Tclin F10 Coagulation factor X

Protein Summary

Description

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P00742
• Q14340

Gene Name

• F10

Ensembl ID

• ENST00000375559
• ENSP00000364709
• ENSG00000126218

Symbol

• FX
• FXA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological term	0.99
drug	0.99
kinase perturbation	0.93
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Coagulation Factor X

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Coagulation Factor X

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1974.42   (req: < 5)

Gene RIFs: 247   (req: <= 3)

Antibodies: 593   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1974.42   (req: >= 5)

Gene RIFs: 247   (req: > 3)

Antibodies: 593   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4040

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5