You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TIMP1
Metalloproteinase inhibitor 1

Protein Summary
Description
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218388
  • ENSP00000218388
  • ENSG00000102265

Symbol
  • CLGI
  • TIMP
  • EPA
  • EPO
  • HCI
  • CLGI
  • TIMP
  • TIMP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
kinase perturbation
0.99
chemical
0.98
phenotype
0.91
transcription factor perturbation
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4808.84   (req: < 5)
Gene RIFs: 564   (req: <= 3)
Antibodies: 1007   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4808.84   (req: >= 5)
Gene RIFs: 564   (req: > 3)
Antibodies: 1007   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TIMP metallopeptidase inhibitor 1
574348
Mouse
MGI:98752
21857
Rat
RGD:621675
116510
Dog
TIMP metallopeptidase inhibitor 1
VGNC:47376
403816
Cow
TIMP metallopeptidase inhibitor 1
VGNC:35870
282092
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TIMP metallopeptidase inhibitor 1
Mouse
Rat
Dog
TIMP metallopeptidase inhibitor 1
Cow
TIMP metallopeptidase inhibitor 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01033-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (74)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Cytokine Signaling in Immune system
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Cytokine Signaling in Immune system
Degradation of the extracellular matrix
Extracellular matrix organization
Hemostasis
Gene Ontology Terms (34)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (398)
1 – 10 of 398
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
p_int: 0.999998964
p_ni: 0.000001
p_wrong: 3.6e-8
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
MMP10
Tchem
Novelty: 0.00112113
p_int: 0.995707391
p_ni: 0.004180686
p_wrong: 0.000111922
Score: 0.957
Data Source: BioPlex,STRINGDB
IGFBP1
Tchem
Novelty: 0.0006975
p_int: 0.985022977
p_ni: 0.014728711
p_wrong: 0.000248313
Score: 0.95
Data Source: BioPlex,STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.970905138
p_ni: 0.024193598
p_wrong: 0.004901264
Score: 0.31
Data Source: BioPlex,STRINGDB
MMP1
Tchem
Family: Enzyme
Novelty: 0.00030922
Score: 0.994
Data Source: STRINGDB
MMP3
Tchem
Novelty: 0.00041675
Score: 0.989
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.982
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.98
Data Source: STRINGDB
MMP14
Tchem
Family: Enzyme
Novelty: 0.00083836
Score: 0.98
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  4808.84

PubMed score by year
PubTator Score  2856.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: