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Tbio
KNG1
Kininogen-1

Protein Summary
Description
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265023
  • ENSP00000265023
  • ENSG00000113889
  • ENST00000287611
  • ENSP00000287611
  • ENST00000447445
  • ENSP00000396025
  • ENST00000644859
  • ENSP00000493985
  • ENST00000645909
  • ENSP00000496167

Symbol
  • BDK
  • KNG
  • BK
  • BDK
  • KNG
  • HMWK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
chemical
0.83
virus perturbation
0.83
co-expressed gene
0.76
molecular function
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12644.01   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 673   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12644.01   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 673   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
4
5
5
96.5
partial thromboplastin time
2
3
3
95.7
glomerular filtration rate
7
5
6
8.1
92
factor XI measurement
1
1
1
88.4
BMI-adjusted adiponectin measurement
1
2
2
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
5
96.5
partial thromboplastin time
3
95.7
glomerular filtration rate
6
8.1
92
factor XI measurement
1
88.4
BMI-adjusted adiponectin measurement
2
85.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kininogen 1
VGNC:1858
460916
Macaque
kininogen 1
707466
Mouse
MGI:3027157
385643
Dog
kininogen 1
VGNC:53466
478666
Horse
kininogen 1
VGNC:19498
100068133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kininogen 1
Macaque
kininogen 1
Mouse
Dog
kininogen 1
Horse
kininogen 1
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01042-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (82)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Formation of Fibrin Clot (Clotting Cascade)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
Protein-Protein Interactions (698)
1 – 10 of 698
CTSO
Tbio
Family:  Enzyme
Novelty:  0.09963965
p_int:  0.999990261
p_ni:  0.000009734
p_wrong:  5e-9
Score:  0.206
Data Source:  BioPlex,STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999435407
p_ni:  0.000564271
p_wrong:  3.22e-7
Data Source:  BioPlex
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.999234184
p_ni:  0.000765816
Score:  0.509
Data Source:  BioPlex,STRINGDB
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
p_int:  0.998921108
p_ni:  0.001078892
Score:  0.183
Data Source:  BioPlex,STRINGDB
P3H3
Tbio
Family:  Enzyme
Novelty:  0.0010004
p_int:  0.994106249
p_ni:  0.005893751
Score:  0.17
Data Source:  BioPlex,STRINGDB
CTSV
Tchem
Family:  Enzyme
Novelty:  0.00916301
p_int:  0.989946728
p_ni:  0.010053272
Score:  0.564
Data Source:  BioPlex,STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.985073491
p_ni:  0.014926243
p_wrong:  2.66e-7
Data Source:  BioPlex
PPP2R2C
Tbio
Family:  Enzyme
Novelty:  0.05453128
p_int:  0.985011144
p_ni:  0.002364233
p_wrong:  0.012624623
Data Source:  BioPlex
ZNF562
Tdark
Family:  TF
Novelty:  12.38372093
p_int:  0.977562749
p_ni:  0.022434957
p_wrong:  0.000002293
Score:  0.161
Data Source:  BioPlex,STRINGDB
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.962820952
p_ni:  0.037179048
Data Source:  BioPlex
Publication Statistics
PubMed Score  12644.01

PubMed score by year
PubTator Score  4971.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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