Protein Summary
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
- ENST00000369535
- ENSP00000358548
- ENSG00000213281
- HRAS1
- NS6
- CMNS
- NCMS
- ALPS4
- N-ras
- NRAS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
pathway | 0.99 | ||
biological term | 0.98 | ||
biological process | 0.97 | ||
disease perturbation | 0.96 | ||
interacting protein | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1155.01 (req: < 5)
Gene RIFs: 390 (req: <= 3)
Antibodies: 461 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1155.01 (req: >= 5)
Gene RIFs: 390 (req: > 3)
Antibodies: 461 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (1)
Protein-Protein Interactions (581)
RIN1
Novelty: 0.02401084
p_int: 0.999946804
p_ni: 0.000053196
Score: 0.937
Data Source: BioPlex,STRINGDB
ABHD5
Family: Enzyme
Novelty: 0.00806614
p_int: 0.998478773
p_ni: 0.001520998
p_wrong: 2.29e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
RGL1
Novelty: 0.0095933
p_int: 0.992725058
p_ni: 0.007274634
p_wrong: 3.08e-7
Score: 0.92
Data Source: BioPlex,STRINGDB
RABGGTB
Family: Enzyme
Novelty: 0.06786314
p_int: 0.970552236
p_ni: 0.029447763
p_wrong: 1e-9
Score: 0.282
Data Source: BioPlex,STRINGDB
SLC39A12
Family: Transporter
Novelty: 0.09127395
p_int: 0.959639932
p_ni: 0.040360068
Data Source: BioPlex
SCGB2A1
Novelty: 0.01902973
p_int: 0.912697979
p_ni: 0.087302019
p_wrong: 1e-9
Data Source: BioPlex
ADGRE5
Family: GPCR
Novelty: 0.01137558
p_int: 0.900048538
p_ni: 0.099922128
p_wrong: 0.000029334
Data Source: BioPlex
SLC4A8
Family: Transporter
Novelty: 0.01606111
p_int: 0.898060166
p_ni: 0.082289085
p_wrong: 0.019650749
Data Source: BioPlex
RTN1
Novelty: 0.01828064
p_int: 0.875353253
p_ni: 0.124605601
p_wrong: 0.000041145
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (25)
Upstream (20)
Downstream (5)
1 – 5 of 20
Pathways (313)
Reactome (125)
KEGG (74)
PathwayCommons (53)
WikiPathways (61)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NTRK2 signals through FRS2 and FRS3 | ||||
Reactome | Activated NTRK2 signals through RAS | ||||
Reactome | Activated NTRK3 signals through RAS | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Activation of RAS in B cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NTRK2 signals through FRS2 and FRS3 | ||||
Activated NTRK2 signals through RAS | ||||
Activated NTRK3 signals through RAS | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Activation of RAS in B cells | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 37.6 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 21.5 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 2.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 1 | 37.6 | |||||
comparative body size at age 10, self-reported | 1 | 21.5 | |||||
age at first sexual intercourse measurement | 1 | 2.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NRAS proto-oncogene, GTPase | VGNC:10029 | 742713 | |||||
Macaque | NRAS proto-oncogene, GTPase | 709089 | ||||||
Mouse | MGI:97376 | 18176 | ||||||
Rat | RGD:3205 | 24605 | ||||||
Dog | NRAS proto-oncogene, GTPase | VGNC:43959 | 403872 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NRAS proto-oncogene, GTPase | |||||
Macaque | NRAS proto-oncogene, GTPase | |||||
Mouse | ||||||
Rat | ||||||
Dog | NRAS proto-oncogene, GTPase | |||||
Publication Statistics
PubMed Score 1155.01
PubMed score by year
PubTator Score 1389.42
PubTator score by year
Related Publications
Text Mined References (469)
GeneRif Annotations (390)
Items per page:
0 of 0
PMID | Year | Title |
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