novelty: 0.00104053
Score: 0.996
Data Source: Reactome,STRINGDB
NPY
Tbio
Novelty: 0.00014761
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  37026.55

PubMed score by year
PubTator Score  12246.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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