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Tbio
SERPINA1
Alpha-1-antitrypsin

Protein Summary
Description
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355814
  • ENSP00000348068
  • ENSG00000197249
  • ENST00000393087
  • ENSP00000376802
  • ENST00000393088
  • ENSP00000376803
  • ENST00000402629
  • ENSP00000386094
  • ENST00000404814
  • ENSP00000385960
  • ENST00000437397
  • ENSP00000408474
  • ENST00000440909
  • ENSP00000390299
  • ENST00000448921
  • ENSP00000416066
  • ENST00000449399
  • ENSP00000416354
  • ENST00000489769
  • ENSP00000451525
  • ENST00000636712
  • ENSP00000490054

Symbol
  • AAT
  • PI
  • PI
  • A1A
  • AAT
  • PI1
  • A1AT
  • nNIF
  • PRO2275
  • alpha1AT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.88
cellular component
0.86
small molecule perturbation
0.83
gene perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7852.95   (req: < 5)
Gene RIFs: 464   (req: <= 3)
Antibodies: 1506   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7852.95   (req: >= 5)
Gene RIFs: 464   (req: > 3)
Antibodies: 1506   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0