Tchem NRAS GTPase NRas

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Nras

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Nras

Protein Summary

Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• P01111
• Q14971
• Q15104
• Q15282

Gene Name

• NRAS

Ensembl ID

• ENST00000369535
• ENSP00000358548
• ENSG00000213281

Symbol

• HRAS1
• NS6
• CMNS
• NCMS
• ALPS4
• N-ras
• NRAS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
biological term	0.98
biological process	0.97
disease perturbation	0.96
interacting protein	0.94

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.01   (req: < 5)

Gene RIFs: 390   (req: <= 3)

Antibodies: 461   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.01   (req: >= 5)

Gene RIFs: 390   (req: > 3)

Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

lonafarnib

NRASTchem Enzyme

INHIBITOR IC50 : 8.55

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL2086789

NRASTchem Enzyme

IC50 : 6.3

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		37.6
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		21.5
age at first sexual intercourse measurement	EFO_0009749	1	1	1		2.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		37.6
comparative body size at age 10, self-reported	EFO_0009819	1		21.5
age at first sexual intercourse measurement	EFO_0009749	1		2.9

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NRAS proto-oncogene, GTPase	VGNC:10029	742713
Macaque	NRAS proto-oncogene, GTPase		709089
Mouse	neuroblastoma ras oncogene	MGI:97376	18176
Rat	NRAS proto-oncogene, GTPase	RGD:3205	24605
Dog	NRAS proto-oncogene, GTPase	VGNC:43959	403872

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NRAS proto-oncogene, GTPase
Macaque	NRAS proto-oncogene, GTPase
Mouse	neuroblastoma ras oncogene
Rat	NRAS proto-oncogene, GTPase
Dog	NRAS proto-oncogene, GTPase

Protein Structure (3 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01111-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (313)

Reactome (125)

KEGG (74)

PathwayCommons (53)

WikiPathways (61)

Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated NTRK2 signals through FRS2 and FRS3	11 targets	R-HSA-9028731
Reactome	Activated NTRK2 signals through RAS	9 targets	R-HSA-9026519
Reactome	Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Activation of RAS in B cells	5 targets	R-HSA-1169092

Name	Explore in Pharos	Explore in Source
Activated NTRK2 signals through FRS2 and FRS3	11 targets	R-HSA-9028731
Activated NTRK2 signals through RAS	9 targets	R-HSA-9026519
Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Activation of RAS in B cells	5 targets	R-HSA-1169092

Gene Ontology Terms (14)

Functions (3)

Components (6)

Processes (5)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	MGI
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (581)

Explore Interacting Targets

1 – 10 of 581

• See Interactions on String-DB

RIN1

Tbio

Novelty:  0.02401084

p_int:  0.999946804

p_ni:  0.000053196

Score:  0.937

Data Source:  BioPlex,STRINGDB

ABHD5

Tbio

Family:  Enzyme

Novelty:  0.00806614

p_int:  0.998478773

p_ni:  0.001520998

p_wrong:  2.29e-7

Score:  0.185

Data Source:  BioPlex,STRINGDB

RGL1

Tbio

Novelty:  0.0095933

p_int:  0.992725058

p_ni:  0.007274634

p_wrong:  3.08e-7

Score:  0.92

Data Source:  BioPlex,STRINGDB

RABGGTB

Tbio

Family:  Enzyme

Novelty:  0.06786314

p_int:  0.970552236

p_ni:  0.029447763

p_wrong:  1e-9

Score:  0.282

Data Source:  BioPlex,STRINGDB

SLC39A12

Tbio

Family:  Transporter

Novelty:  0.09127395

p_int:  0.959639932

p_ni:  0.040360068

Data Source:  BioPlex

SCGB2A1

Tbio

Novelty:  0.01902973

p_int:  0.912697979

p_ni:  0.087302019

p_wrong:  1e-9

Data Source:  BioPlex

TMEM185A

Tdark

Novelty:  0.0262898

p_int:  0.905887537

p_ni:  0.094112463

Data Source:  BioPlex

ADGRE5

Tbio

Family:  GPCR

Novelty:  0.01137558

p_int:  0.900048538

p_ni:  0.099922128

p_wrong:  0.000029334

Data Source:  BioPlex

SLC4A8

Tbio

Family:  Transporter

Novelty:  0.01606111

p_int:  0.898060166

p_ni:  0.082289085

p_wrong:  0.019650749

Data Source:  BioPlex

RTN1

Tbio

Novelty:  0.01828064

p_int:  0.875353253

p_ni:  0.124605601

p_wrong:  0.000041145

Score:  0.2

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  1155.01

PubMed score by year

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PubTator Score  1389.42

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cell membrane
Complete proteome
Disease mutation
Golgi apparatus
GTP-binding
Lipoprotein
Membrane
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
body height
comparative body size at age 10, self-reported

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
craniofacial phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
limbs/digits/tail phenotype