Tclin PLG Plasminogen

Protein Summary

Description

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• P00747
• Q15146
• Q5TEH4
• Q6PA00

Gene Name

• PLG

Ensembl ID

• ENST00000308192
• ENSP00000308938
• ENSG00000122194

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
gene perturbation	0.97
biological process	0.82
disease perturbation	0.79
cellular component	0.74

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Plasminogen

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Plasminogen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20832.25   (req: < 5)

Gene RIFs: 244   (req: <= 3)

Antibodies: 1218   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20832.25   (req: >= 5)

Gene RIFs: 244   (req: > 3)

Antibodies: 1218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 324

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8