Tclin C1R Complement C1r subcomponent

Protein Summary

Description

C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. This gene encodes a member of the peptidase S1 protein family. The encoded protein is a proteolytic subunit in the complement system C1 complex. The complement system acts as a mediator in the innate immune response by ultimately triggering phagocytosis, inflammation, and rupturing the bacterial cell wall. Mutations in this gene are associated with Ehlers-Danlos Syndrome. [provided by RefSeq, Dec 2018]

Uniprot Accession IDs

• P00736
• A6NJQ8
• Q68D77
• Q8J012

Gene Name

• C1R

Ensembl ID

• ENST00000542285
• ENSP00000438615
• ENSG00000159403

Symbol

• EDSPD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	1
drug	0.79
gene perturbation	0.79
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Complement C1r Subcomponent

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Complement C1r Subcomponent

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.18   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 323   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.18   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1