Tchem HRAS GTPase HRas

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Hras

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Hras

Protein Summary

Description

Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01112
• B5BUA0
• Q14080
• Q6FHV9
• Q9BR65
• Q9UCE2

Gene Name

• HRAS

Ensembl ID

• ENST00000311189
• ENSP00000309845
• ENSG00000174775
• ENST00000397594
• ENSP00000380722
• ENST00000397596
• ENSP00000380723
• ENST00000417302
• ENSP00000388246
• ENST00000451590
• ENSP00000407586
• ENST00000493230
• ENSP00000434023
• ENST00000610977
• ENSP00000480686
• ENSG00000276536
• ENST00000615062
• ENSP00000482366
• ENST00000616241
• ENSP00000480317
• ENST00000631404
• ENSP00000488757
• ENST00000631967
• ENSP00000488225
• ENST00000634098
• ENSP00000488296

Symbol

• HRAS1
• CTLO
• KRAS
• HAMSV
• HRAS1
• KRAS2
• RASH1
• RASK2
• Ki-Ras
• p21ras
• C-H-RAS
• c-K-ras
• H-RASIDX
• c-Ki-ras
• C-BAS/HAS
• C-HA-RAS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
pathway	1
chemical	0.99
hub protein	0.99
phenotype	0.94

Related Tools

GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12696.97   (req: < 5)

Gene RIFs: 463   (req: <= 3)

Antibodies: 683   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12696.97   (req: >= 5)

Gene RIFs: 463   (req: > 3)

Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

stallimycin

HRASTchem Enzyme

IC50 : 6.7

Active Ligands (9)

Explore Active Ligands

1 – 9 of 9

lonafarnib

HRASTchem Enzyme

IC50 : 8.72000027

CHEMBL304462

HRASTchem Enzyme

IC50 : 6

CHEMBL536328

HRASTchem Enzyme

IC50 : 7.7

CHEMBL552863

HRASTchem Enzyme

IC50 : 7.7

CHEMBL554353

HRASTchem Enzyme

IC50 : 7.82

CHEMBL554189

HRASTchem Enzyme

IC50 : 7.82

CHEMBL552690

HRASTchem Enzyme

IC50 : 7.82

CHEMBL554247

HRASTchem Enzyme

IC50 : 7.82

CHEMBL540313

HRASTchem Enzyme

IC50 : 7.82

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	HRas proto-oncogene, GTPase	VGNC:50562	466302
Macaque	HRas proto-oncogene, GTPase		698830
Mouse	Harvey rat sarcoma virus oncogene	MGI:96224	15461
Rat	HRas proto-oncogene, GTPase	RGD:2827	293621
Horse	HRas proto-oncogene, GTPase	VGNC:18868	100055481

Species	Name	OMA	EggNOG	Inparanoid
Chimp	HRas proto-oncogene, GTPase
Macaque	HRas proto-oncogene, GTPase
Mouse	Harvey rat sarcoma virus oncogene
Rat	HRas proto-oncogene, GTPase
Horse	HRas proto-oncogene, GTPase

Protein Structure (168 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01112-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 168

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (334)

Reactome (126)

KEGG (77)

PathwayCommons (72)

WikiPathways (59)

Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

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Find Similar Targets

Items per page:

5

1 – 5 of 126

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated NTRK2 signals through FRS2 and FRS3	11 targets	R-HSA-9028731
Reactome	Activated NTRK2 signals through RAS	9 targets	R-HSA-9026519
Reactome	Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Activation of RAS in B cells	5 targets	R-HSA-1169092

Name	Explore in Pharos	Explore in Source
Activated NTRK2 signals through FRS2 and FRS3	11 targets	R-HSA-9028731
Activated NTRK2 signals through RAS	9 targets	R-HSA-9026519
Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Activation of RAS in B cells	5 targets	R-HSA-1169092

Gene Ontology Terms (57)

Functions (4)

Components (8)

Processes (45)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
GTP binding	Inferred from Direct Assay (IDA)	UniProtKB
GTPase activity	Inferred from Direct Assay (IDA)	WormBase
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
GDP binding	Inferred from Mutant Phenotype (IMP)	CAFA

Protein-Protein Interactions (1037)

Explore Interacting Targets

1 – 10 of 1037

• See Interactions on String-DB

RIN1

Tbio

Novelty: 0.02401084

p_int: 0.999920775

p_ni: 0.000079225

Score: 0.964

Data Source: BioPlex,STRINGDB

BRAF

Tclin

Family: Kinase

Novelty: 0.00253795

p_int: 0.998682404

p_ni: 0.001317591

p_wrong: 5e-9

Score: 0.997

Data Source: BioPlex,Reactome,STRINGDB

RABGGTB

Tbio

Family: Enzyme

Novelty: 0.06786314

p_int: 0.994792299

p_ni: 0.005207631

p_wrong: 7e-8

Score: 0.263

Data Source: BioPlex,STRINGDB

RGL1

Tbio

Novelty: 0.0095933

p_int: 0.992532424

p_ni: 0.007165967

p_wrong: 0.000301609

Score: 0.948

Data Source: BioPlex,STRINGDB

TMEM185A

Tdark

Novelty: 0.0262898

p_int: 0.992224121

p_ni: 0.007775844

p_wrong: 3.5e-8

Score: 0.285

Data Source: BioPlex,STRINGDB

CYP2S1

Tbio

Novelty: 0.02967417

p_int: 0.989422085

p_ni: 0.010577901

p_wrong: 1.4e-8

Score: 0.295

Data Source: BioPlex,STRINGDB

DUSP22

Tbio

Family: Enzyme

Novelty: 0.01579003

p_int: 0.981653786

p_ni: 0.018345936

p_wrong: 2.77e-7

Score: 0.261

Data Source: BioPlex,STRINGDB

SLC25A41

Tdark

Family: Transporter

Novelty: 1.04918395

p_int: 0.977822329

p_ni: 0.015359264

p_wrong: 0.006818408

Data Source: BioPlex

ATG3

Tbio

Novelty: 0.00541077

p_int: 0.977406914

p_ni: 0.020816048

p_wrong: 0.001777038

Score: 0.32

Data Source: BioPlex,STRINGDB

VDAC3

Tbio

Novelty: 0.0095068

p_int: 0.977028169

p_ni: 0.022970652

p_wrong: 0.000001179

Score: 0.459

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  12696.97

PubMed score by year

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PubTator Score  1772.19

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Cell membrane
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Golgi apparatus
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MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype