Tbio FOS Proto-oncogene c-Fos

Protein Classes

PANTHER Classes

Protein / ... / Basic Leucine Zipper Transcription Factor / Proto-oncogene C-fos

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Proto-oncogene C-fos

Protein Summary

Description

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01100
• A8K4E2
• B4DQ65
• P18849

Gene Name

• FOS

Ensembl ID

• ENST00000303562
• ENSP00000306245
• ENSG00000170345
• ENST00000535987
• ENSP00000442268
• ENST00000555686
• ENSP00000452590

Symbol

• G0S7
• p55
• AP-1
• C-FOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
gene perturbation	1
hub protein	1
virus perturbation	1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13981.79   (req: < 5)

Gene RIFs: 226   (req: <= 3)

Antibodies: 1561   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13981.79   (req: >= 5)

Gene RIFs: 226   (req: > 3)

Antibodies: 1561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (223)

Reactome (43)

KEGG (38)

PathwayCommons (52)

WikiPathways (90)

Activation of the AP-1 family of transcription factors (R-HSA-450341)

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Items per page:

5

1 – 5 of 43

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the AP-1 family of transcription factors	10 targets	R-HSA-450341
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Name	Explore in Pharos	Explore in Source
Activation of the AP-1 family of transcription factors	10 targets	R-HSA-450341
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Gene Ontology Terms (54)

Functions (11)

Components (8)

Processes (35)

Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	BHF-UCL
protein heterodimerization activity	Inferred from Direct Assay (IDA)	CAFA
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
R-SMAD binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA polymerase II activating transcription factor binding	Inferred from Physical Interaction (IPI)	CAFA
transcription factor binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
RNA polymerase II core promoter sequence-specific DNA binding	Inferred from Mutant Phenotype (IMP)	CAFA
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (690)

Explore Interacting Targets

1 – 10 of 690

• See Interactions on String-DB

JUNB

Tbio

Family: TF

Novelty: 0.01119828

p_int: 0.99999998

p_ni: 1.8e-8

p_wrong: 1e-9

Score: 0.999

Data Source: BioPlex,STRINGDB

ATF2

Tbio

Family: TF

Novelty: 0.00562547

p_int: 0.999999465

p_ni: 5.35e-7

Score: 0.986

Data Source: BioPlex,STRINGDB

ATF7

Tbio

Family: TF

Novelty: 0.01433182

p_int: 0.999999462

p_ni: 5.38e-7

Score: 0.891

Data Source: BioPlex,STRINGDB

JUND

Tbio

Family: TF

Novelty: 0.00337776

p_int: 0.999999156

p_ni: 8.44e-7

Score: 0.999

Data Source: BioPlex,STRINGDB

CREB5

Tbio

Family: TF

Novelty: 0.09663345

p_int: 0.999997489

p_ni: 0.000002506

p_wrong: 5e-9

Score: 0.896

Data Source: BioPlex,STRINGDB

JUN

Tchem

Family: TF

Novelty: 0.00013623

p_int: 0.9999958

p_ni: 0.0000042

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

STK40

Tbio

Family: Kinase

Novelty: 0.12287289

p_int: 0.999988466

p_ni: 0.000011534

Score: 0.827

Data Source: BioPlex,STRINGDB

DET1

Tbio

Novelty: 0.01807423

p_int: 0.999959433

p_ni: 0.000040564

p_wrong: 3e-9

Score: 0.873

Data Source: BioPlex,STRINGDB

COP1

Tbio

Family: Enzyme

Novelty: 0.28704864

p_int: 0.998406822

p_ni: 0.001593113

p_wrong: 6.5e-8

Score: 0.738

Data Source: BioPlex,STRINGDB

VARS

Tchem

Family: Enzyme

Novelty: 0.00662364

p_int: 0.894856956

p_ni: 0.105143044

Score: 0.303

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  13981.79

PubMed score by year

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PubTator Score  4007.16

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTS

1-70

PDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKR

70-140

RIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDL

140-210

GFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRP

210-280

SGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADS

280-350

FPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

350-380

MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Endoplasmic reticulum
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene