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Tclin
PLAT
Tissue-type plasminogen activator

Protein Summary
Description
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in mult ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220809
  • ENSP00000220809
  • ENSG00000104368
  • ENST00000352041
  • ENSP00000270188
  • ENST00000429089
  • ENSP00000392045

Symbol
  • TPA
  • T-PA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
biological term
0.99
disease
0.97
small molecule perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6176.37   (req: < 5)
Gene RIFs: 234   (req: <= 3)
Antibodies: 725   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6176.37   (req: >= 5)
Gene RIFs: 234   (req: > 3)
Antibodies: 725   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 86
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
aminocaproic acid
Rendered image for aminocaproic acid
Active Ligands (86)
1 – 10 of 86
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue plasminogen activator measurement
1
1
1
21.5
1
1
0
1.9
17.8
hair color
1
1
0
1.1
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue plasminogen activator measurement
1
21.5
0
1.9
17.8
hair color
0
1.1
7.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plasminogen activator, tissue type
VGNC:3003
472748
Macaque
plasminogen activator, tissue type
704475
Mouse
MGI:97610
18791
Rat
RGD:3342
25692
Dog
plasminogen activator, tissue type
482840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plasminogen activator, tissue type
Macaque
plasminogen activator, tissue type
Mouse
Rat
Dog
plasminogen activator, tissue type
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00750-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Dissolution of Fibrin Clot (R-HSA-75205)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Reactome
Signal Transduction
Reactome
Signaling by PDGF
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Dissolution of Fibrin Clot
Hemostasis
Signal Transduction
Signaling by PDGF
Signaling by Receptor Tyrosine Kinases
Protein-Protein Interactions (132)
1 – 10 of 132
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.999991505
p_ni:  0.000008495
Score:  0.963
Data Source:  BioPlex,STRINGDB
SERPINF2
Tbio
Novelty:  0.00054719
p_int:  0.999942222
p_ni:  0.000057778
Score:  0.984
Data Source:  BioPlex,STRINGDB
CCL3L1
Tbio
Novelty:  0.01124082
p_int:  0.998736274
p_ni:  0.001263726
Score:  0.224
Data Source:  BioPlex,STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
p_int:  0.99574881
p_ni:  0.00425119
Score:  0.605
Data Source:  BioPlex,STRINGDB
SERPINA10
Tbio
Family:  Enzyme
Novelty:  0.01229147
p_int:  0.994794209
p_ni:  0.005205791
Score:  0.373
Data Source:  BioPlex,STRINGDB
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.977650264
p_ni:  0.0223497
p_wrong:  3.7e-8
Data Source:  BioPlex
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.862954114
p_ni:  0.137045835
p_wrong:  5.2e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.848943307
p_ni:  0.151056439
p_wrong:  2.54e-7
Data Source:  BioPlex
SERPINB6
Tbio
Novelty:  0.00568825
p_int:  0.838717049
p_ni:  0.161279445
p_wrong:  0.000003507
Score:  0.436
Data Source:  BioPlex,STRINGDB
SERPINE2
Tbio
Novelty:  0.00246375
p_int:  0.835763985
p_ni:  0.164233778
p_wrong:  0.000002238
Score:  0.979
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6176.37

PubMed score by year
PubTator Score  4327.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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