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Tchem
HRAS
GTPase HRas

Protein Summary
Description
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311189
  • ENSP00000309845
  • ENSG00000174775
  • ENST00000397594
  • ENSP00000380722
  • ENST00000397596
  • ENSP00000380723
  • ENST00000417302
  • ENSP00000388246
  • ENST00000451590
  • ENSP00000407586
  • ENST00000493230
  • ENSP00000434023
  • ENST00000610977
  • ENSP00000480686
  • ENSG00000276536
  • ENST00000615062
  • ENSP00000482366
  • ENST00000616241
  • ENSP00000480317
  • ENST00000631404
  • ENSP00000488757
  • ENST00000631967
  • ENSP00000488225
  • ENST00000634098
  • ENSP00000488296

Symbol
  • HRAS1
  • CTLO
  • KRAS
  • HAMSV
  • HRAS1
  • KRAS2
  • RASH1
  • RASK2
  • Ki-Ras
  • p21ras
  • C-H-RAS
  • c-K-ras
  • H-RASIDX
  • c-Ki-ras
  • C-BAS/HAS
  • C-HA-RAS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
pathway
1
chemical
0.99
hub protein
0.99
phenotype
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10062.77   (req: < 5)
Gene RIFs: 463   (req: <= 3)
Antibodies: 683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10062.77   (req: >= 5)
Gene RIFs: 463   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
stallimycin
chemical structure image
Protein Data Bank (168)
1 – 5 of 168
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (334)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 126
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Activated NTRK2 signals through RAS
Reactome
Activated NTRK3 signals through RAS
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAS in B cells
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through RAS
Activated NTRK3 signals through RAS
Activation of NMDA receptors and postsynaptic events
Activation of RAS in B cells
Gene Ontology Terms (57)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
WormBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (1037)
1 – 10 of 1037
RIN1
Tbio
Novelty: 0.02228321
p_int: 0.999920775
p_ni: 0.000079225
Score: 0.964
Data Source: BioPlex,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00382184
p_int: 0.998682404
p_ni: 0.001317591
p_wrong: 5e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.13346044
p_int: 0.994792299
p_ni: 0.005207631
p_wrong: 7e-8
Score: 0.263
Data Source: BioPlex,STRINGDB
RGL1
Tbio
Novelty: 0.01382117
p_int: 0.992532424
p_ni: 0.007165967
p_wrong: 0.000301609
Score: 0.948
Data Source: BioPlex,STRINGDB
TMEM185A
Tdark
Novelty: 0.03619125
p_int: 0.992224121
p_ni: 0.007775844
p_wrong: 3.5e-8
Score: 0.285
Data Source: BioPlex,STRINGDB
CYP2S1
Tbio
Novelty: 0.04038753
p_int: 0.989422085
p_ni: 0.010577901
p_wrong: 1.4e-8
Score: 0.295
Data Source: BioPlex,STRINGDB
DUSP22
Tbio
Family: Enzyme
Novelty: 0.02012116
p_int: 0.981653786
p_ni: 0.018345936
p_wrong: 2.77e-7
Score: 0.261
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 2.02597403
p_int: 0.977822329
p_ni: 0.015359264
p_wrong: 0.006818408
Data Source: BioPlex
ATG3
Tbio
Novelty: 0.00966067
p_int: 0.977406914
p_ni: 0.020816048
p_wrong: 0.001777038
Score: 0.32
Data Source: BioPlex,STRINGDB
VDAC3
Tbio
Novelty: 0.01448609
p_int: 0.977028169
p_ni: 0.022970652
p_wrong: 0.000001179
Score: 0.459
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10062.77

PubMed score by year
PubTator Score  1772.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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