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Tchem
HRAS
GTPase HRas

Protein Summary
Description
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311189
  • ENSP00000309845
  • ENSG00000174775
  • ENST00000397594
  • ENSP00000380722
  • ENST00000397596
  • ENSP00000380723
  • ENST00000417302
  • ENSP00000388246
  • ENST00000451590
  • ENSP00000407586
  • ENST00000493230
  • ENSP00000434023
  • ENST00000610977
  • ENSP00000480686
  • ENSG00000276536
  • ENST00000615062
  • ENSP00000482366
  • ENST00000616241
  • ENSP00000480317
  • ENST00000631404
  • ENSP00000488757
  • ENST00000631967
  • ENSP00000488225
  • ENST00000634098
  • ENSP00000488296

Symbol
  • HRAS1
  • CTLO
  • KRAS
  • HAMSV
  • HRAS1
  • KRAS2
  • RASH1
  • RASK2
  • Ki-Ras
  • p21ras
  • C-H-RAS
  • c-K-ras
  • H-RASIDX
  • c-Ki-ras
  • C-BAS/HAS
  • C-HA-RAS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
pathway
1
chemical
0.99
hub protein
0.99
phenotype
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13112.46   (req: < 5)
Gene RIFs: 463   (req: <= 3)
Antibodies: 683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13112.46   (req: >= 5)
Gene RIFs: 463   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (1037)
RIN1
Tbio
Novelty:  0.02401084
p_int:  0.999920775
p_ni:  0.000079225
Score:  0.964
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.998682404
p_ni:  0.001317591
p_wrong:  5e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.994792299
p_ni:  0.005207631
p_wrong:  7e-8
Score:  0.263
Data Source:  BioPlex,STRINGDB
RGL1
Tbio
Novelty:  0.0095933
p_int:  0.992532424
p_ni:  0.007165967
p_wrong:  0.000301609
Score:  0.948
Data Source:  BioPlex,STRINGDB
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.992224121
p_ni:  0.007775844
p_wrong:  3.5e-8
Score:  0.285
Data Source:  BioPlex,STRINGDB
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.989422085
p_ni:  0.010577901
p_wrong:  1.4e-8
Score:  0.295
Data Source:  BioPlex,STRINGDB
DUSP22
Tbio
Family:  Enzyme
Novelty:  0.01579003
p_int:  0.981653786
p_ni:  0.018345936
p_wrong:  2.77e-7
Score:  0.261
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.977822329
p_ni:  0.015359264
p_wrong:  0.006818408
Data Source:  BioPlex
ATG3
Tbio
Novelty:  0.00541077
p_int:  0.977406914
p_ni:  0.020816048
p_wrong:  0.001777038
Score:  0.32
Data Source:  BioPlex,STRINGDB
VDAC3
Tbio
Novelty:  0.0095068
p_int:  0.977028169
p_ni:  0.022970652
p_wrong:  0.000001179
Score:  0.459
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (25)
Explore Nearest Tclin Targets
1 – 5 of 20
KIT
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  10
more:  6 more common pathways
FGFR1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  13
more:  9 more common pathways
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  22
more:  18 more common pathways
Pathways (334)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

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Find Similar Targets
Items per page:
1 – 5 of 126
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Activated NTRK2 signals through RAS
Reactome
Activated NTRK3 signals through RAS
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAS in B cells
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through RAS
Activated NTRK3 signals through RAS
Activation of NMDA receptors and postsynaptic events
Activation of RAS in B cells
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
0
1.2
91.3
reticulocyte measurement
2
2
2
64.4
2
2
0
1.2
46.9
reticulocyte count
1
1
1
11.2
1
1
0
1.1
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.3
reticulocyte measurement
2
64.4
0
1.2
46.9
reticulocyte count
1
11.2
0
1.1
9.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HRas proto-oncogene, GTPase
VGNC:50562
466302
Macaque
HRas proto-oncogene, GTPase
698830
Mouse
MGI:96224
15461
Rat
RGD:2827
293621
Horse
HRas proto-oncogene, GTPase
VGNC:18868
100055481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HRas proto-oncogene, GTPase
Macaque
HRas proto-oncogene, GTPase
Mouse
Rat
Horse
HRas proto-oncogene, GTPase
Publication Statistics
PubMed Score 13112.46
PubMed score by year
PubTator Score 1772.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title