Tclin PLAT Tissue-type plasminogen activator

Protein Summary

Description

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P00750
• A8K022
• B2R8E8
• Q15103
• Q503B0
• Q6PJA5
• Q7Z7N2
• Q86YK8
• Q9BU99
• Q9BZW1
• t-PA

Gene Name

• PLAT

Ensembl ID

• ENST00000220809
• ENSP00000220809
• ENSG00000104368
• ENST00000352041
• ENSP00000270188
• ENST00000429089
• ENSP00000392045

Symbol

• TPA
• T-PA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
protein domain	1
biological term	0.99
disease	0.97
small molecule perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Tissue-type Plasminogen Activator

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Tissue-type Plasminogen Activator

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8999.55   (req: < 5)

Gene RIFs: 252   (req: <= 3)

Antibodies: 725   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8999.55   (req: >= 5)

Gene RIFs: 252   (req: > 3)

Antibodies: 725   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 86

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1