Protein Summary
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virt ...more
- ENST00000376925
- ENSP00000366124
- ENSG00000101439
- ENST00000398409
- ENSP00000381446
- ENST00000398411
- ENSP00000381448
- ARMD11
- HEL-S-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
PubMedID | 0.98 | ||
disease perturbation | 0.9 | ||
kinase perturbation | 0.88 | ||
gene perturbation | 0.78 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4624.48 (req: < 5)
Gene RIFs: 430 (req: <= 3)
Antibodies: 1243 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4624.48 (req: >= 5)
Gene RIFs: 430 (req: > 3)
Antibodies: 1243 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
acute coronary syndrome | 1 | 1 | 1 | 88.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
acute coronary syndrome | 1 | 88.2 | |||||
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:102519 | 13010 | ||||||
Rat | RGD:2432 | 25307 | ||||||
Dog | cystatin-C-like | 607874 | ||||||
Horse | cystatin C [Source:HGNC Symbol;Acc:HGNC:2475] | |||||||
Cow | cystatin C | 281102 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | cystatin-C-like | |||||
Horse | cystatin C [Source:HGNC Symbol;Acc:HGNC:2475] | |||||
Cow | cystatin C | |||||
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (69)
Reactome (8)
KEGG (1)
WikiPathways (60)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
Neutrophil degranulation | ||||
Gene Ontology Terms (23)
Functions (5)
Components (6)
Processes (12)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (235)
1 – 10 of 235
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.950121091
p_ni: 0.049878896
p_wrong: 1.2e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
CSTB
Novelty: 0.00311198
Score: 0.979
Data Source: STRINGDB
ALB
Novelty: 0.00000616
Score: 0.978
Data Source: STRINGDB
B2M
Novelty: 0.00011248
Score: 0.973
Data Source: STRINGDB
CTSD
Family: Enzyme
Novelty: 0.00029823
Score: 0.972
Data Source: STRINGDB
CTSS
Family: Enzyme
Novelty: 0.00786042
Score: 0.96
Data Source: STRINGDB
APOE
Novelty: 0.00005049
Score: 0.959
Data Source: STRINGDB
IL6
Novelty: 0.00001819
Score: 0.956
Data Source: STRINGDB
APP
Novelty: 0.00008964
Score: 0.956
Data Source: STRINGDB
CTSH
Family: Enzyme
Novelty: 0.00336694
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score 4624.48
PubMed score by year
PubTator Score 3557.03
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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