Tchem CFB Complement factor B

Protein Summary

Description

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P00751
• B0QZQ6
• O15006
• Q29944
• Q53F89
• Q5JP67
• Q5ST50
• Q96HX6
• Q9BTF5
• Q9BX92

Gene Name

• CFB

Ensembl ID

• ENST00000399981
• ENSP00000382862
• ENSG00000241253
• ENST00000417261
• ENSP00000414889
• ENSG00000239754
• ENST00000419411
• ENSP00000391902
• ENSG00000242335
• ENST00000419920
• ENSP00000411474
• ENST00000424727
• ENSP00000401719
• ENSG00000243570
• ENST00000425368
• ENSP00000416561
• ENSG00000243649
• ENST00000426239
• ENSP00000413351
• ENST00000427888
• ENSP00000411515
• ENST00000433503
• ENSP00000388352
• ENSG00000241534
• ENST00000436692
• ENSP00000389604
• ENST00000455591
• ENSP00000414341

Symbol

• BF
• BFD
• BF
• FB
• BFD
• GBG
• CFAB
• CFBD
• PBF2
• AHUS4
• FBI12
• H2-Bf
• ARMD14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.97
disease	0.95
gene perturbation	0.81
biological term	0.75

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 879.22   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 756   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 879.22   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (14)

Explore Active Ligands

1 – 10 of 14

CHEMBL3931270

CFBTchem

IC50 : 7.52

CHEMBL3945639

CFBTchem

IC50 : 7.05

CHEMBL3926271

CFBTchem

IC50 : 6.27

CHEMBL3910541

CFBTchem

IC50 : 6.34

CHEMBL3904754

CFBTchem

IC50 : 6.53

CHEMBL3949381

CFBTchem

IC50 : 6.85

CHEMBL3908792

CFBTchem

IC50 : 7.3

CHEMBL3899277

CFBTchem

IC50 : 7

CHEMBL3958120

CFBTchem

IC50 : 7.05

CHEMBL3913748

CFBTchem

IC50 : 7.22

GWAS Traits (20)

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age-related macular degeneration	EFO_0001365	ENSG00000241534	2	2	0	1.9	96
age-related macular degeneration	EFO_0001365	ENSG00000243649	2	2	0	1.9	96
chronic hepatitis B virus infection	EFO_0004239	ENSG00000241534	1	1	0	1.9	87.7
chronic hepatitis B virus infection	EFO_0004239	ENSG00000243649	1	1	0	1.9	87.7
type I diabetes mellitus	EFO_0001359	ENSG00000243649	1	1	0	3	83.1

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age-related macular degeneration	EFO_0001365	0	1.9	96
age-related macular degeneration	EFO_0001365	0	1.9	96
chronic hepatitis B virus infection	EFO_0004239	0	1.9	87.7
chronic hepatitis B virus infection	EFO_0004239	0	1.9	87.7
type I diabetes mellitus	EFO_0001359	0	3	83.1

Reset Zoom  Beta Count   Odds Ratio

Protein Structure (12 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00751-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (849)

Reactome (7)

KEGG (2)

WikiPathways (840)

Activation of C3 and C5 (R-HSA-174577)

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Find Similar Targets

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5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of C3 and C5	6 targets	R-HSA-174577
Reactome	Alternative complement activation	4 targets	R-HSA-173736
Reactome	Complement cascade	133 targets	R-HSA-166658
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Initial triggering of complement	98 targets	R-HSA-166663

Name	Explore in Pharos	Explore in Source
Activation of C3 and C5	6 targets	R-HSA-174577
Alternative complement activation	4 targets	R-HSA-173736
Complement cascade	133 targets	R-HSA-166658
Immune System	2246 targets	R-HSA-168256
Initial triggering of complement	98 targets	R-HSA-166663

Gene Ontology Terms (10)

Functions (2)

Components (5)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
complement binding	Traceable Author Statement (TAS)	UniProtKB
serine-type endopeptidase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (162)

Explore Interacting Targets

1 – 10 of 162

• See Interactions on String-DB

NPC2

Tbio

Novelty: 0.00342898

p_int: 0.998895642

p_ni: 0.000940978

p_wrong: 0.00016338

Score: 0.697

Data Source: BioPlex,STRINGDB

GDPD1

Tbio

Family: Enzyme

Novelty: 0.28722153

p_int: 0.998267911

p_ni: 0.000001275

p_wrong: 0.001730813

Score: 0.204

Data Source: BioPlex,STRINGDB

NME2

Tbio

Family: Kinase

Novelty: 0.00257937

p_int: 0.992439312

p_ni: 0.007560674

p_wrong: 1.4e-8

Data Source: BioPlex

TUBB8

Tclin

Novelty: 0.06403117

p_int: 0.991046728

p_ni: 0.008953272

Data Source: BioPlex

CST4

Tbio

Novelty: 0.00773554

p_int: 0.987200915

p_ni: 0.012788263

p_wrong: 0.000010821

Data Source: BioPlex

EPHA4

Tchem

Family: Kinase

Novelty: 0.00321698

p_int: 0.978847105

p_ni: 0.021152446

p_wrong: 4.49e-7

Data Source: BioPlex

ZG16B

Tbio

Novelty: 0.08792924

p_int: 0.97064628

p_ni: 0.029353158

p_wrong: 5.62e-7

Data Source: BioPlex

HSPA5

Tchem

Novelty: 0.00043424

p_int: 0.961247844

p_ni: 0.038752156

Data Source: BioPlex

TUBB3

Tclin

Novelty: 0.00195963

p_int: 0.915004138

p_ni: 0.084995862

Data Source: BioPlex

RSPRY1

Tdark

Novelty: 0.26883105

p_int: 0.903855508

p_ni: 0.096144491

p_wrong: 1e-9

Data Source: BioPlex

Publication Statistics

PubMed Score  879.22

PubMed score by year

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PubTator Score  350.03

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cleavage on pair of basic residues
Complement alternate pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycation
Glycoprotein

GWAS Trait Find Similar Targets

age-related macular degeneration
atrophic macular degeneration
autoimmune thyroid disease
chronic hepatitis B virus infection
coronary artery disease
neutrophil percentage of leukocytes
systemic lupus erythematosus
type I diabetes mellitus
ulcerative colitis
wet macular degeneration

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
renal/urinary system phenotype
reproductive system phenotype
skeleton phenotype