Tbio OAS1 2'-5'-oligoadenylate synthase 1

Protein Summary

Description

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P00973
• A8K4N8
• P04820
• P29080
• P29081
• P78485
• P78486
• Q16700
• Q16701
• Q1PG42
• Q3ZM01
• Q53GC5
• Q53YA4
• Q6A1Z3
• Q6IPC6
• Q6P7N9
• Q96J61
• (2-5')oligo(A) synthase 1

Gene Name

• OAS1

Ensembl ID

• ENST00000202917
• ENSP00000202917
• ENSG00000089127
• ENST00000445409
• ENSP00000388001
• ENST00000452357
• ENSP00000415721

Symbol

• OIAS
• OIAS
• IFI-4
• OIASI
• E18/E16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
virus perturbation	1
PubMedID	0.98
molecular function	0.96
kinase perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / 2'-5'-oligoadenylate Synthase 1

Protein / Nucleic Acid Binding / 2'-5'-oligoadenylate Synthase 1

Protein / Defense/immunity Protein / 2'-5'-oligoadenylate Synthase 1

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / 2'-5'-oligoadenylate Synthase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.52   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 313   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.52   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0