Protein Summary
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virt ...more
- ENST00000376925
- ENSP00000366124
- ENSG00000101439
- ENST00000398409
- ENSP00000381446
- ENST00000398411
- ENSP00000381448
- ARMD11
- HEL-S-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
PubMedID | 0.98 | ||
disease perturbation | 0.9 | ||
kinase perturbation | 0.88 | ||
gene perturbation | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4797.07 (req: < 5)
Gene RIFs: 430 (req: <= 3)
Antibodies: 1243 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4797.07 (req: >= 5)
Gene RIFs: 430 (req: > 3)
Antibodies: 1243 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (235)
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.950121091
p_ni: 0.049878896
p_wrong: 1.2e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (69)
Reactome (8)
KEGG (1)
WikiPathways (60)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (5)
Components (6)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 1 | 77.9 | ||||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 77.9 | ||||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:102519 | 13010 | ||||||
Rat | RGD:2432 | 25307 | ||||||
Dog | cystatin-C-like | 607874 | ||||||
Horse | cystatin C [Source:HGNC Symbol;Acc:HGNC:2475] | |||||||
Cow | cystatin C | 281102 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | cystatin-C-like | |||||
Horse | cystatin C [Source:HGNC Symbol;Acc:HGNC:2475] | |||||
Cow | cystatin C | |||||
Publication Statistics
PubMed Score 4797.07
PubMed score by year
PubTator Score 3557.03
PubTator score by year
Related Publications
Text Mined References (486)
GeneRif Annotations (430)
Items per page:
0 of 0
PMID | Year | Title |
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