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Tbio
MYC
Myc proto-oncogene protein

Protein Summary
Description
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377970
  • ENSP00000367207
  • ENSG00000136997
  • ENST00000613283
  • ENSP00000479618

Symbol
  • BHLHE39
  • MRTL
  • MYCC
  • c-Myc
  • bHLHe39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
gene perturbation
1
hub protein
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16960.13   (req: < 5)
Gene RIFs: 1612   (req: <= 3)
Antibodies: 3768   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16960.13   (req: >= 5)
Gene RIFs: 1612   (req: > 3)
Antibodies: 3768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
2
2
0
1
82.2
2
2
0
1
82.2
4
1
0
1
26.6
childhood onset asthma
2
1
0
1.1
16.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
0
1
82.2
0
1
82.2
0
1
26.6
childhood onset asthma
0
1.1
16.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYC proto-oncogene, bHLH transcription factor
464393
Macaque
MYC proto-oncogene, bHLH transcription factor
694626
Mouse
MGI:97250
17869
Rat
RGD:3130
24577
Dog
MYC proto-oncogene, bHLH transcription factor
VGNC:43527
403924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYC proto-oncogene, bHLH transcription factor
Macaque
MYC proto-oncogene, bHLH transcription factor
Mouse
Rat
Dog
MYC proto-oncogene, bHLH transcription factor
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (176)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (62)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Protein-Protein Interactions (1299)
1 – 10 of 1299
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.999999997
p_ni: 3e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
FOXR2
Tbio
Family: TF
Novelty: 0.06548862
p_int: 0.999999833
p_ni: 5.4e-8
p_wrong: 1.13e-7
Score: 0.859
Data Source: BioPlex,STRINGDB
FOXR1
Tbio
Family: TF
Novelty: 0.20300395
p_int: 0.999999269
p_ni: 7.3e-7
p_wrong: 1e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
p_int: 0.999878981
p_ni: 0.000087873
p_wrong: 0.000033147
Score: 0.758
Data Source: BioPlex,STRINGDB
SUPT3H
Tbio
Novelty: 0.13202683
Score: 0.999
Data Source: STRINGDB
KAT2A
Tbio
Family: Epigenetic
Novelty: 0.00238831
Score: 0.999
Data Source: STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
Score: 0.996
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.994
Data Source: STRINGDB
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.00014147
Score: 0.993
Data Source: STRINGDB
CDKN2A
Tbio
Novelty: 0.00014147
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  16960.13

PubMed score by year
PubTator Score  7865.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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