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Tbio
C3
Complement C3

Protein Summary
Description
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245907
  • ENSP00000245907
  • ENSG00000125730

Symbol
  • CPAMD1
  • ASP
  • C3a
  • C3b
  • AHUS5
  • ARMD9
  • CPAMD1
  • HEL-S-62p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
small molecule perturbation
0.98
biological process
0.96
disease
0.9
virus perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5066.85   (req: < 5)
Gene RIFs: 401   (req: <= 3)
Antibodies: 1621   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5066.85   (req: >= 5)
Gene RIFs: 401   (req: > 3)
Antibodies: 1621   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
1.4
99.3
2
2
0
1.6
95.2
atrophic macular degeneration
2
2
0
1.8
95
complement C3 measurement
1
1
1
45.8
complement C4 measurement
1
1
1
45.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
99.3
0
1.6
95.2
atrophic macular degeneration
0
1.8
95
complement C3 measurement
1
45.8
complement C4 measurement
1
45.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C3
VGNC:2363
455644
Mouse
MGI:88227
12266
Rat
RGD:2232
24232
Dog
complement C3
VGNC:38591
476728
Horse
complement C3-like
100060539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C3
Mouse
Rat
Dog
complement C3
Horse
complement C3-like
Protein Structure (45 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01024-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 45
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (43)
Activation of C3 and C5 (R-HSA-174577)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of C3 and C5
Reactome
Adaptive Immune System
Reactome
Alternative complement activation
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Complement cascade
Name
Explore in Pharos
Explore in Source
Activation of C3 and C5
Adaptive Immune System
Alternative complement activation
Class A/1 (Rhodopsin-like receptors)
Complement cascade
Protein-Protein Interactions (566)
1 – 10 of 566
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999997541
p_ni: 0.000002459
Data Source: BioPlex
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999997176
p_ni: 0.000002823
Data Source: BioPlex
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.999994097
p_ni: 0.000005903
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999988431
p_ni: 0.000011568
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.999766821
p_ni: 0.000233174
p_wrong: 5e-9
Data Source: BioPlex
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.99940486
p_ni: 0.00059514
Data Source: BioPlex
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.997896323
p_ni: 0.002103673
p_wrong: 4e-9
Score: 0.311
Data Source: BioPlex,STRINGDB
ASCC1
Tbio
Novelty: 0.1280098
p_int: 0.993149962
p_ni: 0.006849953
p_wrong: 8.5e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.866879517
p_ni: 0.133028447
p_wrong: 0.000092036
Data Source: BioPlex
CA8
Tbio
Family: Enzyme
Novelty: 0.0041859
p_int: 0.779390978
p_ni: 0.070449224
p_wrong: 0.150159798
Score: 0.185
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5066.85

PubMed score by year
PubTator Score  4949.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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