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Tbio
AVP
Vasopressin-neurophysin 2-copeptin

Protein Summary
Description
Neurophysin 2 specifically binds vasopressin. Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156). This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380293
  • ENSP00000369647
  • ENSG00000101200

Symbol
  • ARVP
  • VP
  • VP
  • ADH
  • ARVP
  • AVRP
  • AVP-NPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.93
molecular function
0.91
chemical
0.84
cellular component
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6247.73   (req: < 5)
Gene RIFs: 198   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6247.73   (req: >= 5)
Gene RIFs: 198   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
64.9
household income
2
3
4
55.1
reticulocyte count
1
1
1
50.6
serum gamma-glutamyl transferase measurement
1
1
1
31.4
body mass index
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
64.9
household income
4
55.1
reticulocyte count
1
50.6
serum gamma-glutamyl transferase measurement
1
31.4
body mass index
1
30.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginine vasopressin
VGNC:6048
746870
Mouse
MGI:88121
11998
Rat
RGD:2184
24221
Dog
arginine vasopressin
VGNC:38317
403579
Cow
arginine vasopressin
VGNC:26356
280728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginine vasopressin
Mouse
Rat
Dog
arginine vasopressin
Cow
arginine vasopressin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P01185-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (40)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Circadian Clock
Reactome
Class A/1 (Rhodopsin-like receptors)
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Cargo recognition for clathrin-mediated endocytosis
Circadian Clock
Class A/1 (Rhodopsin-like receptors)
Gene Ontology Terms (49)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (502)
1 – 10 of 502
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.999975596
p_ni:  0.000024401
p_wrong:  3e-9
Data Source:  BioPlex
NIF3L1
Tbio
Novelty:  0.15581813
p_int:  0.999902722
p_ni:  0.000097277
Data Source:  BioPlex
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
p_int:  0.99977256
p_ni:  0.000227369
p_wrong:  7.1e-8
Score:  0.197
Data Source:  BioPlex,STRINGDB
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.998545918
p_ni:  0.00145338
p_wrong:  7.02e-7
Data Source:  BioPlex
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.997083423
p_ni:  0.002916574
p_wrong:  3e-9
Data Source:  BioPlex
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.993466979
p_ni:  0.006533021
Data Source:  BioPlex
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
p_int:  0.991530233
p_ni:  0.008415469
p_wrong:  0.000054297
Score:  0.181
Data Source:  BioPlex,STRINGDB
BDH2
Tbio
Family:  Enzyme
Novelty:  0.04118875
p_int:  0.989167856
p_ni:  0.010832144
Score:  0.19
Data Source:  BioPlex,STRINGDB
GALNT18
Tbio
Family:  Enzyme
Novelty:  0.15496205
p_int:  0.953976719
p_ni:  0.027464105
p_wrong:  0.018559175
Data Source:  BioPlex
B4GALT6
Tbio
Family:  Enzyme
Novelty:  0.08523889
p_int:  0.947821673
p_ni:  0.00101924
p_wrong:  0.051159087
Score:  0.188
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6247.73

PubMed score by year
PubTator Score  8866.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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