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Tclin
F2
Prothrombin

Protein Summary
Description
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
drug
1
protein domain
1
biological process
0.99
chemical
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19563.14   (req: < 5)
Gene RIFs: 705   (req: <= 3)
Antibodies: 1010   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19563.14   (req: >= 5)
Gene RIFs: 705   (req: > 3)
Antibodies: 1010   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2748
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
5
2
1
1.9
99.1
high density lipoprotein cholesterol measurement
2
2
3
92.8
intraocular pressure measurement
1
1
1
34.4
prothrombin time measurement
1
1
1
25.9
lymphocyte count
1
1
1
20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1.9
99.1
high density lipoprotein cholesterol measurement
3
92.8
intraocular pressure measurement
1
34.4
prothrombin time measurement
1
25.9
lymphocyte count
1
20
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II, thrombin
VGNC:7501
451158
Macaque
coagulation factor II, thrombin
712729
Mouse
MGI:88380
14061
Rat
RGD:61996
29251
Dog
coagulation factor II, thrombin
VGNC:40547
100856539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II, thrombin
Macaque
coagulation factor II, thrombin
Mouse
Rat
Dog
coagulation factor II, thrombin
Protein Structure (391 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00734-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 391
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (58)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Complement cascade
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Class A/1 (Rhodopsin-like receptors)
Common Pathway of Fibrin Clot Formation
Complement cascade
Formation of Fibrin Clot (Clotting Cascade)
Gene Ontology Terms (51)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (515)
1 – 10 of 515
FGA
Tbio
Novelty: 0.00107227
Score: 0.999
Data Source: Reactome,STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.999
Data Source: Reactome,STRINGDB
FGG
Tbio
Novelty: 0.00404457
Score: 0.998
Data Source: Reactome,STRINGDB
SERPIND1
Tbio
Novelty: 0.00120897
Score: 0.998
Data Source: Reactome,STRINGDB
THBD
Tbio
Novelty: 0.00039359
Score: 0.998
Data Source: Reactome,STRINGDB
F2R
Tclin
Family: GPCR
Novelty: 0.00080964
Score: 0.998
Data Source: Reactome,STRINGDB
F5
Tbio
Novelty: 0.00161772
Score: 0.998
Data Source: Reactome,STRINGDB
FGB
Tbio
Novelty: 0.00437751
Score: 0.997
Data Source: Reactome,STRINGDB
PROC
Tchem
Family: Enzyme
Novelty: 0.00440723
Score: 0.996
Data Source: Reactome,STRINGDB
SERPINA5
Tbio
Family: Enzyme
Novelty: 0.00152504
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  19563.14

PubMed score by year
PubTator Score  18265.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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