Tchem NPPA Natriuretic peptides A

Protein Summary

Description

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P01160
• Q13766
• Q5JZE1

Gene Name

• NPPA

Ensembl ID

• ENST00000376480
• ENSP00000365663
• ENSG00000175206

Symbol

• ANP
• PND
• ANF
• ANP
• CDD
• CDP
• PND
• ATFB6
• ATRST2
• CDD-ANF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
chemical	0.95
disease	0.81
cell type or tissue	0.7
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2565.43   (req: < 5)

Gene RIFs: 187   (req: <= 3)

Antibodies: 667   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2565.43   (req: >= 5)

Gene RIFs: 187   (req: > 3)

Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (11)

Explore Active Ligands

1 – 10 of 11

Sampatrilat

NPPATchem

pKi : 6.76

CHEMBL1778532

NPPATchem

pIC50 : 9.52

CHEMBL1778534

NPPATchem

pIC50 : 9.52

CHEMBL1778530

NPPATchem

pIC50 : 9.22

CHEMBL1778536

NPPATchem

pIC50 : 8.72

CHEMBL1778531

NPPATchem

pIC50 : 8.32

CHEMBL1778533

NPPATchem

pIC50 : 8.3

CHEMBL1778529

NPPATchem

pIC50 : 8.15

CHEMBL1778528

NPPATchem

pIC50 : 7.7

CHEMBL1778527

NPPATchem

pIC50 : 7.66

Protein-Protein Interactions (151)

Explore Interacting Targets

1 – 10 of 151

• See Interactions on String-DB

PM20D1

Tdark

Family:  Enzyme

Novelty:  0.07205788

p_int:  0.99999829

p_ni:  2.5e-8

p_wrong:  0.000001686

Score:  0.187

Data Source:  BioPlex,STRINGDB

A2ML1

Tbio

Novelty:  0.05923067

p_int:  0.99999149

p_ni:  0.000008196

p_wrong:  3.14e-7

Data Source:  BioPlex

NUDT8

Tdark

Novelty:  0.76306116

p_int:  0.999898264

p_ni:  0.000101672

p_wrong:  6.4e-8

Score:  0.518

Data Source:  BioPlex,STRINGDB

LCN2

Tbio

Family:  Enzyme

Novelty:  0.00034678

p_int:  0.999838423

p_ni:  0.00016157

p_wrong:  8e-9

Score:  0.174

Data Source:  BioPlex,STRINGDB

OBSCN

Tbio

Family:  Kinase

Novelty:  0.01173699

p_int:  0.999776683

p_ni:  0.000208535

p_wrong:  0.000014782

Score:  0.299

Data Source:  BioPlex,STRINGDB

GDPD3

Tbio

Family:  Enzyme

Novelty:  0.18121762

p_int:  0.999385702

p_ni:  0.000455044

p_wrong:  0.000159254

Score:  0.179

Data Source:  BioPlex,STRINGDB

SMYD2

Tchem

Family:  Epigenetic

Novelty:  0.0192516

p_int:  0.999315304

p_ni:  0.000658397

p_wrong:  0.000026299

Score:  0.16

Data Source:  BioPlex,STRINGDB

NDUFAF7

Tbio

Family:  Enzyme

Novelty:  0.24691414

p_int:  0.999305582

p_ni:  0.000694418

Data Source:  BioPlex

SDR9C7

Tbio

Family:  Enzyme

Novelty:  0.01618496

p_int:  0.997998377

p_ni:  0.002000587

p_wrong:  0.000001036

Data Source:  BioPlex

NDUFAF5

Tbio

Family:  Enzyme

Novelty:  0.13483499

p_int:  0.995100116

p_ni:  0.00489985

p_wrong:  3.4e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (41)

Reactome (9)

KEGG (10)

PathwayCommons (7)

WikiPathways (15)

Amyloid fiber formation (R-HSA-977225)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Amyloid fiber formation	79 targets	R-HSA-977225
Cardiac conduction	137 targets	R-HSA-5576891
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (40)

Functions (4)

Components (7)

Processes (29)

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1 – 4 of 4

GO Term	Evidence	Assigned by
signaling receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
hormone receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
neuropeptide hormone activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
neuropeptide receptor binding	Inferred from Mutant Phenotype (IMP)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (42)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
homocysteine measurement	EFO_0004578	4	3	6		99
NT-proBNP measurement	EFO_0004745	2	3	3		98.6
diastolic blood pressure	EFO_0006336	4	3	4		97
BNP measurement	EFO_0006920	2	2	2		96.1
blood protein measurement	EFO_0007937	3	4	4		94.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
homocysteine measurement	EFO_0004578	6		99
NT-proBNP measurement	EFO_0004745	3		98.6
diastolic blood pressure	EFO_0006336	4		97
BNP measurement	EFO_0006920	2		96.1
blood protein measurement	EFO_0007937	4		94.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Atrial fibrillation
Cardiomyopathy
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Hormone
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at menopause
Agents acting on the renin-angiotensin system use measurement
Beta blocking agent use measurement
birth weight
blood pressure
blood protein measurement
BMI-adjusted hip circumference
BNP measurement
Calcium channel blocker use measurement
cardiovascular disease biomarker measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
muscle phenotype
nervous system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	natriuretic peptide A	VGNC:1417	736416
Macaque	natriuretic peptide A		714994
Mouse	natriuretic peptide type A	MGI:97367	230899
Rat	natriuretic peptide A	RGD:3193	24602
Dog	natriuretic peptide A	VGNC:43925	608289

Species	Name	OMA	EggNOG	Inparanoid
Chimp	natriuretic peptide A
Macaque	natriuretic peptide A
Mouse	natriuretic peptide type A
Rat	natriuretic peptide A
Dog	natriuretic peptide A

Publication Statistics

PubMed Score 2565.43

PubMed score by year

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PubTator Score 2017.39

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Related Publications

Text Mined References (257)

GeneRif Annotations (187)

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PMID	Year	Title