Tbio TGFA Protransforming growth factor alpha

Protein Summary

Description

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P01135
• A8K286
• Q15577
• Q53SK7
• Q9BS56
• Q9UEI3
• Q9UKM1
• Q9UKM2
• Q9UKM3

Gene Name

• TGFA

Ensembl ID

• ENST00000295400
• ENSP00000295400
• ENSG00000163235
• ENST00000418333
• ENSP00000404099
• ENST00000445399
• ENSP00000387493

Symbol

• TFGA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.95
biological term	0.92
chemical	0.84
biological process	0.82
disease	0.82

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Protransforming Growth Factor Alpha

DTO Classes

Protein / Signaling / Growth Factor / Protransforming Growth Factor Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.01   (req: < 5)

Gene RIFs: 141   (req: <= 3)

Antibodies: 1290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.01   (req: >= 5)

Gene RIFs: 141   (req: > 3)

Antibodies: 1290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (211)

Explore Interacting Targets

1 – 10 of 211

• See Interactions on String-DB

RAB5B

Tbio

Family:  Enzyme

Novelty:  0.02653775

p_int:  0.999997016

p_ni:  0.000002983

Data Source:  BioPlex

GPD2

Tbio

Family:  Enzyme

Novelty:  0.00951917

p_int:  0.999479008

p_ni:  0.00052099

p_wrong:  3e-9

Data Source:  BioPlex

PKMYT1

Tchem

Family:  Kinase

Novelty:  0.03025516

p_int:  0.999401604

p_ni:  0.000091055

p_wrong:  0.000507341

Data Source:  BioPlex

DCUN1D5

Tchem

Novelty:  0.56719852

p_int:  0.999338126

p_ni:  0.000602494

p_wrong:  0.00005938

Data Source:  BioPlex

SLC30A1

Tbio

Family:  Transporter

Novelty:  0.00528427

p_int:  0.999085734

p_ni:  0.000912196

p_wrong:  0.00000207

Data Source:  BioPlex

RAC3

Tbio

Family:  Enzyme

Novelty:  0.02125361

p_int:  0.999042348

p_ni:  0.000668705

p_wrong:  0.000288947

Data Source:  BioPlex

MOSPD2

Tbio

Novelty:  0.14602473

p_int:  0.998629952

p_ni:  0.001370048

Data Source:  BioPlex

DHRS3

Tbio

Family:  Enzyme

Novelty:  0.04448013

p_int:  0.998013802

p_ni:  0.001574494

p_wrong:  0.000411704

Data Source:  BioPlex

PI4K2A

Tbio

Family:  Kinase

Novelty:  0.03506675

p_int:  0.997817039

p_ni:  0.002182949

p_wrong:  1.2e-8

Data Source:  BioPlex

PWP2

Tbio

Novelty:  0.04910741

p_int:  0.997246647

p_ni:  0.002753353

Data Source:  BioPlex

Nearest Tclin Targets (7)

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Downstream (7)

1 – 5 of 7

PDGFRB

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  7

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: Prostate cancer

4: Ras signaling pathway

more:  3 more common pathways

FGFR1

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  5

1: PI3K-Akt signaling pathway

2: Prostate cancer

3: Ras signaling pathway

4: MAPK signaling pathway

5: Pathways in cancer

IGF1R

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  8

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: Hepatocellular carcinoma

4: Prostate cancer

more:  4 more common pathways

FGFR2

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  6

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: Prostate cancer

4: Ras signaling pathway

more:  2 more common pathways

EGFR

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  13

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: Non-small cell lung cancer

4: ErbB signaling pathway

more:  9 more common pathways

Pathways (84)

Reactome (48)

KEGG (14)

PathwayCommons (10)

WikiPathways (12)

Asparagine N-linked glycosylation (R-HSA-446203)

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Items per page:

5

1 – 5 of 48

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPII-mediated vesicle transport	68 targets	R-HSA-204005
Reactome	Cargo concentration in the ER	33 targets	R-HSA-5694530
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPII-mediated vesicle transport	68 targets	R-HSA-204005
Cargo concentration in the ER	33 targets	R-HSA-5694530
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (2)

Components (11)

Processes (11)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
epidermal growth factor receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
growth factor activity	Inferred from Direct Assay (IDA)	HGNC

Disease Associations ()

No disease associations found

GWAS Traits (8)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
grip strength measurement	EFO_0006941	4	3	4		78.4
osteoarthritis, hip	EFO_1000786	3	3	0	1.1	77.1
heel bone mineral density	EFO_0009270	2	2	2		69.1
osteoarthritis	EFO_0002506	1	1	0	1.1	66
osteoarthritis, hip, osteoarthritis, knee	EFO_0004616	1	1	0	1.1	57.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
grip strength measurement	EFO_0006941	4		78.4
osteoarthritis, hip	EFO_1000786	0	1.1	77.1
heel bone mineral density	EFO_0009270	2		69.1
osteoarthritis	EFO_0002506	0	1.1	66
osteoarthritis, hip, osteoarthritis, knee	EFO_0004616	0	1.1	57.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Lipoprotein
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
cartilage thickness measurement
grip strength measurement
hair shape measurement
heel bone mineral density
optic disc size measurement
osteoarthritis
osteoarthritis, hip
osteoarthritis, hip, osteoarthritis, knee

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
cardiovascular system phenotype
craniofacial phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
immune system phenotype
integument phenotype
muscle phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transforming growth factor alpha	VGNC:479	737080
Macaque	transforming growth factor alpha		613031
Mouse	transforming growth factor alpha	MGI:98724	21802
Rat	transforming growth factor alpha	RGD:3849	24827
Horse	transforming growth factor alpha	VGNC:51415	100060423

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transforming growth factor alpha
Macaque	transforming growth factor alpha
Mouse	transforming growth factor alpha
Rat	transforming growth factor alpha
Horse	transforming growth factor alpha

Publication Statistics

PubMed Score 294.01

PubMed score by year

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PubTator Score 1086.47

PubTator score by year

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Related Publications

Text Mined References (218)

GeneRif Annotations (141)

Items per page:

10

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PMID	Year	Title