Tchem CFB Complement factor B

Protein Summary

Description

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P00751
• B0QZQ6
• O15006
• Q29944
• Q53F89
• Q5JP67
• Q5ST50
• Q96HX6
• Q9BTF5
• Q9BX92

Gene Name

• CFB

Ensembl ID

• ENST00000399981
• ENSP00000382862
• ENSG00000241253
• ENST00000417261
• ENSP00000414889
• ENSG00000239754
• ENST00000419411
• ENSP00000391902
• ENSG00000242335
• ENST00000419920
• ENSP00000411474
• ENST00000424727
• ENSP00000401719
• ENSG00000243570
• ENST00000425368
• ENSP00000416561
• ENSG00000243649
• ENST00000426239
• ENSP00000413351
• ENST00000427888
• ENSP00000411515
• ENST00000433503
• ENSP00000388352
• ENSG00000241534
• ENST00000436692
• ENSP00000389604
• ENST00000455591
• ENSP00000414341

Symbol

• BF
• BFD
• BF
• FB
• BFD
• GBG
• CFAB
• CFBD
• PBF2
• AHUS4
• FBI12
• H2-Bf
• ARMD14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.97
disease	0.95
gene perturbation	0.81
biological term	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1235.7   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 756   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1235.7   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0