Protein Classes
Protein Summary
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallik ...more
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IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 674.4 (req: < 5)
Gene RIFs: 129 (req: <= 3)
Antibodies: 656 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 674.4 (req: >= 5)
Gene RIFs: 129 (req: > 3)
Antibodies: 656 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (8)
1 – 8 of 8
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
partial thromboplastin time | 1 | 1 | 1 | 75.5 | |||||
interleukin 16 measurement | 1 | 1 | 1 | 42.2 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
partial thromboplastin time | 1 | 75.5 | |||||
interleukin 16 measurement | 1 | 42.2 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor XII | VGNC:6868 | 462304 | |||||
Macaque | coagulation factor XII | 699875 | ||||||
Mouse | MGI:1891012 | 58992 | ||||||
Rat | RGD:1359175 | 306761 | ||||||
Horse | coagulation factor XII | VGNC:17754 | 100068589 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor XII | |||||
Macaque | coagulation factor XII | |||||
Mouse | ||||||
Rat | ||||||
Horse | coagulation factor XII | |||||
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (8)
Reactome (3)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Reactome | Intrinsic Pathway of Fibrin Clot Formation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Intrinsic Pathway of Fibrin Clot Formation | ||||
Gene Ontology Terms (21)
Functions (3)
Components (5)
Processes (13)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (105)
1 – 10 of 105
ANKRD40
Novelty: 1.06633958
p_int: 0.862601606
p_ni: 0.137398394
Score: 0.209
Data Source: BioPlex,STRINGDB
HSPA8
Novelty: 0.00081014
p_int: 0.797326936
p_ni: 0.202673064
Score: 0.176
Data Source: BioPlex,STRINGDB
KNG1
Novelty: 0.00007684
Score: 0.985
Data Source: Reactome,STRINGDB
KLKB1
Family: Enzyme
Novelty: 0.00109438
Score: 0.974
Data Source: Reactome,STRINGDB
SERPING1
Family: Enzyme
Novelty: 0.00068448
Score: 0.974
Data Source: Reactome,STRINGDB
F9
Family: Enzyme
Novelty: 0.00032127
Score: 0.961
Data Source: STRINGDB
F11
Family: Enzyme
Novelty: 0.00169618
Score: 0.959
Data Source: Reactome,STRINGDB
SERPINC1
Novelty: 0.00008721
Score: 0.958
Data Source: STRINGDB
GP1BA
Novelty: 0.00138736
Score: 0.957
Data Source: Reactome,STRINGDB
C1QBP
Novelty: 0.00532825
Score: 0.928
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 674.40
PubMed score by year
PubTator Score 919.39
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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