Tbio GNRH1 Progonadoliberin-1

Protein Summary

Description

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P01148
• A0AVP0

Gene Name

• GNRH1

Ensembl ID

• ENST00000276414
• ENSP00000276414
• ENSG00000147437
• ENST00000421054
• ENSP00000391280

Symbol

• GNRH
• GRH
• LHRH
• GRH
• GNRH
• LHRH
• LNRH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.83
disease	0.73
chemical	0.71
tissue	0.65
tissue sample	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5630.19   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 441   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5630.19   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0