Tbio FOS Proto-oncogene c-Fos

Protein Summary

Description

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01100
• A8K4E2
• B4DQ65
• P18849

Gene Name

• FOS

Ensembl ID

• ENST00000303562
• ENSP00000306245
• ENSG00000170345
• ENST00000535987
• ENSP00000442268
• ENST00000555686
• ENSP00000452590

Symbol

• G0S7
• p55
• AP-1
• C-FOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
gene perturbation	1
hub protein	1
virus perturbation	1

Protein Classes

PANTHER Classes

Protein / ... / Basic Leucine Zipper Transcription Factor / Proto-oncogene C-fos

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Proto-oncogene C-fos

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18173.45   (req: < 5)

Gene RIFs: 276   (req: <= 3)

Antibodies: 1561   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18173.45   (req: >= 5)

Gene RIFs: 276   (req: > 3)

Antibodies: 1561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0