Tbio HPR Haptoglobin-related protein

Protein Summary

Description

Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron. This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P00739
• Q7LE20
• Q92658
• Q92659
• Q9ULB0

Gene Name

• HPR

Ensembl ID

• ENST00000540303
• ENSP00000441828
• ENSG00000261701

Symbol

• HP
• A-259H10.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.75
protein domain	0.73
disease	0.54
tissue sample	0.52
gene perturbation	0.5

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Haptoglobin-related Protein

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Haptoglobin-related Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.29   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.29   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0