Tbio FOS Proto-oncogene c-Fos

Protein Summary

Description

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01100
• A8K4E2
• B4DQ65
• P18849

Gene Name

• FOS

Ensembl ID

• ENST00000303562
• ENSP00000306245
• ENSG00000170345
• ENST00000535987
• ENSP00000442268
• ENST00000555686
• ENSP00000452590

Symbol

• G0S7
• p55
• AP-1
• C-FOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
gene perturbation	1
hub protein	1
virus perturbation	1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16640.99   (req: < 5)

Gene RIFs: 226   (req: <= 3)

Antibodies: 1561   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16640.99   (req: >= 5)

Gene RIFs: 226   (req: > 3)

Antibodies: 1561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (690)

Explore Interacting Targets

1 – 10 of 690

• See Interactions on String-DB

JUNB

Tbio

Family:  TF

Novelty:  0.00841656

p_int:  0.99999998

p_ni:  1.8e-8

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

ATF2

Tbio

Family:  TF

Novelty:  0.00457832

p_int:  0.999999465

p_ni:  5.35e-7

Score:  0.986

Data Source:  BioPlex,STRINGDB

ATF7

Tbio

Family:  TF

Novelty:  0.01470313

p_int:  0.999999462

p_ni:  5.38e-7

Score:  0.891

Data Source:  BioPlex,STRINGDB

JUND

Tbio

Family:  TF

Novelty:  0.00277701

p_int:  0.999999156

p_ni:  8.44e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

CREB5

Tbio

Family:  TF

Novelty:  0.03857106

p_int:  0.999997489

p_ni:  0.000002506

p_wrong:  5e-9

Score:  0.896

Data Source:  BioPlex,STRINGDB

JUN

Tchem

Family:  TF

Novelty:  0.00006856

p_int:  0.9999958

p_ni:  0.0000042

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

STK40

Tbio

Family:  Kinase

Novelty:  0.10461675

p_int:  0.999988466

p_ni:  0.000011534

Score:  0.827

Data Source:  BioPlex,STRINGDB

DET1

Tbio

Novelty:  0.01138079

p_int:  0.999959433

p_ni:  0.000040564

p_wrong:  3e-9

Score:  0.873

Data Source:  BioPlex,STRINGDB

COP1

Tbio

Family:  Enzyme

Novelty:  0.10908534

p_int:  0.998406822

p_ni:  0.001593113

p_wrong:  6.5e-8

Score:  0.738

Data Source:  BioPlex,STRINGDB

VARS

Tchem

Family:  Enzyme

Novelty:  0.00720227

p_int:  0.894856956

p_ni:  0.105143044

Score:  0.303

Data Source:  BioPlex,STRINGDB

Pathways (223)

Reactome (43)

KEGG (38)

PathwayCommons (52)

WikiPathways (90)

Activation of the AP-1 family of transcription factors (R-HSA-450341)

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5

1 – 5 of 43

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the AP-1 family of transcription factors	10 targets	R-HSA-450341
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Name	Explore in Pharos	Explore in Source
Activation of the AP-1 family of transcription factors	10 targets	R-HSA-450341
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Gene Ontology Terms (54)

Functions (11)

Components (8)

Processes (35)

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10

1 – 10 of 11

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	BHF-UCL
protein heterodimerization activity	Inferred from Direct Assay (IDA)	CAFA
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
R-SMAD binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA polymerase II activating transcription factor binding	Inferred from Physical Interaction (IPI)	CAFA
transcription factor binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
RNA polymerase II core promoter sequence-specific DNA binding	Inferred from Mutant Phenotype (IMP)	CAFA
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl

GWAS Traits (7)

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1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	3	3		86.2
inflammatory bowel disease	EFO_0003767	2	2	0	1.1	32.7
alkaline phosphatase measurement	EFO_0004533	1	1	1		26.6
basophil count	EFO_0005090	2	1	2		14
basophil percentage of leukocytes	EFO_0007992	1	1	1		14

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3		86.2
inflammatory bowel disease	EFO_0003767	0	1.1	32.7
alkaline phosphatase measurement	EFO_0004533	1		26.6
basophil count	EFO_0005090	2		14
basophil percentage of leukocytes	EFO_0007992	1		14

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Endoplasmic reticulum
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
basophil count
basophil percentage of leukocytes
Crohn's disease
heel bone mineral density
inflammatory bowel disease
monocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	FBJ osteosarcoma oncogene	MGI:95574	14281
Rat	Fos proto-oncogene, AP-1 transcription factor subunit	RGD:2626	314322
Dog	Fos proto-oncogene, AP-1 transcription factor subunit	VGNC:40940	490792
Horse	Fos proto-oncogene, AP-1 transcription factor subunit	VGNC:18095	100051632
Cow	Fos proto-oncogene, AP-1 transcription factor subunit	VGNC:29073	280795

Species	Name	OMA	EggNOG	Inparanoid
Mouse	FBJ osteosarcoma oncogene
Rat	Fos proto-oncogene, AP-1 transcription factor subunit
Dog	Fos proto-oncogene, AP-1 transcription factor subunit
Horse	Fos proto-oncogene, AP-1 transcription factor subunit
Cow	Fos proto-oncogene, AP-1 transcription factor subunit

Publication Statistics

PubMed Score 16640.99

PubMed score by year

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PubTator Score 4007.16

PubTator score by year

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