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Tbio
SPINK1
Serine protease inhibitor Kazal-type 1

Protein Summary
Description
Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296695
  • ENSP00000296695
  • ENSG00000164266

Symbol
  • PSTI
  • TCP
  • PCTT
  • PSTI
  • TATI
  • Spink3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological term
0.85
small molecule perturbation
0.78
disease
0.76
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1343.67   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1343.67   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep measurement
1
1
1
15.8
1
1
0
3.8
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep measurement
1
15.8
0
3.8
13.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kazal type 1
VGNC:4174
740785
Macaque
serine peptidase inhibitor, Kazal type 1
708951
Mouse
MGI:106202
20730
Rat
RGD:3749
24833
Dog
serine peptidase inhibitor, Kazal type 1
VGNC:53474
608433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kazal type 1
Macaque
serine peptidase inhibitor, Kazal type 1
Mouse
Rat
Dog
serine peptidase inhibitor, Kazal type 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00995-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (50)
1 – 10 of 50
CD59
Tbio
Novelty:  0.0008352
p_int:  0.977193187
p_ni:  0.022515311
p_wrong:  0.000291502
Data Source:  BioPlex
GRN
Tbio
Novelty:  0.00096395
p_int:  0.771812499
p_ni:  0.216009051
p_wrong:  0.01217845
Data Source:  BioPlex
PRSS1
Tclin
Family:  Enzyme
Novelty:  0.00157396
Score:  0.924
Data Source:  STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
Score:  0.901
Data Source:  STRINGDB
CTRC
Tchem
Family:  Enzyme
Novelty:  0.00457428
Score:  0.896
Data Source:  STRINGDB
PRSS58
Tdark
Family:  Enzyme
Novelty:  0.01245254
Score:  0.86
Data Source:  STRINGDB
TMPRSS15
Tchem
Family:  Enzyme
Novelty:  0.00118305
Score:  0.816
Data Source:  STRINGDB
PRSS3P2
Tdark
Family:  Enzyme
Novelty:  0.00959404
Score:  0.811
Data Source:  STRINGDB
PRSS2
Tchem
Family:  Enzyme
Novelty:  0.00959404
Score:  0.811
Data Source:  STRINGDB
PRSS3
Tchem
Family:  Enzyme
Novelty:  0.00360444
Score:  0.805
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1343.67

PubMed score by year
PubTator Score  1269.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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