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Tbio
GNRH1
Progonadoliberin-1

Protein Summary
Description
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276414
  • ENSP00000276414
  • ENSG00000147437
  • ENST00000421054
  • ENSP00000391280

Symbol
  • GNRH
  • GRH
  • LHRH
  • GRH
  • GNRH
  • LHRH
  • LNRH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
disease
0.73
chemical
0.71
tissue
0.65
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5630.19   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5630.19   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (334)
MTX1
Tbio
Novelty:  0.02350764
p_int:  0.982340572
p_ni:  0.01765534
p_wrong:  0.000004088
Score:  0.227
Data Source:  BioPlex,STRINGDB
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.930346203
p_ni:  0.069653797
Score:  0.179
Data Source:  BioPlex,STRINGDB
MALSU1
Tbio
Novelty:  0.38026342
p_int:  0.880604756
p_ni:  0.119395244
Score:  0.183
Data Source:  BioPlex,STRINGDB
EMC8
Tbio
Novelty:  0.2452967
p_int:  0.83308951
p_ni:  0.166899577
p_wrong:  0.000010914
Score:  0.243
Data Source:  BioPlex,STRINGDB
EMC3
Tbio
Novelty:  0.01113829
p_int:  0.824698316
p_ni:  0.175301684
Score:  0.651
Data Source:  BioPlex,STRINGDB
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.776634289
p_ni:  0.033944112
p_wrong:  0.189421599
Score:  0.798
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.7648179
p_ni:  0.2351821
Score:  0.157
Data Source:  BioPlex,STRINGDB
GNRHR
Tclin
Family:  GPCR
Novelty:  0.00203671
Score:  0.997
Data Source:  Reactome,STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.995
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.994
Data Source:  STRINGDB
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
79.4
mean platelet volume
2
3
3
73.7
testosterone measurement
2
2
2
70.3
menstrual cycle measurement
1
1
1
67.4
reticulocyte measurement
3
2
3
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
79.4
mean platelet volume
3
73.7
testosterone measurement
2
70.3
menstrual cycle measurement
1
67.4
reticulocyte measurement
3
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gonadotropin releasing hormone 1
VGNC:3010
743992
Macaque
gonadotropin releasing hormone 1
613033
Mouse
MGI:95789
14714
Rat
RGD:2720
25194
Dog
gonadotropin releasing hormone 1
VGNC:41336
608671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gonadotropin releasing hormone 1
Macaque
gonadotropin releasing hormone 1
Mouse
Rat
Dog
gonadotropin releasing hormone 1
Publication Statistics
PubMed Score 5630.19
PubMed score by year
PubTator Score 9799.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title