SERPINA1
Alpha-1-antitrypsin
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.95 | ||
kinase perturbation | 0.88 | ||
cellular component | 0.86 | ||
small molecule perturbation | 0.83 | ||
gene perturbation | 0.76 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
ER to Golgi Anterograde Transport | ||||
Hemostasis | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum albumin measurement | 1 | 9 | 9 | 99.6 | |||||
sex hormone-binding globulin measurement | 6 | 3 | 13 | 98 | |||||
testosterone measurement | 6 | 4 | 10 | 97.6 | |||||
blood protein measurement | 1 | 4 | 4 | 96.7 | |||||
calcium measurement | 1 | 4 | 4 | 95.9 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum albumin measurement | 9 | 99.6 | |||||
sex hormone-binding globulin measurement | 13 | 98 | |||||
testosterone measurement | 10 | 97.6 | |||||
blood protein measurement | 4 | 96.7 | |||||
calcium measurement | 4 | 95.9 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | serpin family A member 1 | 467541 | ||||||
Macaque | serpin family A member 1 | 701361 | ||||||
Mouse | MGI:891967 | 20704 | ||||||
Mouse | MGI:891969 | 20702 | ||||||
Rat | RGD:3326 | 24648 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | serpin family A member 1 | |||||
Macaque | serpin family A member 1 | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
PMID | Year | Title |
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