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Tbio
EGF
Pro-epidermal growth factor

Protein Summary
Description
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941). This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265171
  • ENSP00000265171
  • ENSG00000138798
  • ENST00000503392
  • ENSP00000421384
  • ENST00000509793
  • ENSP00000424316

Symbol
  • URG
  • HOMG4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
protein domain
1
disease
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7200.21   (req: < 5)
Gene RIFs: 548   (req: <= 3)
Antibodies: 1242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7200.21   (req: >= 5)
Gene RIFs: 548   (req: > 3)
Antibodies: 1242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
4
4
90.4
monocyte count
3
3
3
86
lymphocyte count
2
1
2
77.8
platelet crit
2
3
3
72.2
epidermal growth factor measurement
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
90.4
monocyte count
3
86
lymphocyte count
2
77.8
platelet crit
3
72.2
epidermal growth factor measurement
1
70.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor
VGNC:10856
461435
Macaque
epidermal growth factor
698619
Mouse
MGI:95290
13645
Dog
epidermal growth factor
VGNC:40235
403657
Horse
epidermal growth factor
VGNC:17456
106782874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor
Macaque
epidermal growth factor
Mouse
Dog
epidermal growth factor
Horse
epidermal growth factor
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (129)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 57
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Constitutive Signaling by EGFRvIII
Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Gene Ontology Terms (56)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (1080)
1 – 10 of 1080
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.999
Data Source: Reactome,STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.996
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.993
Data Source: STRINGDB
IGF1
Tbio
Novelty: 0.00003878
Score: 0.992
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.991
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.99
Data Source: Reactome,STRINGDB
HBEGF
Tbio
Novelty: 0.00105355
Score: 0.989
Data Source: Reactome,STRINGDB
ERBB3
Tclin
Family: Kinase
Novelty: 0.000868
Score: 0.989
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.988
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  7200.21

PubMed score by year
PubTator Score  3945.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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