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Tbio
A2M
Alpha-2-macroglobulin

Protein Summary
Description
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is impl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318602
  • ENSP00000323929
  • ENSG00000175899

Symbol
  • CPAMD5
  • A2MD
  • CPAMD5
  • FWP007
  • S863-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
PubMedID
0.98
small molecule perturbation
0.83
biological term
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.14   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 862   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.14   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 862   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
14.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
14.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
alpha-2-macroglobulin
716834
Mouse
MGI:2449119
232345
Rat
RGD:6492449
100911545
Cow
alpha-2-macroglobulin
513856
Pig
alpha-2-macroglobulin
403166
Species
Name
OMA
EggNOG
Inparanoid
Macaque
alpha-2-macroglobulin
Mouse
Rat
Cow
alpha-2-macroglobulin
Pig
alpha-2-macroglobulin
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01023-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
HDL assembly
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Formation of Fibrin Clot (Clotting Cascade)
HDL assembly
Hemostasis
Gene Ontology Terms (22)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
AgBase
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (216)
1 – 10 of 216
PZP
Tbio
Novelty: 0.00670076
p_int: 1
Score: 0.424
Data Source: BioPlex,STRINGDB
HAPLN3
Tdark
Novelty: 0.19545048
p_int: 0.999987194
p_ni: 0.000012798
p_wrong: 8e-9
Score: 0.24
Data Source: BioPlex,STRINGDB
CRTAC1
Tbio
Novelty: 0.09442374
p_int: 0.999920278
p_ni: 0.000079719
p_wrong: 3e-9
Score: 0.286
Data Source: BioPlex,STRINGDB
METRN
Tbio
Novelty: 0.03357541
p_int: 0.999916634
p_ni: 0.000002244
p_wrong: 0.000081122
Score: 0.221
Data Source: BioPlex,STRINGDB
PTX3
Tbio
Novelty: 0.00153752
p_int: 0.99982907
p_ni: 0.000142432
p_wrong: 0.000028498
Score: 0.215
Data Source: BioPlex,STRINGDB
PRADC1
Tdark
Family: Enzyme
Novelty: 0.15508387
p_int: 0.999320556
p_ni: 0.000409535
p_wrong: 0.000269909
Score: 0.187
Data Source: BioPlex,STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.998365126
p_ni: 0.001634874
Score: 0.221
Data Source: BioPlex,STRINGDB
LOXL1
Tbio
Family: Enzyme
Novelty: 0.00479897
p_int: 0.998001153
p_ni: 0.000001899
p_wrong: 0.001996948
Score: 0.361
Data Source: BioPlex,STRINGDB
EOGT
Tbio
Family: Enzyme
Novelty: 0.08290891
p_int: 0.984883221
p_ni: 0.007245006
p_wrong: 0.007871773
Data Source: BioPlex
GALNT12
Tbio
Family: Enzyme
Novelty: 0.085131
p_int: 0.971645423
p_ni: 0.02835457
p_wrong: 7e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  1194.14

PubMed score by year
PubTator Score  2262.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer