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Tchem
LDLR
Low-density lipoprotein receptor

Protein Classes
Protein Summary
Description
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (H ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000455727
  • ENSP00000397829
  • ENSG00000130164
  • ENST00000535915
  • ENSP00000440520
  • ENST00000545707
  • ENSP00000437639
  • ENST00000558013
  • ENSP00000453346
  • ENST00000558518
  • ENSP00000454071

Symbol
  • FH
  • FHC
  • LDLCQ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
kinase perturbation
1
protein domain
1
disease perturbation
0.97
disease
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: < 5)
Gene RIFs: 440   (req: <= 3)
Antibodies: 784   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: >= 5)
Gene RIFs: 440   (req: > 3)
Antibodies: 784   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
15
9
18
4.8
99.7
total cholesterol measurement
6
6
11
4.7
98.6
4
3
3
1.1
93.8
2
1
0
1.3
87
alcohol abuse
1
1
1
85.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
18
4.8
99.7
total cholesterol measurement
11
4.7
98.6
3
1.1
93.8
0
1.3
87
alcohol abuse
1
85.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
low density lipoprotein receptor
VGNC:2325
455722
Mouse
MGI:96765
16835
Rat
RGD:2998
300438
Dog
low density lipoprotein receptor
VGNC:42622
100683160
Horse
low density lipoprotein receptor
VGNC:19621
100057389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
low density lipoprotein receptor
Mouse
Rat
Dog
low density lipoprotein receptor
Horse
low density lipoprotein receptor
Protein Structure (33 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01130-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 33
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Chylomicron clearance
Reactome
Clathrin-mediated endocytosis
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Chylomicron clearance
Clathrin-mediated endocytosis
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (66)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (383)
1 – 10 of 383
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.999947934
p_ni: 0.000052044
p_wrong: 2.1e-8
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.997507103
p_ni: 0.002492658
p_wrong: 2.39e-7
Data Source: BioPlex
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.996735209
p_ni: 0.003264772
p_wrong: 1.9e-8
Score: 0.28
Data Source: BioPlex,STRINGDB
LRPAP1
Tbio
Novelty: 0.00214194
p_int: 0.996120581
p_ni: 0.003705287
p_wrong: 0.000174132
Score: 0.77
Data Source: BioPlex,STRINGDB
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.995511065
p_ni: 0.004480635
p_wrong: 0.0000083
Score: 0.336
Data Source: BioPlex,STRINGDB
GINM1
Tdark
Novelty: 1.0701107
p_int: 0.994228422
p_ni: 0.005771576
p_wrong: 1e-9
Data Source: BioPlex
PRG3
Tbio
Novelty: 0.09431986
p_int: 0.99389987
p_ni: 0.005976861
p_wrong: 0.000123269
Data Source: BioPlex
DLK2
Tbio
Novelty: 0.06366405
p_int: 0.990703305
p_ni: 0.009296694
p_wrong: 2e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.987574025
p_ni: 0.009940121
p_wrong: 0.002485854
Data Source: BioPlex
B3GNT2
Tbio
Family: Enzyme
Novelty: 0.02724566
p_int: 0.955880309
p_ni: 0.04411858
p_wrong: 0.000001111
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.02

PubMed score by year
PubTator Score  4403.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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