NRAS
GTPase NRas
Protein Summary
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
- ENST00000369535
- ENSP00000358548
- ENSG00000213281
- HRAS1
- NS6
- CMNS
- NCMS
- ALPS4
- N-ras
- NRAS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.99 | ||
biological term | 0.98 | ||
biological process | 0.97 | ||
disease perturbation | 0.96 | ||
interacting protein | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1325.58 (req: < 5)
Gene RIFs: 500 (req: <= 3)
Antibodies: 461 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1325.58 (req: >= 5)
Gene RIFs: 500 (req: > 3)
Antibodies: 461 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1