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Tbio
KNG1
Kininogen-1

Protein Summary
Description
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265023
  • ENSP00000265023
  • ENSG00000113889
  • ENST00000287611
  • ENSP00000287611
  • ENST00000447445
  • ENSP00000396025
  • ENST00000644859
  • ENSP00000493985
  • ENST00000645909
  • ENSP00000496167

Symbol
  • BDK
  • KNG
  • BK
  • BDK
  • KNG
  • HMWK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
chemical
0.83
virus perturbation
0.83
co-expressed gene
0.76
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13097.01   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 673   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13097.01   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 673   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0