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Tchem
CFB
Complement factor B

Protein Summary
Description
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while B ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399981
  • ENSP00000382862
  • ENSG00000241253
  • ENST00000417261
  • ENSP00000414889
  • ENSG00000239754
  • ENST00000419411
  • ENSP00000391902
  • ENSG00000242335
  • ENST00000419920
  • ENSP00000411474
  • ENST00000424727
  • ENSP00000401719
  • ENSG00000243570
  • ENST00000425368
  • ENSP00000416561
  • ENSG00000243649
  • ENST00000426239
  • ENSP00000413351
  • ENST00000427888
  • ENSP00000411515
  • ENST00000433503
  • ENSP00000388352
  • ENSG00000241534
  • ENST00000436692
  • ENSP00000389604
  • ENST00000455591
  • ENSP00000414341

Symbol
  • BF
  • BFD
  • BF
  • FB
  • BFD
  • GBG
  • CFAB
  • CFBD
  • PBF2
  • AHUS4
  • FBI12
  • H2-Bf
  • ARMD14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.97
disease
0.95
gene perturbation
0.81
biological term
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 879.22   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 756   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 879.22   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.9
96
2
2
0
1.9
96
chronic hepatitis B virus infection
1
1
0
1.9
87.7
chronic hepatitis B virus infection
1
1
0
1.9
87.7
1
1
0
3
83.1
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
96
0
1.9
96
chronic hepatitis B virus infection
0
1.9
87.7
chronic hepatitis B virus infection
0
1.9
87.7
0
3
83.1
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (849)
Activation of C3 and C5 (R-HSA-174577)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of C3 and C5
Reactome
Alternative complement activation
Reactome
Complement cascade
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Activation of C3 and C5
Alternative complement activation
Complement cascade
Immune System
Initial triggering of complement
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (162)
1 – 10 of 162
NPC2
Tbio
Novelty: 0.00342898
p_int: 0.998895642
p_ni: 0.000940978
p_wrong: 0.00016338
Score: 0.697
Data Source: BioPlex,STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.998267911
p_ni: 0.000001275
p_wrong: 0.001730813
Score: 0.204
Data Source: BioPlex,STRINGDB
NME2
Tbio
Family: Kinase
Novelty: 0.00257937
p_int: 0.992439312
p_ni: 0.007560674
p_wrong: 1.4e-8
Data Source: BioPlex
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.991046728
p_ni: 0.008953272
Data Source: BioPlex
CST4
Tbio
Novelty: 0.00773554
p_int: 0.987200915
p_ni: 0.012788263
p_wrong: 0.000010821
Data Source: BioPlex
EPHA4
Tchem
Family: Kinase
Novelty: 0.00321698
p_int: 0.978847105
p_ni: 0.021152446
p_wrong: 4.49e-7
Data Source: BioPlex
ZG16B
Tbio
Novelty: 0.08792924
p_int: 0.97064628
p_ni: 0.029353158
p_wrong: 5.62e-7
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.961247844
p_ni: 0.038752156
Data Source: BioPlex
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.915004138
p_ni: 0.084995862
Data Source: BioPlex
RSPRY1
Tdark
Novelty: 0.26883105
p_int: 0.903855508
p_ni: 0.096144491
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  879.22

PubMed score by year
PubTator Score  350.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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