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Tchem
F12
Coagulation factor XII

Protein Summary
Description
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallik ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253496
  • ENSP00000253496
  • ENSG00000131187

Symbol
  • HAF
  • HAE3
  • HAEX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.97
biological term
0.8
disease
0.69
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.47   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 656   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.47   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
8
11
15.2
99.3
creatinine measurement
5
6
7
97
partial thromboplastin time
2
2
2
96.1
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
15.2
99.3
creatinine measurement
7
97
partial thromboplastin time
2
96.1
hematocrit
5
96.1
hemoglobin measurement
4
94.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XII
VGNC:6868
462304
Macaque
coagulation factor XII
699875
Mouse
MGI:1891012
58992
Rat
RGD:1359175
306761
Horse
coagulation factor XII
VGNC:17754
100068589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XII
Macaque
coagulation factor XII
Mouse
Rat
Horse
coagulation factor XII
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00748-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Protein-Protein Interactions (105)
1 – 10 of 105
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.862601606
p_ni:  0.137398394
Score:  0.209
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.797326936
p_ni:  0.202673064
Score:  0.176
Data Source:  BioPlex,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.985
Data Source:  Reactome,STRINGDB
KLKB1
Tclin
Family:  Enzyme
Novelty:  0.00109438
Score:  0.974
Data Source:  Reactome,STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Score:  0.974
Data Source:  Reactome,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
Score:  0.961
Data Source:  STRINGDB
F11
Tchem
Family:  Enzyme
Novelty:  0.00169618
Score:  0.959
Data Source:  Reactome,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.958
Data Source:  STRINGDB
GP1BA
Tbio
Novelty:  0.00138736
Score:  0.957
Data Source:  Reactome,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
Score:  0.928
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  684.47

PubMed score by year
PubTator Score  919.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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