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Tclin
ADA
Adenosine deaminase

Protein Summary
Description
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in ea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372874
  • ENSP00000361965
  • ENSG00000196839

Symbol
  • ADA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.91
gene perturbation
0.91
disease
0.89
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1098.87   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 460   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1098.87   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 460   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
pentostatin
Rendered image for pentostatin
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adenosine deaminase measurement
1
1
0
1.1
80.2
apolipoprotein A 1 measurement
1
1
1
46.1
total cholesterol measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adenosine deaminase measurement
0
1.1
80.2
apolipoprotein A 1 measurement
1
46.1
total cholesterol measurement
1
39.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase
VGNC:6032
741760
Macaque
adenosine deaminase
717897
Mouse
MGI:87916
11486
Rat
RGD:2031
24165
Dog
adenosine deaminase
VGNC:37568
477236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase
Macaque
adenosine deaminase
Mouse
Rat
Dog
adenosine deaminase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00813-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (51)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Gene Ontology Terms (55)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (236)
1 – 10 of 236
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.999668142
p_ni:  0.000331856
p_wrong:  2e-9
Score:  0.602
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.788085563
p_ni:  0.211914437
Score:  0.249
Data Source:  BioPlex,STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.997
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.996
Data Source:  STRINGDB
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
Score:  0.971
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.962
Data Source:  STRINGDB
ADA2
Tbio
Family:  Enzyme
Novelty:  0.01077582
Score:  0.945
Data Source:  STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.935
Data Source:  STRINGDB
ADAR
Tbio
Family:  Enzyme
Novelty:  0.00135586
Score:  0.929
Data Source:  STRINGDB
NT5C1A
Tbio
Family:  Enzyme
Novelty:  0.00634411
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1098.87

PubMed score by year
PubTator Score  3142.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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