Protein Summary
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while B ...more
- ENST00000399981
- ENSP00000382862
- ENSG00000241253
- ENST00000417261
- ENSP00000414889
- ENSG00000239754
- ENST00000419411
- ENSP00000391902
- ENSG00000242335
- ENST00000419920
- ENSP00000411474
- ENST00000424727
- ENSP00000401719
- ENSG00000243570
- ENST00000425368
- ENSP00000416561
- ENSG00000243649
- ENST00000426239
- ENSP00000413351
- ENST00000427888
- ENSP00000411515
- ENST00000433503
- ENSP00000388352
- ENSG00000241534
- ENST00000436692
- ENSP00000389604
- ENST00000455591
- ENSP00000414341
- BF
- BFD
- BF
- FB
- BFD
- GBG
- CFAB
- CFBD
- PBF2
- AHUS4
- FBI12
- H2-Bf
- ARMD14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
protein domain | 0.97 | ||
disease | 0.95 | ||
gene perturbation | 0.81 | ||
biological term | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 906.02 (req: < 5)
Gene RIFs: 89 (req: <= 3)
Antibodies: 756 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 906.02 (req: >= 5)
Gene RIFs: 89 (req: > 3)
Antibodies: 756 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 26
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (26)
Protein-Protein Interactions (162)
NPC2
Novelty: 0.00342898
p_int: 0.998895642
p_ni: 0.000940978
p_wrong: 0.00016338
Score: 0.697
Data Source: BioPlex,STRINGDB
GDPD1
Family: Enzyme
Novelty: 0.28722153
p_int: 0.998267911
p_ni: 0.000001275
p_wrong: 0.001730813
Score: 0.204
Data Source: BioPlex,STRINGDB
NME2
Family: Kinase
Novelty: 0.00257937
p_int: 0.992439312
p_ni: 0.007560674
p_wrong: 1.4e-8
Data Source: BioPlex
CST4
Novelty: 0.00773554
p_int: 0.987200915
p_ni: 0.012788263
p_wrong: 0.000010821
Data Source: BioPlex
EPHA4
Family: Kinase
Novelty: 0.00321698
p_int: 0.978847105
p_ni: 0.021152446
p_wrong: 4.49e-7
Data Source: BioPlex
ZG16B
Novelty: 0.08792924
p_int: 0.97064628
p_ni: 0.029353158
p_wrong: 5.62e-7
Data Source: BioPlex
RSPRY1
Novelty: 0.26883105
p_int: 0.903855508
p_ni: 0.096144491
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (849)
Reactome (7)
KEGG (2)
WikiPathways (840)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of C3 and C5 | ||||
Reactome | Alternative complement activation | ||||
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of C3 and C5 | ||||
Alternative complement activation | ||||
Complement cascade | ||||
Immune System | ||||
Initial triggering of complement | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (152)
Items per page:
1 – 5 of 152
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
9 | 9 | 0 | 1.9 | 99.3 | ||||||
9 | 9 | 0 | 1.9 | 99.3 | ||||||
6 | 6 | 0 | 2.3 | 99.2 | ||||||
6 | 6 | 0 | 2.3 | 99.2 | ||||||
3 | 5 | 0 | 1.8 | 98.7 | ||||||
Items per page:
1 – 5 of 152
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.9 | 99.3 | |||||
0 | 1.9 | 99.3 | |||||
0 | 2.3 | 99.2 | |||||
0 | 2.3 | 99.2 | |||||
0 | 1.8 | 98.7 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 906.02
PubMed score by year
PubTator Score 350.03
PubTator score by year
Related Publications
Text Mined References (170)
GeneRif Annotations (89)
Items per page:
0 of 0
PMID | Year | Title |
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