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Tchem
KNG1
Kininogen-1

Protein Summary
Description
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265023
  • ENSP00000265023
  • ENSG00000113889
  • ENST00000287611
  • ENSP00000287611
  • ENST00000447445
  • ENSP00000396025
  • ENST00000644859
  • ENSP00000493985
  • ENST00000645909
  • ENSP00000496167

Symbol
  • BDK
  • KNG
  • BK
  • BDK
  • KNG
  • HMWK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
chemical
0.83
virus perturbation
0.83
co-expressed gene
0.76
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12588.63   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 673   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12588.63   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 673   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 59
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
partial thromboplastin time
2
2
2
97.2
factor XI measurement
1
1
1
96.7
TNF-related apoptosis-inducing ligand measurement
1
1
1
78.8
vascular endothelial growth factor D measurement
1
1
1
70.3
blood metabolite measurement
1
1
1
52.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
partial thromboplastin time
2
97.2
factor XI measurement
1
96.7
TNF-related apoptosis-inducing ligand measurement
1
78.8
vascular endothelial growth factor D measurement
1
70.3
blood metabolite measurement
1
52.8
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (82)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Formation of Fibrin Clot (Clotting Cascade)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
Protein-Protein Interactions (698)
1 – 10 of 698
CTSO
Tbio
Family: Enzyme
Novelty: 0.09963965
p_int: 0.999990261
p_ni: 0.000009734
p_wrong: 5e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999435407
p_ni: 0.000564271
p_wrong: 3.22e-7
Data Source: BioPlex
CAPN1
Tchem
Novelty: 0.00252811
p_int: 0.999234184
p_ni: 0.000765816
Score: 0.509
Data Source: BioPlex,STRINGDB
ANAPC1
Tbio
Family: Enzyme
Novelty: 0.0521845
p_int: 0.998921108
p_ni: 0.001078892
Score: 0.183
Data Source: BioPlex,STRINGDB
P3H3
Tbio
Family: Enzyme
Novelty: 0.0010004
p_int: 0.994106249
p_ni: 0.005893751
Score: 0.17
Data Source: BioPlex,STRINGDB
CTSV
Tchem
Family: Enzyme
Novelty: 0.00916301
p_int: 0.989946728
p_ni: 0.010053272
Score: 0.564
Data Source: BioPlex,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
p_int: 0.985073491
p_ni: 0.014926243
p_wrong: 2.66e-7
Data Source: BioPlex
PPP2R2C
Tbio
Family: Enzyme
Novelty: 0.05453128
p_int: 0.985011144
p_ni: 0.002364233
p_wrong: 0.012624623
Data Source: BioPlex
ZNF562
Tdark
Family: TF
Novelty: 12.38372093
p_int: 0.977562749
p_ni: 0.022434957
p_wrong: 0.000002293
Score: 0.161
Data Source: BioPlex,STRINGDB
ANAPC5
Tbio
Family: Enzyme
Novelty: 0.02102572
p_int: 0.962820952
p_ni: 0.037179048
Data Source: BioPlex
Publication Statistics
PubMed Score  12588.63

PubMed score by year
PubTator Score  4971.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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