Protein Summary
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS ...more
- ENST00000303562
- ENSP00000306245
- ENSG00000170345
- ENST00000535987
- ENSP00000442268
- ENST00000555686
- ENSP00000452590
- G0S7
- p55
- AP-1
- C-FOS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
hub protein | 1 | ||
virus perturbation | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16640.99 (req: < 5)
Gene RIFs: 226 (req: <= 3)
Antibodies: 1561 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16640.99 (req: >= 5)
Gene RIFs: 226 (req: > 3)
Antibodies: 1561 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 46
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (690)
JUNB
Family: TF
Novelty: 0.00841656
p_int: 0.99999998
p_ni: 1.8e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ATF2
Family: TF
Novelty: 0.00457832
p_int: 0.999999465
p_ni: 5.35e-7
Score: 0.986
Data Source: BioPlex,STRINGDB
ATF7
Family: TF
Novelty: 0.01470313
p_int: 0.999999462
p_ni: 5.38e-7
Score: 0.891
Data Source: BioPlex,STRINGDB
JUND
Family: TF
Novelty: 0.00277701
p_int: 0.999999156
p_ni: 8.44e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CREB5
Family: TF
Novelty: 0.03857106
p_int: 0.999997489
p_ni: 0.000002506
p_wrong: 5e-9
Score: 0.896
Data Source: BioPlex,STRINGDB
JUN
Family: TF
Novelty: 0.00006856
p_int: 0.9999958
p_ni: 0.0000042
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
STK40
Family: Kinase
Novelty: 0.10461675
p_int: 0.999988466
p_ni: 0.000011534
Score: 0.827
Data Source: BioPlex,STRINGDB
DET1
Novelty: 0.01138079
p_int: 0.999959433
p_ni: 0.000040564
p_wrong: 3e-9
Score: 0.873
Data Source: BioPlex,STRINGDB
COP1
Family: Enzyme
Novelty: 0.10908534
p_int: 0.998406822
p_ni: 0.001593113
p_wrong: 6.5e-8
Score: 0.738
Data Source: BioPlex,STRINGDB
VARS
Family: Enzyme
Novelty: 0.00720227
p_int: 0.894856956
p_ni: 0.105143044
Score: 0.303
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (12)
Upstream (3)
Downstream (9)
1 – 3 of 3
Pathways (223)
Reactome (43)
KEGG (38)
PathwayCommons (52)
WikiPathways (90)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the AP-1 family of transcription factors | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the AP-1 family of transcription factors | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Cytokine Signaling in Immune system | ||||
Viral Interactions (0)
Gene Ontology Terms (54)
Functions (11)
Components (8)
Processes (35)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 3 | 3 | 86.2 | |||||
2 | 2 | 0 | 1.1 | 32.7 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 26.6 | |||||
basophil count | 2 | 1 | 2 | 14 | |||||
basophil percentage of leukocytes | 1 | 1 | 1 | 14 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 86.2 | |||||
0 | 1.1 | 32.7 | |||||
alkaline phosphatase measurement | 1 | 26.6 | |||||
basophil count | 2 | 14 | |||||
basophil percentage of leukocytes | 1 | 14 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:95574 | 14281 | ||||||
Rat | RGD:2626 | 314322 | ||||||
Dog | Fos proto-oncogene, AP-1 transcription factor subunit | VGNC:40940 | 490792 | |||||
Horse | Fos proto-oncogene, AP-1 transcription factor subunit | VGNC:18095 | 100051632 | |||||
Cow | Fos proto-oncogene, AP-1 transcription factor subunit | VGNC:29073 | 280795 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | Fos proto-oncogene, AP-1 transcription factor subunit | |||||
Horse | Fos proto-oncogene, AP-1 transcription factor subunit | |||||
Cow | Fos proto-oncogene, AP-1 transcription factor subunit | |||||
Publication Statistics
PubMed Score 16640.99
PubMed score by year
PubTator Score 4007.16
PubTator score by year
Related Publications
Text Mined References (343)
GeneRif Annotations (226)
Items per page:
0 of 0
PMID | Year | Title |
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