Tbio CSTA Cystatin-A

Protein Summary

Description

This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01040
• Q6IB90

Gene Name

• CSTA

Ensembl ID

• ENST00000264474
• ENSP00000264474
• ENSG00000121552

Symbol

• STF1
• STFA
• AREI
• PSS4
• STF1
• STFA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
gene perturbation	0.98
virus perturbation	0.92
interacting protein	0.86
small molecule perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Cysteine Protease Inhibitor / Cystatin-a

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Cysteine Protease Inhibitor / Cystatin-a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.36   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 454   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.36   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0