PLAU
Urokinase-type plasminogen activator
Protein Summary
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
- ENST00000372764
- ENSP00000361850
- ENSG00000122861
- ENST00000496777
- ENSP00000431795
- ATF
- QPD
- UPA
- URK
- u-PA
- BDPLT5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
protein domain | 0.99 | ||
drug | 0.97 | ||
virus perturbation | 0.97 | ||
small molecule perturbation | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2095.77 (req: < 5)
Gene RIFs: 418 (req: <= 3)
Antibodies: 966 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2095.77 (req: >= 5)
Gene RIFs: 418 (req: > 3)
Antibodies: 966 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 490
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (490)
Protein-Protein Interactions (277)
SERPINE2
Novelty: 0.00246375
p_int: 0.999940035
p_ni: 0.000059965
Score: 0.986
Data Source: BioPlex,STRINGDB
MOCOS
Family: Enzyme
Novelty: 0.05022905
p_int: 0.976869943
p_ni: 0.02312786
p_wrong: 0.000002197
Score: 0.378
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (8)
Upstream (7)
Downstream (1)
1 – 5 of 7
Pathways (39)
Reactome (5)
KEGG (6)
PathwayCommons (16)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Dissolution of Fibrin Clot | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Dissolution of Fibrin Clot | ||||
Hemostasis | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (1)
Components (8)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urokinase plasminogen activator surface receptor measurement | 1 | 1 | 1 | 82.3 | |||||
forced expiratory volume | 1 | 2 | 2 | 76.4 | |||||
FEV/FEC ratio | 1 | 2 | 2 | 63.6 | |||||
1 | 1 | 0 | 1.1 | 61.4 | |||||
1 | 1 | 0 | 1.1 | 56.8 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urokinase plasminogen activator surface receptor measurement | 1 | 82.3 | |||||
forced expiratory volume | 2 | 76.4 | |||||
FEV/FEC ratio | 2 | 63.6 | |||||
0 | 1.1 | 61.4 | |||||
0 | 1.1 | 56.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | plasminogen activator, urokinase | 738078 | ||||||
Macaque | plasminogen activator, urokinase | 705853 | ||||||
Mouse | MGI:97611 | 18792 | ||||||
Rat | RGD:3343 | 25619 | ||||||
Dog | plasminogen activator, urokinase | VGNC:52017 | 403426 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | plasminogen activator, urokinase | |||||
Macaque | plasminogen activator, urokinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | plasminogen activator, urokinase | |||||
Publication Statistics
PubMed Score 2095.77
PubMed score by year
PubTator Score 3198.71
PubTator score by year
Related Publications
Text Mined References (523)
GeneRif Annotations (418)
Items per page:
0 of 0
PMID | Year | Title |
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