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Tchem
HRAS
GTPase HRas

Protein Summary
Description
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311189
  • ENSP00000309845
  • ENSG00000174775
  • ENST00000397594
  • ENSP00000380722
  • ENST00000397596
  • ENSP00000380723
  • ENST00000417302
  • ENSP00000388246
  • ENST00000451590
  • ENSP00000407586
  • ENST00000493230
  • ENSP00000434023
  • ENST00000610977
  • ENSP00000480686
  • ENSG00000276536
  • ENST00000615062
  • ENSP00000482366
  • ENST00000616241
  • ENSP00000480317
  • ENST00000631404
  • ENSP00000488757
  • ENST00000631967
  • ENSP00000488225
  • ENST00000634098
  • ENSP00000488296

Symbol
  • HRAS1
  • CTLO
  • KRAS
  • HAMSV
  • HRAS1
  • KRAS2
  • RASH1
  • RASK2
  • Ki-Ras
  • p21ras
  • C-H-RAS
  • c-K-ras
  • H-RASIDX
  • c-Ki-ras
  • C-BAS/HAS
  • C-HA-RAS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
pathway
1
chemical
0.99
hub protein
0.99
phenotype
0.94


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12696.97   (req: < 5)
View Publications
Gene RIFs: 463   (req: <= 3)
View Gene RIFs
Antibodies: 683   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12696.97   (req: >= 5)
Gene RIFs: 463   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Explore Approved Drugs
Approved Drugs (1)
1 – 1 of 1
stallimycin
chemical structure image
HRASTchem Enzyme


IC50 : 6.7

Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HRas proto-oncogene, GTPase
VGNC:50562
466302
Macaque
HRas proto-oncogene, GTPase
698830
Mouse
Harvey rat sarcoma virus oncogene
MGI:96224
15461
Rat
HRas proto-oncogene, GTPase
RGD:2827
293621
Horse
HRas proto-oncogene, GTPase
VGNC:18868
100055481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HRas proto-oncogene, GTPase
Macaque
HRas proto-oncogene, GTPase
Mouse
Harvey rat sarcoma virus oncogene
Rat
HRas proto-oncogene, GTPase
Horse
HRas proto-oncogene, GTPase
Protein Data Bank (168)
1 – 5 of 168
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (334)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 126
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
11 targets
R-HSA-9028731
Reactome
Activated NTRK2 signals through RAS
9 targets
R-HSA-9026519
Reactome
Activated NTRK3 signals through RAS
8 targets
R-HSA-9034864
Reactome
Activation of NMDA receptors and postsynaptic events
74 targets
R-HSA-442755
Reactome
Activation of RAS in B cells
5 targets
R-HSA-1169092
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
11 targets
R-HSA-9028731
Activated NTRK2 signals through RAS
9 targets
R-HSA-9026519
Activated NTRK3 signals through RAS
8 targets
R-HSA-9034864
Activation of NMDA receptors and postsynaptic events
74 targets
R-HSA-442755
Activation of RAS in B cells
5 targets
R-HSA-1169092
Gene Ontology Terms (57)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
GTP binding
Inferred from Direct Assay (IDA)
UniProtKB
GTPase activity
Inferred from Direct Assay (IDA)
WormBase
protein C-terminus binding
Inferred from Physical Interaction (IPI)
UniProtKB
GDP binding
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (1037)
1 – 10 of 1037
RIN1
Tbio
Novelty: 0.02401084
p_int: 0.999920775
p_ni: 0.000079225
Score: 0.964
Data Source: BioPlex,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.998682404
p_ni: 0.001317591
p_wrong: 5e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
p_int: 0.994792299
p_ni: 0.005207631
p_wrong: 7e-8
Score: 0.263
Data Source: BioPlex,STRINGDB
RGL1
Tbio
Novelty: 0.0095933
p_int: 0.992532424
p_ni: 0.007165967
p_wrong: 0.000301609
Score: 0.948
Data Source: BioPlex,STRINGDB
TMEM185A
Tdark
Novelty: 0.0262898
p_int: 0.992224121
p_ni: 0.007775844
p_wrong: 3.5e-8
Score: 0.285
Data Source: BioPlex,STRINGDB
CYP2S1
Tbio
Novelty: 0.02967417
p_int: 0.989422085
p_ni: 0.010577901
p_wrong: 1.4e-8
Score: 0.295
Data Source: BioPlex,STRINGDB
DUSP22
Tbio
Family: Enzyme
Novelty: 0.01579003
p_int: 0.981653786
p_ni: 0.018345936
p_wrong: 2.77e-7
Score: 0.261
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.977822329
p_ni: 0.015359264
p_wrong: 0.006818408
Data Source: BioPlex
ATG3
Tbio
Novelty: 0.00541077
p_int: 0.977406914
p_ni: 0.020816048
p_wrong: 0.001777038
Score: 0.32
Data Source: BioPlex,STRINGDB
VDAC3
Tbio
Novelty: 0.0095068
p_int: 0.977028169
p_ni: 0.022970652
p_wrong: 0.000001179
Score: 0.459
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12696.97

PubMed score by year
PubTator Score  1772.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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