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Tbio
HPR
Haptoglobin-related protein

Protein Summary
Description
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron. This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000540303
  • ENSP00000441828
  • ENSG00000261701

Symbol
  • HP
  • A-259H10.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
protein domain
0.73
disease
0.54
tissue sample
0.52
gene perturbation
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.41   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.41   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
2
7
99.4
haptoglobin measurement
1
1
1
97
total cholesterol measurement
5
2
5
4.1
95.1
triglyceride measurement
2
2
2
76
apolipoprotein B measurement
1
1
1
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
99.4
haptoglobin measurement
1
97
total cholesterol measurement
5
4.1
95.1
triglyceride measurement
2
76
apolipoprotein B measurement
1
70
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P00739-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging of heme from plasma
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging of heme from plasma
Vesicle-mediated transport
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (71)
1 – 10 of 71
HP
Tbio
Novelty: 0.00016649
Score: 0.943
Data Source: STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.921
Data Source: STRINGDB
APOL1
Tbio
Novelty: 0.00176872
Score: 0.919
Data Source: STRINGDB
APOA2
Tbio
Novelty: 0.00117627
Score: 0.865
Data Source: STRINGDB
HBA1
Tclin
Novelty: 0.00094113
Score: 0.856
Data Source: STRINGDB
PON1
Tbio
Family: Enzyme
Novelty: 0.00033137
Score: 0.853
Data Source: STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.852
Data Source: STRINGDB
APOC3
Tclin
Novelty: 0.0009635
Score: 0.837
Data Source: STRINGDB
PLTP
Tbio
Novelty: 0.00267612
Score: 0.821
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.808
Data Source: STRINGDB
Publication Statistics
PubMed Score  309.41

PubMed score by year
PubTator Score  301.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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