Tbio CST3 Cystatin-C

Protein Summary

Description

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P01034
• B2R5J9
• D3DW42
• Q6FGW9

Gene Name

• CST3

Ensembl ID

• ENST00000376925
• ENSP00000366124
• ENSG00000101439
• ENST00000398409
• ENSP00000381446
• ENST00000398411
• ENSP00000381448

Symbol

• ARMD11
• HEL-S-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
PubMedID	0.98
disease perturbation	0.9
kinase perturbation	0.88
gene perturbation	0.78

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3600.66   (req: < 5)

Gene RIFs: 430   (req: <= 3)

Antibodies: 1243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3600.66   (req: >= 5)

Gene RIFs: 430   (req: > 3)

Antibodies: 1243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (9)

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (69)

Reactome (8)

KEGG (1)

WikiPathways (60)

Amyloid fiber formation (R-HSA-977225)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Amyloid fiber formation	79 targets	R-HSA-977225
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metabolism of proteins	2050 targets	R-HSA-392499
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (23)

Functions (5)

Components (6)

Processes (12)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
cysteine-type endopeptidase inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
endopeptidase inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
amyloid-beta binding	Inferred from Physical Interaction (IPI)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protease binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Protein-Protein Interactions (235)

Explore Interacting Targets

1 – 10 of 235

• See Interactions on String-DB

DDX31

Tbio

Family: Enzyme

Novelty: 4

p_int: 0.950121091

p_ni: 0.049878896

p_wrong: 1.2e-8

Score: 0.189

Data Source: BioPlex,STRINGDB

CSTB

Tbio

Novelty: 0.00153055

Score: 0.979

Data Source: STRINGDB

ALB

Tchem

Novelty: 0.0000092

Score: 0.978

Data Source: STRINGDB

B2M

Tbio

Novelty: 0.00012184

Score: 0.973

Data Source: STRINGDB

CTSD

Tchem

Family: Enzyme

Novelty: 0.0003299

Score: 0.972

Data Source: STRINGDB

CTSS

Tchem

Family: Enzyme

Novelty: 0.00788672

Score: 0.96

Data Source: STRINGDB

APOE

Tbio

Novelty: 0.0000621

Score: 0.959

Data Source: STRINGDB

IL6

Tclin

Novelty: 0.00002829

Score: 0.956

Data Source: STRINGDB

APP

Tchem

Novelty: 0.00011446

Score: 0.956

Data Source: STRINGDB

FGF23

Tclin

Novelty: 0.00057077

Score: 0.955

Data Source: STRINGDB

Publication Statistics

PubMed Score  3600.66

PubMed score by year

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PubTator Score  3557.03

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHS

1-70

RALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSK

70-140

STCQDA

140-146

MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA

Find similar targets by:

Uniprot Keyword

3D-structure
Age-related macular degeneration
Amyloid
Amyloidosis
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Phosphoprotein