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Tbio
CST4
Cystatin-S

Protein Summary
Description
This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and semina ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217423
  • ENSP00000217423
  • ENSG00000101441
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
cell line
0.66
gene perturbation
0.53
interacting protein
0.46
disease
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (81)
1 – 10 of 81
CST1
Tbio
Novelty: 0.02399609
p_int: 0.999999322
p_ni: 4.6e-8
p_wrong: 6.32e-7
Score: 0.883
Data Source: BioPlex,STRINGDB
PRKCE
Tchem
Family: Kinase
Novelty: 0.00890161
p_int: 0.99947447
p_ni: 0.000525528
p_wrong: 2e-9
Data Source: BioPlex
HINT2
Tbio
Novelty: 0.09560851
p_int: 0.998726921
p_ni: 0.001273063
p_wrong: 1.6e-8
Data Source: BioPlex
GTF2B
Tbio
Novelty: 0.00179492
p_int: 0.997693703
p_ni: 0.002301692
p_wrong: 0.000004605
Data Source: BioPlex
RHOBTB1
Tbio
Novelty: 0.02152609
p_int: 0.996585391
p_ni: 0.003414528
p_wrong: 8.1e-8
Data Source: BioPlex
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.996470585
p_ni: 0.003148816
p_wrong: 0.000380599
Data Source: BioPlex
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.995732113
p_ni: 0.004267833
p_wrong: 5.4e-8
Data Source: BioPlex
KCNG4
Tclin
Family: IC
Novelty: 0.07920772
p_int: 0.995570873
p_ni: 0.00442905
p_wrong: 7.7e-8
Score: 0.795
Data Source: BioPlex,STRINGDB
ZNF491
Tdark
Family: TF
Novelty: 4.75862069
p_int: 0.994953011
p_ni: 0.005046962
p_wrong: 2.8e-8
Data Source: BioPlex
TNFRSF19
Tbio
Novelty: 0.01295599
p_int: 0.994060075
p_ni: 0.005905906
p_wrong: 0.000034019
Data Source: BioPlex
Publication Statistics
PubMed Score  107.29

PubMed score by year
PubTator Score  36.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer