MYC
Myc proto-oncogene protein
Protein Classes
Protein Summary
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two i ...more
- ENST00000377970
- ENSP00000367207
- ENSG00000136997
- ENST00000613283
- ENSP00000479618
- BHLHE39
- MRTL
- MYCC
- c-Myc
- bHLHe39
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
hub protein | 1 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16960.13 (req: < 5)
Gene RIFs: 1612 (req: <= 3)
Antibodies: 3768 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16960.13 (req: >= 5)
Gene RIFs: 1612 (req: > 3)
Antibodies: 3768 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
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1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Eczema | 2 | 2 | 0 | 1 | 82.2 | ||||
2 | 2 | 0 | 1 | 82.2 | |||||
4 | 1 | 0 | 1 | 26.6 | |||||
childhood onset asthma | 2 | 1 | 0 | 1.1 | 16.1 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Eczema | 0 | 1 | 82.2 | ||||
0 | 1 | 82.2 | |||||
0 | 1 | 26.6 | |||||
childhood onset asthma | 0 | 1.1 | 16.1 | ||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MYC proto-oncogene, bHLH transcription factor | 464393 | ||||||
Macaque | MYC proto-oncogene, bHLH transcription factor | 694626 | ||||||
Mouse | MGI:97250 | 17869 | ||||||
Rat | RGD:3130 | 24577 | ||||||
Dog | MYC proto-oncogene, bHLH transcription factor | VGNC:43527 | 403924 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MYC proto-oncogene, bHLH transcription factor | |||||
Macaque | MYC proto-oncogene, bHLH transcription factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | MYC proto-oncogene, bHLH transcription factor | |||||
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (176)
Reactome (56)
KEGG (32)
PathwayCommons (29)
WikiPathways (59)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 56
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Binding of TCF/LEF:CTNNB1 to target gene promoters | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Binding of TCF/LEF:CTNNB1 to target gene promoters | ||||
Ca2+ pathway | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Gene Ontology Terms (62)
Functions (12)
Components (5)
Processes (45)
Items per page:
10
1 – 10 of 12
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Protein-Protein Interactions (1299)
1 – 10 of 1299
MAX
Family: TF
Novelty: 0.00799068
p_int: 0.999999997
p_ni: 3e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
FOXR2
Family: TF
Novelty: 0.06548862
p_int: 0.999999833
p_ni: 5.4e-8
p_wrong: 1.13e-7
Score: 0.859
Data Source: BioPlex,STRINGDB
FOXR1
Family: TF
Novelty: 0.20300395
p_int: 0.999999269
p_ni: 7.3e-7
p_wrong: 1e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
YEATS4
Novelty: 0.02632024
p_int: 0.999878981
p_ni: 0.000087873
p_wrong: 0.000033147
Score: 0.758
Data Source: BioPlex,STRINGDB
SUPT3H
Novelty: 0.13202683
Score: 0.999
Data Source: STRINGDB
KAT2A
Family: Epigenetic
Novelty: 0.00238831
Score: 0.999
Data Source: STRINGDB
CDKN1A
Family: Enzyme
Novelty: 0.00033009
Score: 0.996
Data Source: STRINGDB
MED1
Family: Enzyme
Novelty: 0.00852082
Score: 0.994
Data Source: STRINGDB
CDKN2A
Family: Enzyme
Novelty: 0.00014147
Score: 0.993
Data Source: STRINGDB
CDKN2A
Novelty: 0.00014147
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score 16960.13
PubMed score by year
PubTator Score 7865.09
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword