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Tchem
NPPA
Natriuretic peptides A

Protein Summary
Description
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376480
  • ENSP00000365663
  • ENSG00000175206

Symbol
  • ANP
  • PND
  • ANF
  • ANP
  • CDD
  • CDP
  • PND
  • ATFB6
  • ATRST2
  • CDD-ANF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
chemical
0.95
disease
0.81
cell type or tissue
0.7
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2123.71   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 667   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2123.71   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BNP measurement
1
1
1
48.7
1
1
0
1.2
38.9
blood protein measurement
1
1
1
18.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BNP measurement
1
48.7
0
1.2
38.9
blood protein measurement
1
18.5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (41)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Cardiac conduction
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Cardiac conduction
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Protein-Protein Interactions (151)
1 – 10 of 151
PM20D1
Tdark
Family: Enzyme
Novelty: 0.07205788
p_int: 0.99999829
p_ni: 2.5e-8
p_wrong: 0.000001686
Score: 0.187
Data Source: BioPlex,STRINGDB
A2ML1
Tbio
Novelty: 0.05923067
p_int: 0.99999149
p_ni: 0.000008196
p_wrong: 3.14e-7
Data Source: BioPlex
NUDT8
Tdark
Novelty: 0.76306116
p_int: 0.999898264
p_ni: 0.000101672
p_wrong: 6.4e-8
Score: 0.518
Data Source: BioPlex,STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
p_int: 0.999838423
p_ni: 0.00016157
p_wrong: 8e-9
Score: 0.174
Data Source: BioPlex,STRINGDB
OBSCN
Tbio
Family: Kinase
Novelty: 0.01173699
p_int: 0.999776683
p_ni: 0.000208535
p_wrong: 0.000014782
Score: 0.299
Data Source: BioPlex,STRINGDB
GDPD3
Tbio
Family: Enzyme
Novelty: 0.18121762
p_int: 0.999385702
p_ni: 0.000455044
p_wrong: 0.000159254
Score: 0.179
Data Source: BioPlex,STRINGDB
SMYD2
Tchem
Family: Epigenetic
Novelty: 0.0192516
p_int: 0.999315304
p_ni: 0.000658397
p_wrong: 0.000026299
Score: 0.16
Data Source: BioPlex,STRINGDB
NDUFAF7
Tbio
Family: Enzyme
Novelty: 0.24691414
p_int: 0.999305582
p_ni: 0.000694418
Data Source: BioPlex
SDR9C7
Tbio
Family: Enzyme
Novelty: 0.01618496
p_int: 0.997998377
p_ni: 0.002000587
p_wrong: 0.000001036
Data Source: BioPlex
NDUFAF5
Tbio
Family: Enzyme
Novelty: 0.13483499
p_int: 0.995100116
p_ni: 0.00489985
p_wrong: 3.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  2123.71

PubMed score by year
PubTator Score  2017.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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