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Tchem
TGFB1
Transforming growth factor beta-1 proprotein

Protein Summary
Description
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix (PubMed:28117447). Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1 (PubMed:2022183, PubMed:8617200, PubMed:8939931, PubMed:19750484, PubMed:22278742, PubMed:19651619). Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (Probable). Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:22278742, PubMed:19651619). Interactio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221930
  • ENSP00000221930
  • ENSG00000105329

Symbol
  • TGFB
  • CED
  • LAP
  • DPD1
  • TGFB
  • IBDIMDE
  • TGFbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
PubMedID
0.95
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6188.55   (req: < 5)
Gene RIFs: 3456   (req: <= 3)
Antibodies: 1690   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6188.55   (req: >= 5)
Gene RIFs: 3456   (req: > 3)
Antibodies: 1690   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 199
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
6
6
1
94.6
1
1
0
1.2
78.9
balding measurement
1
1
1
75.6
alcohol abuse
2
1
2
75.5
liver fibrosis measurement
2
1
2
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
1
94.6
0
1.2
78.9
balding measurement
1
75.6
alcohol abuse
2
75.5
liver fibrosis measurement
2
75.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta 1
VGNC:2232
456060
Macaque
transforming growth factor beta-1
106992315
Mouse
MGI:98725
21803
Rat
RGD:69051
59086
Dog
transforming growth factor beta-1 precursor [Source:RefSeq peptide;Acc:NP_001003309]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta 1
Macaque
transforming growth factor beta-1
Mouse
Rat
Dog
transforming growth factor beta-1 precursor [Source:RefSeq peptide;Acc:NP_001003309]
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01137-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (152)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Deubiquitination
Developmental Biology
Disease
Gene Ontology Terms (212)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
AgBase
Inferred from Mutant Phenotype (IMP)
AgBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (399)
1 – 10 of 399
ERP44
Tbio
Novelty: 0.02352693
p_int: 0.999902852
p_ni: 0.000097148
Data Source: BioPlex
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.999345636
p_ni: 0.000654325
p_wrong: 4e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
LRRC32
Tbio
Novelty: 0.02644086
p_int: 0.998888885
p_ni: 0.001111115
Score: 0.417
Data Source: BioPlex,STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
p_int: 0.998581711
p_ni: 0.001418289
Data Source: BioPlex
NMT1
Tchem
Family: Enzyme
Novelty: 0.00343834
p_int: 0.992551132
p_ni: 0.007448868
Score: 0.175
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.972832822
p_ni: 0.027167178
Data Source: BioPlex
NRROS
Tbio
Novelty: 0.08976002
p_int: 0.962863453
p_ni: 0.037136547
Score: 0.273
Data Source: BioPlex,STRINGDB
LAMC1
Tbio
Novelty: 0.01230796
p_int: 0.904102275
p_ni: 0.095897725
Score: 0.426
Data Source: BioPlex,STRINGDB
C4orf48
Tdark
Novelty: 0.57791774
p_int: 0.873285733
p_ni: 0.126714028
p_wrong: 2.39e-7
Score: 0.516
Data Source: BioPlex,STRINGDB
PNLIPRP2
Tbio
Family: Enzyme
p_int: 0.850553994
p_ni: 0.149446004
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  6188.55

PubMed score by year
PubTator Score  16789.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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