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Tchem
PLAU
Urokinase-type plasminogen activator

Protein Summary
Description
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372764
  • ENSP00000361850
  • ENSG00000122861
  • ENST00000496777
  • ENSP00000431795

Symbol
  • ATF
  • QPD
  • UPA
  • URK
  • u-PA
  • BDPLT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.99
drug
0.97
virus perturbation
0.97
small molecule perturbation
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2079.09   (req: < 5)
Gene RIFs: 418   (req: <= 3)
Antibodies: 966   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2079.09   (req: >= 5)
Gene RIFs: 418   (req: > 3)
Antibodies: 966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 470
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
gabexate
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
64.9
1
1
0
1.1
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
64.9
0
1.1
30
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plasminogen activator, urokinase
738078
Macaque
plasminogen activator, urokinase
705853
Mouse
MGI:97611
18792
Rat
RGD:3343
25619
Dog
plasminogen activator, urokinase
VGNC:52017
403426
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plasminogen activator, urokinase
Macaque
plasminogen activator, urokinase
Mouse
Rat
Dog
plasminogen activator, urokinase
Protein Structure (128 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00749-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 128
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Dissolution of Fibrin Clot (R-HSA-75205)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Dissolution of Fibrin Clot
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (25)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (277)
1 – 10 of 277
SERPINE2
Tbio
Novelty: 0.00246375
p_int: 0.999940035
p_ni: 0.000059965
Score: 0.986
Data Source: BioPlex,STRINGDB
MOCOS
Tbio
Family: Enzyme
Novelty: 0.05022905
p_int: 0.976869943
p_ni: 0.02312786
p_wrong: 0.000002197
Score: 0.378
Data Source: BioPlex,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.999
Data Source: Reactome,STRINGDB
SERPINE1
Tchem
Novelty: 0.00017629
Score: 0.999
Data Source: Reactome,STRINGDB
SERPINB2
Tbio
Novelty: 0.00204345
Score: 0.988
Data Source: Reactome,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
Score: 0.965
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.96
Data Source: STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.952
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.951
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.951
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  2079.09

PubMed score by year
PubTator Score  3198.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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