Protein Summary
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotei ...more
- ENST00000223642
- ENSP00000223642
- ENSG00000106804
- CPAMD4
- C5D
- C5a
- C5b
- ECLZB
- CPAMD4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
protein domain | 1 | ||
biological term | 0.85 | ||
gene perturbation | 0.76 | ||
disease | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 448.07 (req: < 5)
Gene RIFs: 145 (req: <= 3)
Antibodies: 679 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 448.07 (req: >= 5)
Gene RIFs: 145 (req: > 3)
Antibodies: 679 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (0)
Protein-Protein Interactions (280)
Nearest Tclin Targets
Pathways (44)
Reactome (13)
KEGG (7)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of C3 and C5 | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Complement cascade | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of C3 and C5 | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Complement cascade | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (4)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 2 | 3 | 89.1 | |||||
birth weight | 4 | 3 | 4 | 77.8 | |||||
5 | 4 | 2 | 1.1 | 77.7 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 64 | |||||
myeloid white cell count | 1 | 1 | 1 | 60.2 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 89.1 | |||||
birth weight | 4 | 77.8 | |||||
2 | 1.1 | 77.7 | |||||
serum non-albumin protein measurement | 1 | 64 | |||||
myeloid white cell count | 1 | 60.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | complement C5 | VGNC:4628 | 464703 | |||||
Macaque | complement C5 | 700467 | ||||||
Mouse | MGI:96031 | 15139 | ||||||
Dog | complement C5 | VGNC:38595 | 474816 | |||||
Cow | complement C5 | VGNC:49997 | 512045 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | complement C5 | |||||
Macaque | complement C5 | |||||
Mouse | ||||||
Dog | complement C5 | |||||
Cow | complement C5 | |||||
Publication Statistics
PubMed Score 448.07
PubMed score by year
PubTator Score 1356.65
PubTator score by year
Related Publications
Text Mined References (233)
GeneRif Annotations (145)
Items per page:
0 of 0
PMID | Year | Title |
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