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Tbio
CSTA
Cystatin-A

Protein Summary
Description
This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264474
  • ENSP00000264474
  • ENSG00000121552

Symbol
  • STF1
  • STFA
  • AREI
  • PSS4
  • STF1
  • STFA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
gene perturbation
0.98
virus perturbation
0.92
interacting protein
0.86
small molecule perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.36   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 454   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.36   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
4
13
13
99.2
eosinophil count
2
2
2
71.4
eosinophil percentage of leukocytes
1
1
1
64.4
mean corpuscular volume
1
1
1
59.6
4
3
2
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
13
99.2
eosinophil count
2
71.4
eosinophil percentage of leukocytes
1
64.4
mean corpuscular volume
1
59.6
2
1
53.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin A
VGNC:6196
746075
Macaque
cystatin A
714547
Mouse
MGI:106198
20861
Mouse
MGI:3644688
408196
Rat
RGD:2323715
100362978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin A
Macaque
cystatin A
Mouse
Mouse
Rat
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01040-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (105)
1 – 10 of 105
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
p_int:  0.999995747
p_ni:  0.000004253
Score:  0.776
Data Source:  BioPlex,STRINGDB
CTSL
Tclin
Family:  Enzyme
Novelty:  0.00058727
p_int:  0.999940537
p_ni:  0.00005939
p_wrong:  7.3e-8
Score:  0.952
Data Source:  BioPlex,STRINGDB
CTSF
Tchem
Family:  Enzyme
Novelty:  0.01359417
p_int:  0.999485556
p_ni:  0.000501783
p_wrong:  0.000012662
Score:  0.403
Data Source:  BioPlex,STRINGDB
CTSO
Tbio
Family:  Enzyme
Novelty:  0.09963965
p_int:  0.998751014
p_ni:  0.000004231
p_wrong:  0.001244755
Score:  0.302
Data Source:  BioPlex,STRINGDB
TGFBRAP1
Tbio
Novelty:  0.05996919
p_int:  0.996238142
p_ni:  0.003761833
p_wrong:  2.5e-8
Data Source:  BioPlex
CTSC
Tchem
Family:  Enzyme
Novelty:  0.00119917
p_int:  0.993962125
p_ni:  0.006037875
Score:  0.376
Data Source:  BioPlex,STRINGDB
CTSV
Tchem
Family:  Enzyme
Novelty:  0.00916301
p_int:  0.993916843
p_ni:  0.005965065
p_wrong:  0.000118092
Score:  0.861
Data Source:  BioPlex,STRINGDB
CTSB
Tchem
Family:  Enzyme
Novelty:  0.00026238
p_int:  0.969600772
p_ni:  0.030399228
Score:  0.977
Data Source:  BioPlex,STRINGDB
VPS11
Tbio
Novelty:  0.00496411
p_int:  0.963289208
p_ni:  0.03671079
p_wrong:  1e-9
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.799875895
p_ni:  0.200124105
Score:  0.211
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  227.36

PubMed score by year
PubTator Score  137.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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