Tchem CFD Complement factor D

Protein Summary

Description

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P00746
• B4DV76
• Q5U5S1
• Q86VJ5
• Q8N4E0
• Q8WZB4

Gene Name

• CFD

Ensembl ID

• ENST00000327726
• ENSP00000332139
• ENSG00000197766
• ENST00000617994
• ENSP00000478745
• ENSG00000274619

Symbol

• DF
• PFD
• DF
• ADN
• PFD
• ADIPSIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.9
disease	0.79
disease perturbation	0.62
tissue sample	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Complement Factor D

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Complement Factor D

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.77   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 420   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.77   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 903

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0