Protein Summary
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallik ...more
- ENST00000253496
- ENSP00000253496
- ENSG00000131187
- HAF
- HAE3
- HAEX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.97 | ||
biological term | 0.8 | ||
disease | 0.69 | ||
biological process | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 684.47 (req: < 5)
Gene RIFs: 129 (req: <= 3)
Antibodies: 656 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 684.47 (req: >= 5)
Gene RIFs: 129 (req: > 3)
Antibodies: 656 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 85
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (85)
Protein-Protein Interactions (105)
ANKRD40
Novelty: 1.06633958
p_int: 0.862601606
p_ni: 0.137398394
Score: 0.209
Data Source: BioPlex,STRINGDB
HSPA8
Novelty: 0.00081014
p_int: 0.797326936
p_ni: 0.202673064
Score: 0.176
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (8)
Reactome (3)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Reactome | Intrinsic Pathway of Fibrin Clot Formation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Intrinsic Pathway of Fibrin Clot Formation | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (5)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (57)
Items per page:
1 – 5 of 57
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 9 | 8 | 11 | 15.2 | 99.3 | ||||
creatinine measurement | 5 | 6 | 7 | 97 | |||||
partial thromboplastin time | 2 | 2 | 2 | 96.1 | |||||
hematocrit | 5 | 5 | 5 | 96.1 | |||||
hemoglobin measurement | 4 | 4 | 4 | 94.3 | |||||
Items per page:
1 – 5 of 57
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 11 | 15.2 | 99.3 | ||||
creatinine measurement | 7 | 97 | |||||
partial thromboplastin time | 2 | 96.1 | |||||
hematocrit | 5 | 96.1 | |||||
hemoglobin measurement | 4 | 94.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor XII | VGNC:6868 | 462304 | |||||
Macaque | coagulation factor XII | 699875 | ||||||
Mouse | MGI:1891012 | 58992 | ||||||
Rat | RGD:1359175 | 306761 | ||||||
Horse | coagulation factor XII | VGNC:17754 | 100068589 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor XII | |||||
Macaque | coagulation factor XII | |||||
Mouse | ||||||
Rat | ||||||
Horse | coagulation factor XII | |||||
Publication Statistics
PubMed Score 684.47
PubMed score by year
PubTator Score 919.39
PubTator score by year
Related Publications
Text Mined References (191)
GeneRif Annotations (129)
Items per page:
0 of 0
PMID | Year | Title |
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