Tchem PLAU Urokinase-type plasminogen activator

Protein Summary

Description

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P00749
• B4DPZ2
• Q15844
• Q16618
• Q53XS3
• Q5SWW9
• Q969W6
• U-plasminogen activator

Gene Name

• PLAU

Ensembl ID

• ENST00000372764
• ENSP00000361850
• ENSG00000122861
• ENST00000496777
• ENSP00000431795

Symbol

• ATF
• QPD
• UPA
• URK
• u-PA
• BDPLT5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
protein domain	0.99
drug	0.97
virus perturbation	0.97
small molecule perturbation	0.89

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Urokinase-type Plasminogen Activator

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Urokinase-type Plasminogen Activator

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2217.75   (req: < 5)

Gene RIFs: 445   (req: <= 3)

Antibodies: 966   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2217.75   (req: >= 5)

Gene RIFs: 445   (req: > 3)

Antibodies: 966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 490

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1