Tchem PLAU Urokinase-type plasminogen activator

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Urokinase-type Plasminogen Activator

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Urokinase-type Plasminogen Activator

Protein Summary

Description

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P00749
• B4DPZ2
• Q15844
• Q16618
• Q53XS3
• Q5SWW9
• Q969W6
• U-plasminogen activator

Gene Name

• PLAU

Ensembl ID

• ENST00000372764
• ENSP00000361850
• ENSG00000122861
• ENST00000496777
• ENSP00000431795

Symbol

• ATF
• QPD
• UPA
• URK
• u-PA
• BDPLT5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
protein domain	0.99
drug	0.97
virus perturbation	0.97
small molecule perturbation	0.89

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2079.09   (req: < 5)

Gene RIFs: 418   (req: <= 3)

Antibodies: 966   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2079.09   (req: >= 5)

Gene RIFs: 418   (req: > 3)

Antibodies: 966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 470

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

gabexate

PLAUTchem Enzyme

IC50 : 6.37

Active Ligands (470)

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1 – 10 of 470

CHEMBL96433

PLAUTchem Enzyme

Ki : 8.1

CHEMBL330234

PLAUTchem Enzyme

Ki : 7

CHEMBL48608

PLAUTchem Enzyme

Ki : 7.26

CHEMBL328772

PLAUTchem Enzyme

Ki : 7.46

CHEMBL92883

PLAUTchem Enzyme

Ki : 7.26

CHEMBL94775

PLAUTchem Enzyme

Ki : 7.6

CHEMBL319047

PLAUTchem Enzyme

Ki : 7.04

CHEMBL104505

PLAUTchem Enzyme

Ki : 8.7

CHEMBL105395

PLAUTchem Enzyme

Ki : 7

CHEMBL104166

PLAUTchem Enzyme

Ki : 9.21

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	1	1	0	1.1	64.9
inflammatory bowel disease	EFO_0003767	1	1	0	1.1	30

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	0	1.1	64.9
inflammatory bowel disease	EFO_0003767	0	1.1	30

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	plasminogen activator, urokinase		738078
Macaque	plasminogen activator, urokinase		705853
Mouse	plasminogen activator, urokinase	MGI:97611	18792
Rat	plasminogen activator, urokinase	RGD:3343	25619
Dog	plasminogen activator, urokinase	VGNC:52017	403426

Species	Name	OMA	EggNOG	Inparanoid
Chimp	plasminogen activator, urokinase
Macaque	plasminogen activator, urokinase
Mouse	plasminogen activator, urokinase
Rat	plasminogen activator, urokinase
Dog	plasminogen activator, urokinase

Protein Structure (128 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00749-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 128

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (39)

Reactome (5)

KEGG (6)

PathwayCommons (16)

WikiPathways (12)

Dissolution of Fibrin Clot (R-HSA-75205)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (25)

Functions (1)

Components (8)

Processes (16)

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10

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GO Term	Evidence	Assigned by
serine-type endopeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (277)

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1 – 10 of 277

• See Interactions on String-DB

SERPINE2

Tbio

Novelty: 0.00246375

p_int: 0.999940035

p_ni: 0.000059965

Score: 0.986

Data Source: BioPlex,STRINGDB

MOCOS

Tbio

Family: Enzyme

Novelty: 0.05022905

p_int: 0.976869943

p_ni: 0.02312786

p_wrong: 0.000002197

Score: 0.378

Data Source: BioPlex,STRINGDB

PLAUR

Tchem

Family: Enzyme

Novelty: 0.00087642

Score: 0.999

Data Source: Reactome,STRINGDB

SERPINE1

Tchem

Novelty: 0.00017629

Score: 0.999

Data Source: Reactome,STRINGDB

SERPINB2

Tbio

Novelty: 0.00204345

Score: 0.988

Data Source: Reactome,STRINGDB

VTN

Tbio

Family: TF

Novelty: 0.00046861

Score: 0.965

Data Source: STRINGDB

FN1

Tchem

Novelty: 0.00003647

Score: 0.96

Data Source: STRINGDB

F2

Tclin

Family: Enzyme

Novelty: 0.00004833

Score: 0.952

Data Source: STRINGDB

EGFR

Tclin

Family: Kinase

Novelty: 0.00007274

Score: 0.951

Data Source: STRINGDB

PLG

Tclin

Family: Enzyme

Novelty: 0.00004806

Score: 0.951

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  2079.09

PubMed score by year

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PubTator Score  3198.71

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Blood coagulation
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Fibrinolysis
Glycoprotein
Hemostasis

GWAS Trait Find Similar Targets

Crohn's disease
inflammatory bowel disease

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype