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Tchem
NGF
Beta-nerve growth factor

Protein Summary
Description
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369512
  • ENSP00000358525
  • ENSG00000134259

Symbol
  • NGFB
  • NGFB
  • HSAN5
  • Beta-NGF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.99
chemical
0.99
gene perturbation
0.93
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13113.24   (req: < 5)
Gene RIFs: 255   (req: <= 3)
Antibodies: 912   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13113.24   (req: >= 5)
Gene RIFs: 255   (req: > 3)
Antibodies: 912   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1397270
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
45.1
diastolic blood pressure
1
1
1
32.9
Diuretic use measurement
1
1
1
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
45.1
diastolic blood pressure
1
32.9
Diuretic use measurement
1
19.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nerve growth factor
VGNC:8424
469423
Mouse
MGI:97321
18049
Rat
RGD:1598328
310738
Dog
nerve growth factor
VGNC:54333
403402
Horse
nerve growth factor
VGNC:20727
100065669
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nerve growth factor
Mouse
Rat
Dog
nerve growth factor
Horse
nerve growth factor
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01138-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (73)
ARMS-mediated activation (R-HSA-170984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARMS-mediated activation
Reactome
Activation of TRKA receptors
Reactome
Axonal growth stimulation
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Ceramide signalling
Name
Explore in Pharos
Explore in Source
ARMS-mediated activation
Activation of TRKA receptors
Axonal growth stimulation
Cell death signalling via NRAGE, NRIF and NADE
Ceramide signalling
Gene Ontology Terms (40)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Genetic Interaction (IGI)
ARUK-UCL
Inferred from Genetic Interaction (IGI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (506)
1 – 10 of 506
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.999
Data Source: Reactome,STRINGDB
NGFR
Tclin
Novelty: 0.00072052
Score: 0.998
Data Source: Reactome,STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.992
Data Source: STRINGDB
SORT1
Tchem
Novelty: 0.00319862
Score: 0.981
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.98
Data Source: STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.976
Data Source: Reactome,STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.973
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.971
Data Source: Reactome,STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.966
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  13113.24

PubMed score by year
PubTator Score  1828.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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