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Tbio
GNRH1
Progonadoliberin-1

Protein Summary
Description
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276414
  • ENSP00000276414
  • ENSG00000147437
  • ENST00000421054
  • ENSP00000391280

Symbol
  • GNRH
  • GRH
  • LHRH
  • GRH
  • GNRH
  • LHRH
  • LNRH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
disease
0.73
chemical
0.71
tissue
0.65
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4617.29   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4617.29   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
46.4
reticulocyte measurement
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
46.4
reticulocyte measurement
1
25.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Protein-Protein Interactions (334)
1 – 10 of 334
MTX1
Tbio
Novelty: 0.02350764
p_int: 0.982340572
p_ni: 0.01765534
p_wrong: 0.000004088
Score: 0.227
Data Source: BioPlex,STRINGDB
TRIM68
Tbio
Family: Enzyme
Novelty: 0.11729189
p_int: 0.930346203
p_ni: 0.069653797
Score: 0.179
Data Source: BioPlex,STRINGDB
MALSU1
Tbio
Novelty: 0.38026342
p_int: 0.880604756
p_ni: 0.119395244
Score: 0.183
Data Source: BioPlex,STRINGDB
EMC8
Tdark
Novelty: 0.2452967
p_int: 0.83308951
p_ni: 0.166899577
p_wrong: 0.000010914
Score: 0.243
Data Source: BioPlex,STRINGDB
EMC3
Tbio
Novelty: 0.01113829
p_int: 0.824698316
p_ni: 0.175301684
Score: 0.651
Data Source: BioPlex,STRINGDB
EMC4
Tbio
Novelty: 0.12174476
p_int: 0.776634289
p_ni: 0.033944112
p_wrong: 0.189421599
Score: 0.798
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.7648179
p_ni: 0.2351821
Score: 0.157
Data Source: BioPlex,STRINGDB
GNRHR
Tclin
Family: GPCR
Novelty: 0.00203671
Score: 0.997
Data Source: Reactome,STRINGDB
KISS1
Tbio
Novelty: 0.00096537
Score: 0.995
Data Source: STRINGDB
KISS1R
Tchem
Family: GPCR
Novelty: 0.0026282
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  4617.29

PubMed score by year
PubTator Score  9799.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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