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Tbio
PDGFB
Platelet-derived growth factor subunit B

Protein Summary
Description
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331163
  • ENSP00000330382
  • ENSG00000100311
  • ENST00000381551
  • ENSP00000370963

Symbol
  • PDGF2
  • SIS
  • SIS
  • SSV
  • IBGC5
  • PDGF2
  • c-sis
  • PDGF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.98
chemical
0.92
PubMedID
0.92
cell type or tissue
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1202.76   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 605   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1202.76   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 605   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 73
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
88.7
lymphocyte count
3
1
3
84
3
2
1
1.2
81.4
2
2
0
1.2
81.4
myeloid white cell count
1
1
1
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
88.7
lymphocyte count
3
84
1
1.2
81.4
0
1.2
81.4
myeloid white cell count
1
77.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor subunit B
VGNC:6704
458844
Macaque
platelet derived growth factor subunit B
703173
Mouse
MGI:97528
18591
Rat
RGD:3283
24628
Dog
platelet derived growth factor subunit B
VGNC:44369
442986
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor subunit B
Macaque
platelet derived growth factor subunit B
Mouse
Rat
Dog
platelet derived growth factor subunit B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01127-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (81)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signal transduction
Gene Ontology Terms (83)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (343)
1 – 10 of 343
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.998743525
p_ni:  0.001256475
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.995020906
p_ni:  0.004979094
Data Source:  BioPlex
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.985101216
p_ni:  0.001006473
p_wrong:  0.013892311
Data Source:  BioPlex
ZC3H4
Tbio
Novelty:  0.14897433
p_int:  0.984803783
p_ni:  0.013812442
p_wrong:  0.001383775
Data Source:  BioPlex
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.982918371
p_ni:  0.017081629
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.976854619
p_ni:  0.023145381
Data Source:  BioPlex
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.976098262
p_ni:  0.023901738
Data Source:  BioPlex
MRPS35
Tdark
Novelty:  6.44240335
p_int:  0.970628392
p_ni:  0.029371608
Data Source:  BioPlex
MRPS9
Tdark
Novelty:  0.22906484
p_int:  0.966918028
p_ni:  0.033081972
Data Source:  BioPlex
PTCD3
Tbio
Novelty:  0.12368434
p_int:  0.965241599
p_ni:  0.034758401
Data Source:  BioPlex
Publication Statistics
PubMed Score  1202.76

PubMed score by year
PubTator Score  816.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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