Protein Summary
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated ...more
- ENST00000311189
- ENSP00000309845
- ENSG00000174775
- ENST00000397594
- ENSP00000380722
- ENST00000397596
- ENSP00000380723
- ENST00000417302
- ENSP00000388246
- ENST00000451590
- ENSP00000407586
- ENST00000493230
- ENSP00000434023
- ENST00000610977
- ENSP00000480686
- ENSG00000276536
- ENST00000615062
- ENSP00000482366
- ENST00000616241
- ENSP00000480317
- ENST00000631404
- ENSP00000488757
- ENST00000631967
- ENSP00000488225
- ENST00000634098
- ENSP00000488296
- HRAS1
- CTLO
- KRAS
- HAMSV
- HRAS1
- KRAS2
- RASH1
- RASK2
- Ki-Ras
- p21ras
- C-H-RAS
- c-K-ras
- H-RASIDX
- c-Ki-ras
- C-BAS/HAS
- C-HA-RAS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
pathway | 1 | ||
chemical | 0.99 | ||
hub protein | 0.99 | ||
phenotype | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13112.46 (req: < 5)
Gene RIFs: 463 (req: <= 3)
Antibodies: 683 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13112.46 (req: >= 5)
Gene RIFs: 463 (req: > 3)
Antibodies: 683 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 49
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (19)
Protein-Protein Interactions (1037)
RIN1
Novelty: 0.02401084
p_int: 0.999920775
p_ni: 0.000079225
Score: 0.964
Data Source: BioPlex,STRINGDB
BRAF
Family: Kinase
Novelty: 0.00253795
p_int: 0.998682404
p_ni: 0.001317591
p_wrong: 5e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RABGGTB
Family: Enzyme
Novelty: 0.06786314
p_int: 0.994792299
p_ni: 0.005207631
p_wrong: 7e-8
Score: 0.263
Data Source: BioPlex,STRINGDB
RGL1
Novelty: 0.0095933
p_int: 0.992532424
p_ni: 0.007165967
p_wrong: 0.000301609
Score: 0.948
Data Source: BioPlex,STRINGDB
TMEM185A
Novelty: 0.0262898
p_int: 0.992224121
p_ni: 0.007775844
p_wrong: 3.5e-8
Score: 0.285
Data Source: BioPlex,STRINGDB
CYP2S1
Novelty: 0.02967417
p_int: 0.989422085
p_ni: 0.010577901
p_wrong: 1.4e-8
Score: 0.295
Data Source: BioPlex,STRINGDB
DUSP22
Family: Enzyme
Novelty: 0.01579003
p_int: 0.981653786
p_ni: 0.018345936
p_wrong: 2.77e-7
Score: 0.261
Data Source: BioPlex,STRINGDB
SLC25A41
Family: Transporter
Novelty: 1.04918395
p_int: 0.977822329
p_ni: 0.015359264
p_wrong: 0.006818408
Data Source: BioPlex
ATG3
Novelty: 0.00541077
p_int: 0.977406914
p_ni: 0.020816048
p_wrong: 0.001777038
Score: 0.32
Data Source: BioPlex,STRINGDB
VDAC3
Novelty: 0.0095068
p_int: 0.977028169
p_ni: 0.022970652
p_wrong: 0.000001179
Score: 0.459
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (25)
Upstream (20)
Downstream (5)
1 – 5 of 20
FGFR1
Pathways (334)
Reactome (126)
KEGG (77)
PathwayCommons (72)
WikiPathways (59)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NTRK2 signals through FRS2 and FRS3 | ||||
Reactome | Activated NTRK2 signals through RAS | ||||
Reactome | Activated NTRK3 signals through RAS | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Activation of RAS in B cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NTRK2 signals through FRS2 and FRS3 | ||||
Activated NTRK2 signals through RAS | ||||
Activated NTRK3 signals through RAS | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Activation of RAS in B cells | ||||
Viral Interactions (0)
Gene Ontology Terms (57)
Functions (4)
Components (8)
Processes (45)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
8 | 7 | 0 | 1.2 | 91.3 | |||||
reticulocyte measurement | 2 | 2 | 2 | 64.4 | |||||
2 | 2 | 0 | 1.2 | 46.9 | |||||
reticulocyte count | 1 | 1 | 1 | 11.2 | |||||
1 | 1 | 0 | 1.1 | 9.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 91.3 | |||||
reticulocyte measurement | 2 | 64.4 | |||||
0 | 1.2 | 46.9 | |||||
reticulocyte count | 1 | 11.2 | |||||
0 | 1.1 | 9.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | HRas proto-oncogene, GTPase | VGNC:50562 | 466302 | |||||
Macaque | HRas proto-oncogene, GTPase | 698830 | ||||||
Mouse | MGI:96224 | 15461 | ||||||
Rat | RGD:2827 | 293621 | ||||||
Horse | HRas proto-oncogene, GTPase | VGNC:18868 | 100055481 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | HRas proto-oncogene, GTPase | |||||
Macaque | HRas proto-oncogene, GTPase | |||||
Mouse | ||||||
Rat | ||||||
Horse | HRas proto-oncogene, GTPase | |||||
Publication Statistics
PubMed Score 13112.46
PubMed score by year
PubTator Score 1772.19
PubTator score by year
Related Publications
Text Mined References (666)
GeneRif Annotations (463)
Items per page:
0 of 0
PMID | Year | Title |
---|