Tchem NRAS GTPase NRas

Protein Summary

Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• P01111
• Q14971
• Q15104
• Q15282

Gene Name

• NRAS

Ensembl ID

• ENST00000369535
• ENSP00000358548
• ENSG00000213281

Symbol

• HRAS1
• NS6
• CMNS
• NCMS
• ALPS4
• N-ras
• NRAS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
biological term	0.98
biological process	0.97
disease perturbation	0.96
interacting protein	0.94

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Nras

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Nras

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.01   (req: < 5)

Gene RIFs: 390   (req: <= 3)

Antibodies: 461   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.01   (req: >= 5)

Gene RIFs: 390   (req: > 3)

Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

lonafarnib

NRASTchem Enzyme

INHIBITOR pIC50 : 8.55

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL2086789

NRASTchem Enzyme

pIC50 : 6.3

Protein-Protein Interactions (581)

Explore Interacting Targets

1 – 10 of 581

• See Interactions on String-DB

RIN1

Tbio

Novelty:  0.02401084

p_int:  0.999946804

p_ni:  0.000053196

Score:  0.937

Data Source:  BioPlex,STRINGDB

ABHD5

Tbio

Family:  Enzyme

Novelty:  0.00806614

p_int:  0.998478773

p_ni:  0.001520998

p_wrong:  2.29e-7

Score:  0.185

Data Source:  BioPlex,STRINGDB

RGL1

Tbio

Novelty:  0.0095933

p_int:  0.992725058

p_ni:  0.007274634

p_wrong:  3.08e-7

Score:  0.92

Data Source:  BioPlex,STRINGDB

RABGGTB

Tbio

Family:  Enzyme

Novelty:  0.06786314

p_int:  0.970552236

p_ni:  0.029447763

p_wrong:  1e-9

Score:  0.282

Data Source:  BioPlex,STRINGDB

SLC39A12

Tbio

Family:  Transporter

Novelty:  0.09127395

p_int:  0.959639932

p_ni:  0.040360068

Data Source:  BioPlex

SCGB2A1

Tbio

Novelty:  0.01902973

p_int:  0.912697979

p_ni:  0.087302019

p_wrong:  1e-9

Data Source:  BioPlex

TMEM185A

Tdark

Novelty:  0.0262898

p_int:  0.905887537

p_ni:  0.094112463

Data Source:  BioPlex

ADGRE5

Tbio

Family:  GPCR

Novelty:  0.01137558

p_int:  0.900048538

p_ni:  0.099922128

p_wrong:  0.000029334

Data Source:  BioPlex

SLC4A8

Tbio

Family:  Transporter

Novelty:  0.01606111

p_int:  0.898060166

p_ni:  0.082289085

p_wrong:  0.019650749

Data Source:  BioPlex

RTN1

Tbio

Novelty:  0.01828064

p_int:  0.875353253

p_ni:  0.124605601

p_wrong:  0.000041145

Score:  0.2

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (25)

Explore Nearest Tclin Targets

Upstream (20)

Downstream (5)

1 – 5 of 20

PDGFRA

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  16

1: PI3K-Akt signaling pathway

2: Central carbon metabolism in cancer

3: EGFR tyrosine kinase inhibitor resistance

4: Choline metabolism in cancer

more:  12 more common pathways

IGF1R

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  20

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: Endocrine resistance

4: mTOR signaling pathway

more:  16 more common pathways

PDGFRB

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  16

1: PI3K-Akt signaling pathway

2: Central carbon metabolism in cancer

3: EGFR tyrosine kinase inhibitor resistance

4: Choline metabolism in cancer

more:  12 more common pathways

FGFR2

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  11

1: PI3K-Akt signaling pathway

2: Central carbon metabolism in cancer

3: EGFR tyrosine kinase inhibitor resistance

4: Gastric cancer

more:  7 more common pathways

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  60

1: PI3K-Akt signaling pathway

2: Central carbon metabolism in cancer

3: Axon guidance

4: EGFR tyrosine kinase inhibitor resistance

more:  56 more common pathways

Pathways (313)

Reactome (125)

KEGG (74)

PathwayCommons (53)

WikiPathways (61)

Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

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Items per page:

5

1 – 5 of 125

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated NTRK2 signals through FRS2 and FRS3	11 targets	R-HSA-9028731
Reactome	Activated NTRK2 signals through RAS	9 targets	R-HSA-9026519
Reactome	Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Activation of RAS in B cells	5 targets	R-HSA-1169092

Name	Explore in Pharos	Explore in Source
Activated NTRK2 signals through FRS2 and FRS3	11 targets	R-HSA-9028731
Activated NTRK2 signals through RAS	9 targets	R-HSA-9026519
Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Activation of RAS in B cells	5 targets	R-HSA-1169092

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (3)

Components (6)

Processes (5)

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1 – 3 of 3

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	MGI
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		37.6
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		21.5
age at first sexual intercourse measurement	EFO_0009749	1	1	1		2.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		37.6
comparative body size at age 10, self-reported	EFO_0009819	1		21.5
age at first sexual intercourse measurement	EFO_0009749	1		2.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cell membrane
Complete proteome
Disease mutation
Golgi apparatus
GTP-binding
Lipoprotein
Membrane
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
body height
comparative body size at age 10, self-reported

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
craniofacial phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
limbs/digits/tail phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NRAS proto-oncogene, GTPase	VGNC:10029	742713
Macaque	NRAS proto-oncogene, GTPase		709089
Mouse	neuroblastoma ras oncogene	MGI:97376	18176
Rat	NRAS proto-oncogene, GTPase	RGD:3205	24605
Dog	NRAS proto-oncogene, GTPase	VGNC:43959	403872

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NRAS proto-oncogene, GTPase
Macaque	NRAS proto-oncogene, GTPase
Mouse	neuroblastoma ras oncogene
Rat	NRAS proto-oncogene, GTPase
Dog	NRAS proto-oncogene, GTPase

Publication Statistics

PubMed Score 1155.01

PubMed score by year

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PubTator Score 1389.42

PubTator score by year

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Related Publications

Text Mined References (469)

GeneRif Annotations (390)

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PMID	Year	Title