Tchem NPPA Natriuretic peptides A

Protein Summary

Description

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P01160
• Q13766
• Q5JZE1

Gene Name

• NPPA

Ensembl ID

• ENST00000376480
• ENSP00000365663
• ENSG00000175206

Symbol

• ANP
• PND
• ANF
• ANP
• CDD
• CDP
• PND
• ATFB6
• ATRST2
• CDD-ANF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
chemical	0.95
disease	0.81
cell type or tissue	0.7
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2565.43   (req: < 5)

Gene RIFs: 219   (req: <= 3)

Antibodies: 667   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2565.43   (req: >= 5)

Gene RIFs: 219   (req: > 3)

Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0