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Tbio
AGT
Angiotensinogen

Protein Summary
Description
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin conve ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366667
  • ENSP00000355627
  • ENSG00000135744

Symbol
  • SERPINA8
  • ANHU
  • hFLT1
  • SERPINA8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease perturbation
0.87
disease
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1855.28   (req: < 5)
Gene RIFs: 591   (req: <= 3)
Antibodies: 928   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1855.28   (req: >= 5)
Gene RIFs: 591   (req: > 3)
Antibodies: 928   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 98
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
66
1
1
1
16.8
Agents acting on the renin-angiotensin system use measurement
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
66
1
16.8
Agents acting on the renin-angiotensin system use measurement
1
13.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiotensinogen
VGNC:40
450104
Macaque
angiotensinogen
714203
Mouse
MGI:87963
11606
Rat
RGD:2069
24179
Dog
angiotensinogen
VGNC:37718
403783
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiotensinogen
Macaque
angiotensinogen
Mouse
Rat
Dog
angiotensinogen
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (51)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (103)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (585)
1 – 10 of 585
RIPK4
Tchem
Family: Kinase
Novelty: 0.00818379
p_int: 0.968270485
p_ni: 0.029067675
p_wrong: 0.002661841
Score: 0.209
Data Source: BioPlex,STRINGDB
NDUFA3
Tclin
Family: Enzyme
Novelty: 0.21111937
p_int: 0.847857514
p_ni: 0.141990399
p_wrong: 0.010152087
Score: 0.219
Data Source: BioPlex,STRINGDB
CANX
Tbio
Novelty: 0.00087002
p_int: 0.84649898
p_ni: 0.15350102
Score: 0.17
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.845725347
p_ni: 0.154274653
Score: 0.199
Data Source: BioPlex,STRINGDB
REN
Tclin
Family: Enzyme
Novelty: 0.00002435
Score: 0.999
Data Source: Reactome,STRINGDB
ACE
Tclin
Family: Enzyme
Novelty: 0.00001993
Score: 0.996
Data Source: Reactome,STRINGDB
AGTR1
Tclin
Family: GPCR
Novelty: 0.00033439
Score: 0.996
Data Source: Reactome,STRINGDB
AGTR2
Tchem
Family: GPCR
Novelty: 0.00064774
Score: 0.993
Data Source: Reactome,STRINGDB
ACE2
Tchem
Family: Enzyme
Novelty: 0.00028408
Score: 0.991
Data Source: Reactome,STRINGDB
CMA1
Tchem
Family: Enzyme
Novelty: 0.00091144
Score: 0.983
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1855.28

PubMed score by year
PubTator Score  12223.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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