Tchem LDLR Low-density lipoprotein receptor

Protein Summary

Description

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P01130
• B4DII3
• B4DJZ8
• B4DR00
• B4DTQ3
• C0JYY8
• H0YLU8
• H0YNT7
• Q53ZD9
• Q59FQ1
• Q9UDH7
• LDL receptor

Gene Name

• LDLR

Ensembl ID

• ENST00000455727
• ENSP00000397829
• ENSG00000130164
• ENST00000535915
• ENSP00000440520
• ENST00000545707
• ENSP00000437639
• ENST00000558013
• ENSP00000453346
• ENST00000558518
• ENSP00000454071

Symbol

• FH
• FHC
• LDLCQ2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
kinase perturbation	1
protein domain	1
disease perturbation	0.97
disease	0.94

Protein Classes

DTO Classes

Low-density Lipoprotein Receptor-related Protein 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: < 5)

Gene RIFs: 553   (req: <= 3)

Antibodies: 784   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: >= 5)

Gene RIFs: 553   (req: > 3)

Antibodies: 784   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0