OAS1
2'-5'-oligoadenylate synthase 1
Protein Summary
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. This gene is ...more
- ENST00000202917
- ENSP00000202917
- ENSG00000089127
- ENST00000445409
- ENSP00000388001
- ENST00000452357
- ENSP00000415721
- OIAS
- OIAS
- IFI-4
- OIASI
- E18/E16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
virus perturbation | 1 | ||
PubMedID | 0.98 | ||
molecular function | 0.96 | ||
kinase perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 182.67 (req: < 5)
Gene RIFs: 63 (req: <= 3)
Antibodies: 313 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 182.67 (req: >= 5)
Gene RIFs: 63 (req: > 3)
Antibodies: 313 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (228)
Nearest Tclin Targets
Pathways (15)
Reactome (7)
KEGG (6)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interferon Signaling | ||||
Reactome | Interferon alpha/beta signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interferon Signaling | ||||
Interferon alpha/beta signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (4)
Components (7)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 83.2 | |||||
alcohol drinking | 1 | 1 | 0 | 1.6 | 66.3 | ||||
alcohol consumption measurement | 1 | 1 | 0 | 1.6 | 66.3 | ||||
high density lipoprotein cholesterol measurement | 1 | 1 | 0 | 1.4 | 52.4 | ||||
COVID-19 | 1 | 1 | 0 | 1.2 | 35 | ||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 1 | 83.2 | |||||
alcohol drinking | 0 | 1.6 | 66.3 | ||||
alcohol consumption measurement | 0 | 1.6 | 66.3 | ||||
high density lipoprotein cholesterol measurement | 0 | 1.4 | 52.4 | ||||
COVID-19 | 0 | 1.2 | 35 | ||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | 2'-5'-oligoadenylate synthetase 1 | VGNC:5516 | 739129 | |||||
Macaque | 2'-5'-oligoadenylate synthetase 1 | 712265 | ||||||
Mouse | MGI:97429 | 23960 | ||||||
Rat | RGD:6497100 | 100910735 | ||||||
Dog | 2'-5'-oligoadenylate synthetase 1 | VGNC:44086 | 608778 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | 2'-5'-oligoadenylate synthetase 1 | |||||
Macaque | 2'-5'-oligoadenylate synthetase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | 2'-5'-oligoadenylate synthetase 1 | |||||
Publication Statistics
PubMed Score 182.67
PubMed score by year
PubTator Score 99.79
PubTator score by year
Related Publications
Text Mined References (108)
GeneRif Annotations (63)
Items per page:
0 of 0
PMID | Year | Title |
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