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Tchem
NRAS
GTPase NRas

Protein Summary
Description
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369535
  • ENSP00000358548
  • ENSG00000213281

Symbol
  • HRAS1
  • NS6
  • CMNS
  • NCMS
  • ALPS4
  • N-ras
  • NRAS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
biological term
0.98
biological process
0.97
disease perturbation
0.96
interacting protein
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.01   (req: < 5)
Gene RIFs: 390   (req: <= 3)
Antibodies: 461   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.01   (req: >= 5)
Gene RIFs: 390   (req: > 3)
Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lonafarnib
Rendered image for lonafarnib
Active Ligands (1)
1 – 1 of 1
CHEMBL2086789
Rendered image for CHEMBL2086789
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
37.6
comparative body size at age 10, self-reported
1
1
1
21.5
age at first sexual intercourse measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
37.6
comparative body size at age 10, self-reported
1
21.5
age at first sexual intercourse measurement
1
2.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NRAS proto-oncogene, GTPase
VGNC:10029
742713
Macaque
NRAS proto-oncogene, GTPase
709089
Mouse
MGI:97376
18176
Rat
RGD:3205
24605
Dog
NRAS proto-oncogene, GTPase
VGNC:43959
403872
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NRAS proto-oncogene, GTPase
Macaque
NRAS proto-oncogene, GTPase
Mouse
Rat
Dog
NRAS proto-oncogene, GTPase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01111-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (313)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 125
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Activated NTRK2 signals through RAS
Reactome
Activated NTRK3 signals through RAS
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAS in B cells
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through RAS
Activated NTRK3 signals through RAS
Activation of NMDA receptors and postsynaptic events
Activation of RAS in B cells
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (581)
1 – 10 of 581
RIN1
Tbio
Novelty:  0.02401084
p_int:  0.999946804
p_ni:  0.000053196
Score:  0.937
Data Source:  BioPlex,STRINGDB
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
p_int:  0.998478773
p_ni:  0.001520998
p_wrong:  2.29e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
RGL1
Tbio
Novelty:  0.0095933
p_int:  0.992725058
p_ni:  0.007274634
p_wrong:  3.08e-7
Score:  0.92
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.970552236
p_ni:  0.029447763
p_wrong:  1e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.959639932
p_ni:  0.040360068
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.912697979
p_ni:  0.087302019
p_wrong:  1e-9
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.905887537
p_ni:  0.094112463
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.900048538
p_ni:  0.099922128
p_wrong:  0.000029334
Data Source:  BioPlex
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
p_int:  0.898060166
p_ni:  0.082289085
p_wrong:  0.019650749
Data Source:  BioPlex
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.875353253
p_ni:  0.124605601
p_wrong:  0.000041145
Score:  0.2
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1155.01

PubMed score by year
PubTator Score  1389.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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