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Tclin
C5
Complement C5

Protein Summary
Description
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223642
  • ENSP00000223642
  • ENSG00000106804

Symbol
  • CPAMD4
  • C5D
  • C5a
  • C5b
  • ECLZB
  • CPAMD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
biological term
0.85
gene perturbation
0.76
disease
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.07   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 679   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.07   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 679   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
89.1
birth weight
4
3
4
77.8
5
4
2
1.1
77.7
serum non-albumin protein measurement
1
1
1
64
myeloid white cell count
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
89.1
birth weight
4
77.8
2
1.1
77.7
serum non-albumin protein measurement
1
64
myeloid white cell count
1
60.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C5
VGNC:4628
464703
Macaque
complement C5
700467
Mouse
MGI:96031
15139
Dog
complement C5
VGNC:38595
474816
Cow
complement C5
VGNC:49997
512045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C5
Macaque
complement C5
Mouse
Dog
complement C5
Cow
complement C5
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01031-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (44)
Activation of C3 and C5 (R-HSA-174577)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of C3 and C5
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Complement cascade
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation of C3 and C5
Class A/1 (Rhodopsin-like receptors)
Complement cascade
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (280)
1 – 10 of 280
C6
Tbio
Novelty:  0.0132784
Score:  0.993
Data Source:  Reactome,STRINGDB
C5AR1
Tchem
Family:  GPCR
Novelty:  0.00188281
Score:  0.987
Data Source:  Reactome,STRINGDB
C8B
Tbio
Novelty:  0.00873524
Score:  0.978
Data Source:  Reactome,STRINGDB
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
Score:  0.972
Data Source:  Reactome,STRINGDB
C7
Tbio
Novelty:  0.01540501
Score:  0.968
Data Source:  Reactome,STRINGDB
CPB2
Tchem
Family:  Enzyme
Novelty:  0.00164543
Score:  0.966
Data Source:  Reactome,STRINGDB
C8A
Tbio
Novelty:  0.00429321
Score:  0.963
Data Source:  Reactome,STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.963
Data Source:  Reactome,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.956
Data Source:  STRINGDB
C9
Tchem
Novelty:  0.00749298
Score:  0.954
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  448.07

PubMed score by year
PubTator Score  1356.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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