Tbio KNG1 Kininogen-1

Protein Summary

Description

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P01042
• A8K474
• B2RCR2
• C9JEX1
• P01043
• Q53EQ0
• Q6PAU9
• Q7M4P1

Gene Name

• KNG1

Ensembl ID

• ENST00000265023
• ENSP00000265023
• ENSG00000113889
• ENST00000287611
• ENSP00000287611
• ENST00000447445
• ENSP00000396025
• ENST00000644859
• ENSP00000493985
• ENST00000645909
• ENSP00000496167

Symbol

• BDK
• KNG
• BK
• BDK
• KNG
• HMWK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
chemical	0.83
virus perturbation	0.83
co-expressed gene	0.76
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Kininogen-1

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Kininogen-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13097.01   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 673   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13097.01   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 673   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0