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Tbio
LALBA
Alpha-lactalbumin

Protein Summary
Description
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301046
  • ENSP00000301046
  • ENSG00000167531

Symbol
  • LYZL7
  • LYZG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
tissue
0.63
cell line
0.58
protein domain
0.58
gene perturbation
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2687.93   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2687.93   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
57.7
myeloid white cell count
1
1
1
47.7
heel bone mineral density
1
1
1
21.2
lymphocyte count
1
1
1
12.8
sex hormone-binding globulin measurement
2
1
2
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
57.7
myeloid white cell count
1
47.7
heel bone mineral density
1
21.2
lymphocyte count
1
12.8
sex hormone-binding globulin measurement
2
8.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactalbumin alpha
VGNC:8444
743291
Macaque
lactalbumin alpha
707442
Mouse
MGI:96742
16770
Rat
RGD:2987
24528
Dog
lactalbumin alpha
VGNC:42563
403730
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactalbumin alpha
Macaque
lactalbumin alpha
Mouse
Rat
Dog
lactalbumin alpha
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00709-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Lactose synthesis (R-HSA-5653890)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lactose synthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Lactose synthesis
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (56)
1 – 10 of 56
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.994
Data Source:  Reactome,STRINGDB
LCT
Tbio
Family:  Enzyme
Novelty:  0.0019382
Score:  0.93
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.916
Data Source:  STRINGDB
GALE
Tchem
Family:  Enzyme
Novelty:  0.00256798
Score:  0.915
Data Source:  STRINGDB
CSN2
Tbio
Family:  Enzyme
Novelty:  0.00050291
Score:  0.907
Data Source:  STRINGDB
GALT
Tbio
Family:  Enzyme
Novelty:  0.0120291
Score:  0.9
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.891
Data Source:  STRINGDB
B4GALT2
Tbio
Family:  Enzyme
Novelty:  0.03492512
Score:  0.89
Data Source:  STRINGDB
CSN3
Tbio
Family:  Enzyme
Novelty:  0.00059158
Score:  0.862
Data Source:  STRINGDB
CSN1S1
Tbio
Family:  Enzyme
Novelty:  0.00200522
Score:  0.846
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2687.93

PubMed score by year
PubTator Score  934.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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