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Tbio
CST3
Cystatin-C

Protein Summary
Description
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376925
  • ENSP00000366124
  • ENSG00000101439
  • ENST00000398409
  • ENSP00000381446
  • ENST00000398411
  • ENSP00000381448

Symbol
  • ARMD11
  • HEL-S-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
PubMedID
0.98
disease perturbation
0.9
kinase perturbation
0.88
gene perturbation
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4624.48   (req: < 5)
Gene RIFs: 430   (req: <= 3)
Antibodies: 1243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4624.48   (req: >= 5)
Gene RIFs: 430   (req: > 3)
Antibodies: 1243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
acute coronary syndrome
1
1
1
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
acute coronary syndrome
1
88.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102519
13010
Rat
RGD:2432
25307
Dog
cystatin-C-like
607874
Horse
cystatin C [Source:HGNC Symbol;Acc:HGNC:2475]
Cow
cystatin C
281102
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cystatin-C-like
Horse
cystatin C [Source:HGNC Symbol;Acc:HGNC:2475]
Cow
cystatin C
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01034-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (69)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (235)
1 – 10 of 235
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.950121091
p_ni: 0.049878896
p_wrong: 1.2e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
CSTB
Tbio
Novelty: 0.00311198
Score: 0.979
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.978
Data Source: STRINGDB
B2M
Tbio
Novelty: 0.00011248
Score: 0.973
Data Source: STRINGDB
CTSD
Tchem
Family: Enzyme
Novelty: 0.00029823
Score: 0.972
Data Source: STRINGDB
CTSS
Tchem
Family: Enzyme
Novelty: 0.00786042
Score: 0.96
Data Source: STRINGDB
APOE
Tbio
Novelty: 0.00005049
Score: 0.959
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.956
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.956
Data Source: STRINGDB
CTSH
Tchem
Family: Enzyme
Novelty: 0.00336694
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  4624.48

PubMed score by year
PubTator Score  3557.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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