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Tclin
SERPINC1
Antithrombin-III

Protein Summary
Description
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367698
  • ENSP00000356671
  • ENSG00000117601

Symbol
  • AT3
  • AT3
  • AT3D
  • ATIII
  • THPH7
  • ATIII-R2
  • ATIII-T1
  • ATIII-T2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
biological term
0.8
chemical
0.72
disease
0.7
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11380.59   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 764   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11380.59   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 764   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
1
1
52.5
insomnia measurement
1
1
0
1
43.3
heel bone mineral density
1
1
1
36.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
52.5
insomnia measurement
0
1
43.3
heel bone mineral density
1
36.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family C member 1
VGNC:9954
457528
Macaque
serpin family C member 1
708854
Mouse
MGI:88095
11905
Dog
serpin family C member 1
VGNC:46034
480066
Horse
serpin family C member 1
VGNC:22854
100061173
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family C member 1
Macaque
serpin family C member 1
Mouse
Dog
serpin family C member 1
Horse
serpin family C member 1
Protein Data Bank (27)
1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Metabolism of proteins
Protein-Protein Interactions (285)
1 – 10 of 285
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999194617
p_ni: 0.000805383
Score: 0.16
Data Source: BioPlex,STRINGDB
TEX15
Tbio
Novelty: 0.08059572
p_int: 0.991982236
p_ni: 0.000214932
p_wrong: 0.007802832
Score: 0.309
Data Source: BioPlex,STRINGDB
PMCH
Tbio
Novelty: 0.00600873
p_int: 0.986092257
p_ni: 0.013901804
p_wrong: 0.000005939
Data Source: BioPlex
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.969817352
p_ni: 0.030173961
p_wrong: 0.000008687
Data Source: BioPlex
BTD
Tbio
Family: Enzyme
Novelty: 0.01638573
p_int: 0.965190884
p_ni: 0.034808677
p_wrong: 4.4e-7
Score: 0.37
Data Source: BioPlex,STRINGDB
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.94329349
p_ni: 0.055312475
p_wrong: 0.001394035
Score: 0.201
Data Source: BioPlex,STRINGDB
SUCLG1
Tbio
Family: Enzyme
Novelty: 0.01113643
p_int: 0.941102237
p_ni: 0.058897763
Score: 0.518
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.81686114
p_ni: 0.18313886
Score: 0.162
Data Source: BioPlex,STRINGDB
CBWD1
Tbio
Novelty: 0.04321511
p_int: 0.805411519
p_ni: 0.19458848
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
F9
Tchem
Family: Enzyme
Novelty: 0.00032127
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  11380.59

PubMed score by year
PubTator Score  7153.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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